Serum Total Bilirubin Level and Prevalent Lower-Extremity Peripheral Arterial Disease

We evaluated the relationship between serum bilirubin levels and ankle-brachial index (ABI) to determine whether gender affected the relationship between bilirubin levels and peripheral arterial disease (PAD) in patients with hypertension. A total of 543 patients were included in our studies (78 patients with PAD and 465 without PAD). Peripheral arterial disease was defined as ABI <0.90 for either and/or both sides. Serum bilirubin levels were measured with a vanadate oxidation method by using fasting venous blood samples. Serum total bilirubin (TBiL) and direct bilirubin (DBiL) levels were higher in males compared with females (both P < .05). Total bilirubin and DBiL were significantly lower in the PAD group. After adjustment for cardiovascular risk factors, PAD was independently negatively related to TBiL and DBiL, with odds ratios (OR) 0.914 (95% confidence interval [CI]: 0.845-0.990) and 0.748 (95% CI: 0.572-0.977). In addition, there was a relationship between PAD and bilirubin levels (TBiL—OR = 0.884, 95% CI: 0.792-0.985; DBiL—OR = 0.621; 95% CI: 0.424-0.909) only in males but not in females. Future studies should further evaluate whether interventions that increase serum bilirubin levels will have a particular role in PAD prevention in males.

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U-shaped association between serum bilirubin levels and peripheral arterial disease in Chinese males with hypertension

10.21203/rs.3.rs-40589/v2 ◽

2020 ◽

Author(s):

Yumeng Shi ◽

Lihua Hu ◽

Minghui Li ◽

Xiao Huang ◽

Congcong Ding ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Inflection Point ◽

Total Bilirubin ◽

Arterial Disease ◽

Cross Sectional Study ◽

Serum Total Bilirubin ◽

Cross Sectional ◽

Artery Disease ◽

Peripheral Arterial ◽

The Right

Abstract Background: Previous studies have indicated that serum total bilirubin might play an important role in peripheral artery disease (PAD). However, the effects of different levels of serum total bilirubin (TBiL) on PAD development remain uncertain, and there are limited data in male participants. We aimed to examine the prevalence of PAD and TBiL among Chinese male adults with hypertension.Methods: A total of 5129 hypertensive male subjects aged 27-93 years were included in the current study. The outcome was peripheral arterial disease (PAD), defined as present when the ABI of either side was ≤ 0.90.Results: Of 5129 hypertensive male participants, 194 (3.78%) had PAD, and the mean serum total bilirubin was 15.67 (7.76) μmol/L. Compared to participants in Q2-Q3 of LgTBiL, there was a significantly increased prevalence of PAD for participants in both Q1 (OR, 1.49; 95% CI: 1.04-2.14) and Q4 (OR, 1.70; 95% CI: 1.16-2.48). After adjusting for potential confounders, a nonlinear U-shaped relationship was detected between TBiL and the prevalence of PAD, and the inflection point was calculated to be 1.08 (LgTBiL = 1.08, TBiL = 12.02 μmol/L). The ORs (95% CIs) were 0.11 (0.02, 0.83) on the left side of the inflection point and 5.26 (1.59, 17.38) on the right side of the inflection point. Similar results were found in various subgroups.Conclusions: This cross-sectional study showed that there was a U-shaped curve for the prevalence of PAD with TBiL concentration in Chinese males with hypertension, with a turning point at 12.02 μmol/L.

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U-Shaped Association Between Serum Bilirubin Levels and Peripheral Arterial Disease in Chinese Males with Hypertension

10.21203/rs.3.rs-40589/v1 ◽

2020 ◽

Author(s):

Yumeng Shi ◽

Lihua Hu ◽

Minghui Li ◽

Xiao Huang ◽

Congcong Ding ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Inflection Point ◽

Total Bilirubin ◽

Arterial Disease ◽

Cross Sectional Study ◽

Serum Total Bilirubin ◽

Cross Sectional ◽

Increased Risk ◽

Peripheral Arterial ◽

The Right

Abstract Background: Previous studies indicated that serum total bilirubin might play an important role in peripheral artery disease (PAD). However, the effects of different levels of serum total bilirubin (TBiL) on PAD development remain an uncertainty and had limited data in male participants. We aimed to examine the prevalence of PAD and TBiL among Chinese male adults with hypertension.Methods: A total of 5129 hypertension male subjects aged 27-93 years was included in the current study. The outcome was a peripheral arterial disease (PAD), defined as present when ABI of either sides was ≤ 0.90.Results: Of 5,129 hypertension male participants, 194 (3.78%) had PAD, and the median serum concentrations of TBiL were 14.10 μmol/L (interquartile range 11.00 to18.60 μmol/L). Compared to participants in Q2-Q3 of LgTBiL, there was a significantly increased risk of PAD for participants in both Q1 (OR,1.49; 95%CI: 1.04-2.14) and Q4 (OR,1.70; 95%CI: 1.16-2.48). After adjusting for potential confounders, a nonlinear U-shaped relationship was detected between TBiL and PAD, and calculated the inflection point was 1.08 (LgTBiL = 1.08, TBiL = 12.02 μmol/L). The ORs (95% CIs) were 0.11 (0.02, 0.83) on the left side of an inflection point and 5.26 (1.59, 17.38) on the right side of the inflection point, respectively. Similar results were found in various subgroups.Conclusions: This cross-sectional study had shown that there was a U-shaped curve for the risk of PAD with TBiL concentration in Chinese males with hypertension, with a turning point at 12.02 μmol/L.

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