scholarly journals Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants

2018 ◽  
Vol 38 (10) ◽  
pp. 2327-2337 ◽  
Author(s):  
Annakaisa Tirronen ◽  
Taina Vuorio ◽  
Sanna Kettunen ◽  
Krista Hokkanen ◽  
Bastian Ramms ◽  
...  
Keyword(s):  
Growth Factor ◽  
Angiogenic Growth Factor ◽  
Chylomicron Remnants

The significance of angiogenic growth factor in the pathogenesis of gestosis in pregnant women with varicose disease

2008 ◽  
Vol 145 (4) ◽  
pp. 480-482 ◽  
Author(s):  
A. V. Sokolyan ◽  
A. V. Murashko ◽  
L. V. Krechetova ◽  
M. M. Ziganshina ◽  
G. T. Sukhikh
Keyword(s):  
Growth Factor ◽  
Pregnant Women ◽  
Angiogenic Growth Factor ◽  
Varicose Disease

IMPACT OF CARDIOPLEGIC ARREST ON MYOCARDIAL ANGIOGENIC GROWTH FACTOR GENE EXPRESSION

2004 ◽  
Vol 13 (3) ◽  
pp. 126-127
Author(s):  
Uwe Fischer ◽  
Charles Cox ◽  
Steven Allen ◽  
Wilhelm Bloch ◽  
Uwe Mehlhorn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Cardioplegic Arrest ◽  
Angiogenic Growth Factor ◽  
Factor Gene ◽  
Growth Factor Gene

Effects of Angiogenic Growth Factor Combinations on Retinal Endothelial Cells☆

2002 ◽  
Vol 74 (4) ◽  
pp. 523-535 ◽  
Author(s):  
Raquel Castellon ◽  
Hamdi K Hamdi ◽  
Ingrid Sacerio ◽  
Annette M Aoki ◽  
M Cristina Kenney ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Angiogenic Growth Factor ◽  
Retinal Endothelial Cells

Muscle angiogenic growth factor gene responses to exercise in chronic renal failure

2001 ◽  
Vol 281 (2) ◽  
pp. R539-R546 ◽  
Author(s):  
Peter D. Wagner ◽  
Ferran Masanés ◽  
Harrieth Wagner ◽  
Ernest Sala ◽  
Oscar Miró ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Percutaneous Biopsy ◽  
Oxidative Capacity ◽  
Knee Extensors ◽  
Angiogenic Growth Factor ◽  
Vegf Mrna ◽  
Mitochondrial Oxidative Capacity

Patients with chronic renal failure (CRF) have impaired exercise capacity even after erythropoietin treatment. We recently showed that although this is explained in part by reduced convective O2 delivery to muscles, there is also an impairment of O2 transport from muscle capillaries to the mitochondria. Given the importance of the capillary surface area for capillary mitochondrial O2 transport and reports of reduced capillarity in CRF, we hypothesized that the angiogenic gene response to exercise is impaired in such patients. Six patients with CRF and six control subjects matched for age, size, and sedentary lifestyle exercised on a single occasion for 1 h at similar work intensities averaging 50% of maximal capacity. Exercise was confined to the knee extensors of a single leg by means of a specially designed leg-kick ergometer. A percutaneous biopsy of the quadriceps was taken within 30 min of cessation of exercise and compared with a similar biopsy done at different times without any prior exercise for 24 h. Conventional Northern blots were prepared and probed for vascular endothelial growth factor (VEGF; the major putative angiogenic growth factor for muscle), basic fibroblast growth factor (bFGF), and transforming growth factor (TGF)-β1. Data during both rest and exercise were successfully obtained in four subjects of each group. We also assessed muscle capillarity and mitochondrial oxidative capacity to relate to these changes. Mitochondrial oxidative capacity was normal, whereas capillary number per fiber was 12% lower than in normal subjects. VEGF mRNA abundance was increased after exercise by about one order of magnitude, with no reduction in response in CRF. For bFGF and TGF-β1, exercise elicited no response in either group. Reduced muscle capillarity in CRF does not, therefore, stem from reduced transcription of VEGF. To the extent that VEGF is important to exercise-induced angiogenesis in muscle, we suspect a posttranscriptional aberration in this response occurs in CRF to explain reduced capillarity.

scholarly journals A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice

Angiogenesis ◽  
2013 ◽  
Vol 17 (1) ◽  
pp. 207-219 ◽  
Author(s):  
Yung-Yi Chen ◽  
Nicola J. Brown ◽  
Rita Jones ◽  
Claire E. Lewis ◽  
Ahmed H. Mujamammi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Inflammatory Arthritis ◽  
Tumour Growth ◽  
Growth Factor Receptors ◽  
Angiogenic Growth Factor
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