IMPACT OF CARDIOPLEGIC ARREST ON MYOCARDIAL ANGIOGENIC GROWTH FACTOR GENE EXPRESSION

2004 ◽  
Vol 13 (3) ◽  
pp. 126-127
Author(s):  
Uwe Fischer ◽  
Charles Cox ◽  
Steven Allen ◽  
Wilhelm Bloch ◽  
Uwe Mehlhorn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Cardioplegic Arrest ◽  
Angiogenic Growth Factor ◽  
Factor Gene ◽  
Growth Factor Gene

Effect of NO, vasodilator prostaglandins, and adenosine on skeletal muscle angiogenic growth factor gene expression

1999 ◽  
Vol 86 (5) ◽  
pp. 1513-1518 ◽  
Author(s):  
H. Benoit ◽  
M. Jordan ◽  
H. Wagner ◽  
P. D. Wagner
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Regulation Of Gene Expression ◽  
Transforming Growth Factor Β1 ◽  
Angiogenic Growth Factor ◽  
Factor Gene ◽  
Growth Factor Gene

Exercise training results in several muscle adaptations, one of which is angiogenesis. Acutely, exercise leads to release of nitric oxide, prostacyclin (PGI2), and adenosine (A) in the skeletal muscles. In this paper, we asked whether any of these locally released vasodilators, as well as other known dilator prostaglandins (PGE1 and PGE2), have the potential to increase angiogenic growth factor gene expression in resting skeletal muscle. Seven groups of 5–7 female Wistar rats (age 8–12 wk, weight 250 ± 10 g) were anesthetized and instrumented for carotid artery pressure and electromagnetic femoral artery blood flow measurement. One group acted as control while the other groups each received one of the following six agents by constant arterial infusion (dose in μg/min): A (200), nitroprusside (NP, 4.2), acetylcholine (100), PGE1 (1.9), PGE2 (1.7), and PGI2 (1.7). Each agent reduced peripheral vascular resistance to a similar extent (at least twofold). Densitometric mRNA/18S levels for vascular endothelial growth factor (VEGF) were increased 50% by NP and acetylcholine, were unaffected by PGE1 and PGE2, and were reduced 40% by PGI2. For basic fibroblast growth factor, only PGI2 had any effect, reducing mRNA/18S ∼25%. For transforming growth factor-β1, A, NP, and PGE1 led to reduced mRNA/18S, whereas PGE2 slightly increased mRNA/18S. For the principal putative angiogenic growth factor, VEGF, these data suggest that naturally secreted vasodilators in contracting skeletal muscle could be involved in regulation of gene expression, namely, nitric oxide in a positive and PGI2 in a negative direction.

Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle

2002 ◽  
Vol 92 (3) ◽  
pp. 1176-1182 ◽  
Author(s):  
Timothy P. Gavin ◽  
Peter D. Wagner
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Factor ◽  
Acute Exercise ◽  
Muscle Growth ◽  
Angiogenic Growth Factor ◽  
Factor Gene ◽  
Skeletal Muscle Growth ◽  
Growth Factor Gene ◽  
Exercise Induced

Moderate ethanol consumption demonstrates a protective effect against cardiovascular disease and improves insulin sensitivity, possibly through angiogenesis. We investigated whether 1) ethanol would increase skeletal muscle growth factor gene expression and 2) the effects of ethanol on skeletal muscle growth factor gene expression were independent of exercise-induced growth factor gene expression. Female Wistar rats were used. Four groups (saline + rest; saline + exercise; 17 mmol/kg ethanol + rest; and 17 mmol/kg ethanol + exercise) were used to measure the growth factor response to acute exercise and ethanol administration. Vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), basic fibroblast growth factor (bFGF), Flt-1, and Flk-1 mRNA were analyzed from the left gastrocnemius by quantitative Northern blot. Ethanol increased VEGF, TGF-β1, bFGF, and Flt-1 mRNA at rest and after acute exercise. Ethanol increased resting Flk-1 mRNA. Ethanol increased bFGF mRNA independently of exercise. These findings suggest that 1) ethanol can increase skeletal muscle angiogenic growth factor gene expression and 2) the mechanisms responsible for the ethanol-induced increases in VEGF, TGFβ1, and Flt-1 mRNA appear to be different from those responsible for exercise-induced regulation. Therefore, these results provide evidence in adult rat tissue that the protective cardiovascular effects of moderate ethanol consumption may result in part through the increase of angiogenic growth factors.

scholarly journals Regulation of keratinocyte growth factor gene expression by interleukin 1.

1994 ◽  
Vol 269 (14) ◽  
pp. 10753-10757 ◽  
Author(s):  
M. Chedid ◽  
J.S. Rubin ◽  
K.G. Csaky ◽  
S.A. Aaronson
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Keratinocyte Growth Factor ◽  
Interleukin 1 ◽  
Factor Gene ◽  
Growth Factor Gene
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