Abstract 2344: Cumulative Radiation Dose Estimate From Medical Testing in Grown-Up Patients With Congenital Heart Disease

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Lamia Ait-Ali ◽  
Nicoletta Botto ◽  
Maria Grazia Andreassi ◽  
Pierluigi Festa ◽  
Eugenio Picano
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Effective Dose ◽  
Cumulative Dose ◽  
Congenital Heart ◽  
Cumulative Exposure ◽  
X Rays ◽  
Dose Estimate ◽  
Risk Of Cancer ◽  
Beir Vii

Background: The “Biological effects of Ionizing Radiation” (BEIR VII,2005) underlines “the need of studies of infants who are exposed to diagnostic radiation”. Aim: to assess the individual cumulative lifetime radiological dose in grown up congenital heart disease (GUCH) patients. Methods: In 41 consecutive operated GUCH patient (24 males, age= 27 ± 9 years old), followed in our outpatient clinic, a cumulative radiological history was collected with a structured questionnaire and access to lifetime hospital records. All patient underwent at least one surgical intervention during the infancy for Tetralogy of Fallot (n=18), aortic coarctation (n=10), anatomical/functional univentricular heart (n=8), other congenital heart disease (n=5) The cumulative exposure was expressed in milliSievert (mSv) and derived from average effective dose estimates of individual examinations proposed by the European Commission Medical Imaging Guidelines (2001). The attributable cancer risk was estimated from BEIR VII, 2005 document. Results: On average, cumulative dose estimate was 22.3 ± 12.4 (mean ± SD) mSv per patient, equivalent to about 1115 ± 620 chest x-rays. Diagnostic and interventional catheterization accounted for the most important sources of exposure (see figure ). The median cumulative dose gave an average extra-risk of cancer of about 1 out of 200 patients (range, 1 in 448 to 1 out of 58). Conclusion: the average contemporary GUCH patient is exposed to a significant cumulative radiological effective dose. Every effort should be done to justify the indications and to optimise dose delivery during ionizing testing.

Cumulative Exposure to Medical Radiation for Children Requiring Surgery for Congenital Heart Disease

2014 ◽  
Vol 164 (4) ◽  
pp. 789-794.e10 ◽  
Author(s):  
Andrew C. Glatz ◽  
Kristen S. Purrington ◽  
Amanda Klinger ◽  
Amanda R. King ◽  
Jeffrey Hellinger ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Cumulative Exposure ◽  
Medical Radiation

scholarly journals Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease

Heart ◽  
2009 ◽  
Vol 96 (4) ◽  
pp. 269-274 ◽  
Author(s):  
L. Ait-Ali ◽  
M. G. Andreassi ◽  
I. Foffa ◽  
I. Spadoni ◽  
E. Vano ◽  
...  
Keyword(s):  
Dna Damage ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Effective Dose ◽  
Congenital Heart ◽  
Acute Radiation ◽  
Chromosomal Dna ◽  
Radiation Induced

DIAGNOSIS AND TREATMENT: THE SALVAGE OF CRITICALLY ILL NEWBORN INFANTS WITH CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1968 ◽  
Vol 42 (1) ◽  
pp. 198-202
Author(s):  
Donald C. Fyler
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Critically Ill ◽  
Respiratory Symptoms ◽  
Congenital Heart ◽  
Newborn Infants ◽  
Accurate Diagnosis ◽  
X Rays ◽  
Blood Gas ◽  
Aggressive Surgical Approach

The natural course of congenital heart disease in the newborn infant may last only a few days or weeks; yet, many of these babies are salvageable through surgery. The clinician's problems include the necessity for early detection through recognition of persistant cyanosis or respiratory symptoms, exclusion of primary lung disease through chest x-rays and blood gas determinations, and establishing an accurate diagnosis as rapidly as possible through cardiac catheterization. An aggressive surgical approach to these critically ill infants can then result ill many survivors.

scholarly journals Risk of Cancer Among Children and Young Adults With Congenital Heart Disease Compared With Healthy Controls

2019 ◽  
Vol 2 (7) ◽  
pp. e196762 ◽  
Author(s):  
Zacharias Mandalenakis ◽  
Christina Karazisi ◽  
Kristofer Skoglund ◽  
Annika Rosengren ◽  
Georgios Lappas ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Young Adults ◽  
Heart Disease ◽  
Congenital Heart ◽  
Healthy Controls ◽  
Children And Young Adults ◽  
Risk Of Cancer

The utility of guaiac stool testing in the detection of gastrointestinal complications in infants with critical congenital heart disease

2019 ◽  
Vol 29 (5) ◽  
pp. 655-659 ◽  
Author(s):  
Melanie Muller ◽  
Cortney Foster ◽  
Jessica Lee ◽  
Caroline Bauer ◽  
Casey Bor ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Chart Review ◽  
Caloric Intake ◽  
Retrospective Chart Review ◽  
X Rays ◽  
Critical Congenital Heart Disease ◽  
Gastrointestinal Complications ◽  
Feeding Tolerance

AbstractBackground:Guaiac stool testing has been routinely used as a method to detect gastrointestinal complications in infants with critical congenital heart disease (CHD); however, the sensitivity and specificity have not been established.Methods:A retrospective chart review was performed investigating the presence of heme-positive stools and subsequent gastrointestinal complications as well as time to goal caloric intake and radiograph exposure.Results:The presence of heme-positive stools was not a statistically significant factor in patients with critical CHD that experienced gastrointestinal complications. Additionally, patients with heme-positive stools did undergo more abdominal X-rays than those with heme-negative stools.Conclusions:The routine use of guaiac stool testing in infants with critical CHD is not a predictor of possible gastrointestinal complications and leads to more radiograph exposure for the patient. Close clinical monitoring can be used to evaluate feeding tolerance in infants with critical CHD.

P1804Cancer in young patients with congenital heart disease: A registry-based, matched, prospective cohort study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Z Mandalenakis ◽  
C K Karazisi ◽  
K S Skoglund ◽  
A R Rosengren ◽  
G L Lappas ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Young Patients ◽  
Systematic Screening ◽  
Incidence Of Cancer ◽  
Increased Risk ◽  
Using Data ◽  
Risk Of Cancer

Abstract Background Adult patients with congenital heart disease (CHD) have an increased incidence of cancer presumably due to repeated radiation exposure, genetic predisposition or a continued stress factor during heart interventions. Purpose We aimed to investigate the risk to be diagnosed with cancer from birth up to the age of 42 years in patients with CHD and compared to matched controls. Methods Using data from the Patient and Cause of Death Registers in Sweden, we identified successive cohorts of patients with CHD born 1970–79, 1980–89 and 1990–93. Each CHD patient was matched for birth year, sex and county with 10 controls without CHD from the general population with follow-up data and comorbidities collected from birth until 2011. Results We identified 21,982 patients with CHD and 219,816 matched controls of whom 428 (1.95%) and 2,072 (0.94%), respectively, were diagnosed with cancer over a mean follow-up of 26.2 and 27.5 years. The overall hazard ratio (HR) for cancer was 2.24 times (95% confidence interval [CI], 2.01–2.48) in children and young adults with CHD compared to controls; higher in men (HR 2.41 (95% CI, 2.08–2.79)) and among patients with isolated atrial or ventricular defects, as well as in the large group of miscellaneous anomalies. The cumulative incidence of cancer in patients with CHD increased by birth cohort with almost 2% among those born 1990–93 been diagnosed with cancer on reaching adulthood. Conclusions Young patients with CHD had more than 2 timmes increased risk to develop cancer compared to matched controls. At the age of 42, 1 out of 50 patients with CHD developed cancer and the risk was significantly higher in men with CHD. The patient groups with atrial and ventricular septal defects had a significantly increased risk of cancer and a systematic screening for cancer could be considered to this vulnerable group of patients. Acknowledgement/Funding By grants from the Swedish state under the agreement concerning research and education of doctors, the Swedish Research Council.

Sign in / Sign up

Export Citation Format

Share Document