Abstract P308: γ-Glutamyltransferase and Mortality from Cardiovascular Disease: EPOCH-JAPAN

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Yuanying Li ◽  
Hiroyasu Iso ◽  
Renze Cui ◽  
Shinya Nagasawa ◽  
Yoshitaka Murakami ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Smoking Status ◽  
Cardiovascular Prevention ◽  
Health Examination ◽  
Multivariable Model ◽  
Japanese Men ◽  
Men And Women ◽  
Cvd Mortality

Background: Recently, γ-Glutamyltransferase (γ-GTP) has been positively associated with risk of cardiovascular disease (CVD), especially among non-drinkers. But the evidence is limited in Asian populations. The present study investigated the association between γ-GTP with mortality from ischemic stroke, hemorrhagic stroke and coronary heart disease in Japanese men and women, and further in non-drinkers. Methods: A total of 41,040 Japanese (men/women: 15,987/25,053) aged 40-79 years with no self-reported history of CVD at baseline from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) which is a pooled analysis comprising 13 well-qualified Japanese cohorts for examining the relationship between health examination measures and CVD mortality. Sex-specific hazard ratios(HRs) and their 95% confident intervals(CIs) of CVD mortality for one-standardized deviation increment of log-transformed γ-GTP were calculated by Cox hazard models, adjusting for age (continuous), smoking status (never, past, 1–20/day and ≥21/day), drinking status (never, past and current), and sex-specific quintiles of body mass index, triglycerides, total cholesterol, systolic blood pressure, aspartate transaminase and alanine transaminase in multivariable model. Results: During an average 8.7-year follow-up, there were 314 (146 men and 168 women) deaths from stroke, 154 (101men and 53 women) deaths from coronary heart disease, and 701 (361 men and 340 women) deaths from total CVD. A significant association was found in the multivariable model between γ-GTP and mortality form stroke and total CVD in men, and mortality from coronary heart disease and total CVD in women. The respective multivariable HRs (95% CI) were 1.36 (1.13–1.65) and 1.17 (1.03–1.33) in men, and 1.76 (1.36–2.28) and 1.33 (1.19–1.49) in women. Because the proportion of current drinkers was 73% in men and 29% in women, we further examined the associations in non-drinkers. The respective multivariable HRs (95% CI) were 1.58 (1.08–2.31) and 1.42 (1.13–1.80) in male non-drinkers and 1.72 (1.28–2.33) and 1.32 (1.16–1.51) in female non-drinkers. Conclusions: γ-GTP was positively associated with CVD mortality in both Japanese men and women, specifically in non-drinkers.

Non-alcoholic beverages intake and risk of cardiovascular disease among Japanese men and women: the JPHC study

2021 ◽  
pp. 1-20
Author(s):  
Renzhe Cui ◽  
Hiroyasu Iso ◽  
Ehab S Eshak ◽  
Koutatsu Maruyama ◽  
Junko Ishihara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cox Regression ◽  
Alcoholic Beverages ◽  
Tea Consumption ◽  
Japanese Men ◽  
Men And Women ◽  
Incident Cardiovascular Disease

Abstract The association between the intake of non-alcoholic beverages and cardiovascular disease in Asians is uncertain. The intake of non-alcoholic beverages was estimated in 77,407 participants of the Japan public health center-based cohort study aged 45-74 years. The Cox regression calculated the HRs and 95% CIs for incident cardiovascular disease according to sex-specific quintiles of intake of non-alcoholic beverages. A total of 4578 incident cardiovascular disease (3,751 strokes and 827 coronary heart disease) were diagnosed during a 13.6-year median follow-up. The risks of stroke and total cardiovascular disease were lower for the highest versus lowest intake quintiles of non-alcoholic beverages in men and women: the multivariable HRs (95%CIs) were 0.82 (0.71-0.93, p-trend=0.005) and 0.86 (0.76-0.97, p-trend=0.02), respectively in men, and were 0.73 (0.63-0.86, p-trend=0.003) and 0.75 (0.65-0.87, p-trend=0.005) respectively in women. The reduced risk was evident for both ischemic and hemorrhagic strokes and was mainly attributable to green tea consumption. The intake of non-alcoholic beverages from coffee and other beverages was not associated with the risk of cardiovascular disease in both men and women. Also, there was no association between the intake of non-alcohol beverages and the risk of coronary heart disease in either sex. In conclusion, the risks of stroke and total cardiovascular disease were lower with a higher intake of non-alcoholic beverages in Japanese men and women.

scholarly journals Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study

Stroke ◽  
2021 ◽  
Author(s):  
Satoyo Ikehara ◽  
Hiroyasu Iso ◽  
Yoshihiro Kokubo ◽  
Kazumasa Yamagishi ◽  
Isao Saito ◽  
...  
Keyword(s):  
Public Health ◽  
Cardiovascular Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Japanese Men ◽  
Food Frequency ◽  
Men And Women ◽  
History Of

Background and Purpose: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. Methods: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center–based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). Results: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77–0.93, P for trend=0.002) for total stroke, 0.80 (0.71–0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79–1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80–1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80–0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. Conclusions: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

scholarly journals Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women

Stroke ◽  
2008 ◽  
Vol 39 (11) ◽  
pp. 2936-2942 ◽  
Author(s):  
Satoyo Ikehara ◽  
Hiroyasu Iso ◽  
Hideaki Toyoshima ◽  
Chigusa Date ◽  
Akio Yamamoto ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Alcohol Consumption ◽  
Japanese Men ◽  
Men And Women

Serum Triglycerides and Risk of Coronary Heart Disease among Japanese Men and Women

2001 ◽  
Vol 153 (5) ◽  
pp. 490-499 ◽  
Author(s):  
Hiroyasu Iso ◽  
Yoshihiko Naito ◽  
Shinichi Sato ◽  
Akihiko Kitamura ◽  
Tomonori Okamura ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Serum Triglycerides ◽  
Japanese Men ◽  
Men And Women

Salt preference and mortality from stroke and coronary heart disease for Japanese men and women: The JACC study

2012 ◽  
Vol 54 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Satoyo Ikehara ◽  
Hiroyasu Iso ◽  
Chigusa Date ◽  
Shogo Kikuchi ◽  
Yoshiyuki Watanabe ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Japanese Men ◽  
Men And Women

scholarly journals Sex Differences in Coronary Artery Calcium and Mortality from Coronary Heart Disease, Cardiovascular Disease, and All Causes in Adults with Diabetes: The Coronary Calcium Consortium

2020 ◽  
Author(s):  
Nathan D Wong ◽  
Amber R Cordola Hsu ◽  
Alan Rozanski ◽  
Leslee J Shaw ◽  
Seamus P. Whelton ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Cox Regression ◽  
Total Mortality ◽  
Design And Methods ◽  
Cvd Mortality

<b>Objective:</b> While diabetes mellitus (DM) has been previously noted to be a stronger risk factor for cardiovascular disease (CVD) in women compared to men, it is not clear if this still the case. Coronary artery calcium (CAC) predicts coronary heart disease (CHD) and CVD in persons with DM; however, its sex-specific impact is less defined. We compared the relation of CAC in women versus men with DM for total, CVD, and CHD mortality. <p><b>Research Design and Methods:</b> We studied adults with DM from a large registry of patients with CAC scanning with mortality follow-up over 11.5 years. Cox regression examined the relation of CAC with mortality endpoints. </p> <p><b>Results:</b> Among 4,503 adults with DM (32.5% women) aged 21-93 years, 61.2% of women and 80.4% of men had CAC>0. Total, CVD, and CHD mortality rates were directly related to CAC; women had higher total and CVD death rates than men when CAC>100. Age and risk factor-adjusted hazard ratios (HRs) per log unit CAC were higher among women versus men for total (1.36 vs. 1.21) and CVD mortality (1.67 vs. 1.33) (interaction p=0.01 for both) but similar for CHD mortality (1.53 and 1.48). For CVD mortality, HR’s with CAC scores of 101-400 and >400 were 3.67 and 6.27, respectively for women and 1.63 and 3.48, respectively for men (interaction p=0.04). For total mortality HRs were 2.56 and 4.05 for women, respectively, and 1.88 and 2.66 for men, respectively (interaction p=0.01). </p> <p><b>Conclusion:</b> CAC predicts CHD, CVD, and all-cause mortality in patients with DM; however, greater CAC predicts CVD and total mortality more strongly in women.<b> </b></p>

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