Non-alcoholic beverages intake and risk of cardiovascular disease among Japanese men and women: the JPHC study

2021 ◽  
pp. 1-20
Author(s):  
Renzhe Cui ◽  
Hiroyasu Iso ◽  
Ehab S Eshak ◽  
Koutatsu Maruyama ◽  
Junko Ishihara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cox Regression ◽  
Alcoholic Beverages ◽  
Tea Consumption ◽  
Japanese Men ◽  
Men And Women ◽  
Incident Cardiovascular Disease

Abstract The association between the intake of non-alcoholic beverages and cardiovascular disease in Asians is uncertain. The intake of non-alcoholic beverages was estimated in 77,407 participants of the Japan public health center-based cohort study aged 45-74 years. The Cox regression calculated the HRs and 95% CIs for incident cardiovascular disease according to sex-specific quintiles of intake of non-alcoholic beverages. A total of 4578 incident cardiovascular disease (3,751 strokes and 827 coronary heart disease) were diagnosed during a 13.6-year median follow-up. The risks of stroke and total cardiovascular disease were lower for the highest versus lowest intake quintiles of non-alcoholic beverages in men and women: the multivariable HRs (95%CIs) were 0.82 (0.71-0.93, p-trend=0.005) and 0.86 (0.76-0.97, p-trend=0.02), respectively in men, and were 0.73 (0.63-0.86, p-trend=0.003) and 0.75 (0.65-0.87, p-trend=0.005) respectively in women. The reduced risk was evident for both ischemic and hemorrhagic strokes and was mainly attributable to green tea consumption. The intake of non-alcoholic beverages from coffee and other beverages was not associated with the risk of cardiovascular disease in both men and women. Also, there was no association between the intake of non-alcohol beverages and the risk of coronary heart disease in either sex. In conclusion, the risks of stroke and total cardiovascular disease were lower with a higher intake of non-alcoholic beverages in Japanese men and women.

Abstract P308: γ-Glutamyltransferase and Mortality from Cardiovascular Disease: EPOCH-JAPAN

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Yuanying Li ◽  
Hiroyasu Iso ◽  
Renze Cui ◽  
Shinya Nagasawa ◽  
Yoshitaka Murakami ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Smoking Status ◽  
Cardiovascular Prevention ◽  
Health Examination ◽  
Multivariable Model ◽  
Japanese Men ◽  
Men And Women ◽  
Cvd Mortality

Background: Recently, γ-Glutamyltransferase (γ-GTP) has been positively associated with risk of cardiovascular disease (CVD), especially among non-drinkers. But the evidence is limited in Asian populations. The present study investigated the association between γ-GTP with mortality from ischemic stroke, hemorrhagic stroke and coronary heart disease in Japanese men and women, and further in non-drinkers. Methods: A total of 41,040 Japanese (men/women: 15,987/25,053) aged 40-79 years with no self-reported history of CVD at baseline from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) which is a pooled analysis comprising 13 well-qualified Japanese cohorts for examining the relationship between health examination measures and CVD mortality. Sex-specific hazard ratios(HRs) and their 95% confident intervals(CIs) of CVD mortality for one-standardized deviation increment of log-transformed γ-GTP were calculated by Cox hazard models, adjusting for age (continuous), smoking status (never, past, 1–20/day and ≥21/day), drinking status (never, past and current), and sex-specific quintiles of body mass index, triglycerides, total cholesterol, systolic blood pressure, aspartate transaminase and alanine transaminase in multivariable model. Results: During an average 8.7-year follow-up, there were 314 (146 men and 168 women) deaths from stroke, 154 (101men and 53 women) deaths from coronary heart disease, and 701 (361 men and 340 women) deaths from total CVD. A significant association was found in the multivariable model between γ-GTP and mortality form stroke and total CVD in men, and mortality from coronary heart disease and total CVD in women. The respective multivariable HRs (95% CI) were 1.36 (1.13–1.65) and 1.17 (1.03–1.33) in men, and 1.76 (1.36–2.28) and 1.33 (1.19–1.49) in women. Because the proportion of current drinkers was 73% in men and 29% in women, we further examined the associations in non-drinkers. The respective multivariable HRs (95% CI) were 1.58 (1.08–2.31) and 1.42 (1.13–1.80) in male non-drinkers and 1.72 (1.28–2.33) and 1.32 (1.16–1.51) in female non-drinkers. Conclusions: γ-GTP was positively associated with CVD mortality in both Japanese men and women, specifically in non-drinkers.

scholarly journals Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

2021 ◽  
Vol 8 ◽  
Author(s):  
Gang-Qiong Liu ◽  
Wen-Jing Zhang ◽  
Jia-Hong Shangguan ◽  
Xiao-Dan Zhu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Major Adverse Cardiovascular Events ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
The Third

Aims: The present study aimed to investigate the prognostic role of derived neutrophil-to-lymphocyte ratio (dNLR) in patients with coronary heart disease (CHD) after PCI.Methods: A total of 3,561 post-PCI patients with CHD were retrospectively enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The patients (3,462) were divided into three groups according to dNLR tertiles: the first tertile (dNLR < 1.36; n = 1,139), second tertile (1.36 ≥ dNLR < 1.96; n = 1,166), and third tertile(dNLR ≥ 1.96; n = 1,157). The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint was defined as mortality (including all-cause death and cardiac death), and the secondary endpoint was major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).Results: There were 2,644 patients with acute coronary syndrome (ACS) and 838 patients with chronic coronary syndrome (CCS) in the present study. In the total population, the all-cause mortality (ACM) and cardiac mortality (CM) incidence was significantly higher in the third tertile than in the first tertile [hazard risk (HR) = 1.8 (95% CI: 1.2–2.8), p = 0.006 and HR = 2.1 (95% CI: 1.23–3.8), p = 0.009, respectively]. Multivariate Cox regression analyses suggested that compared with the patients in the first tertile than those in the third tertile, the risk of ACM was increased 1.763 times (HR = 1.763, 95% CI: 1.133–2.743, p = 0.012), and the risk of CM was increased 1.763 times (HR = 1.961, 95% CI: 1.083–3.550, p = 0.026) in the higher dNLR group during the long-term follow-up. In both ACS patients and CCS patients, there were significant differences among the three groups in the incidence of ACM in univariate analysis. We also found that the incidence of CM was significantly different among the three groups in CCS patients in both univariate analysis (HR = 3.541, 95% CI: 1.154–10.863, p = 0.027) and multivariate analysis (HR = 3.136, 95% CI: 1.015–9.690, p = 0.047).Conclusion: The present study suggested that dNLR is an independent and novel predictor of mortality in CHD patients who underwent PCI.

scholarly journals Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study

Stroke ◽  
2021 ◽  
Author(s):  
Satoyo Ikehara ◽  
Hiroyasu Iso ◽  
Yoshihiro Kokubo ◽  
Kazumasa Yamagishi ◽  
Isao Saito ◽  
...  
Keyword(s):  
Public Health ◽  
Cardiovascular Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Japanese Men ◽  
Food Frequency ◽  
Men And Women ◽  
History Of

Background and Purpose: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. Methods: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center–based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). Results: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77–0.93, P for trend=0.002) for total stroke, 0.80 (0.71–0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79–1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80–1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80–0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. Conclusions: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

scholarly journals Daily Total Physical Activity and Incident Cardiovascular Disease in Japanese Men and Women

Circulation ◽  
2017 ◽  
Vol 135 (15) ◽  
pp. 1471-1473 ◽  
Author(s):  
Yasuhiko Kubota ◽  
Hiroyasu Iso ◽  
Kazumasa Yamagishi ◽  
Norie Sawada ◽  
Shoichiro Tsugane
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Total Physical Activity ◽  
Japanese Men ◽  
Men And Women ◽  
Incident Cardiovascular Disease ◽  
Daily Total

scholarly journals Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women

Stroke ◽  
2008 ◽  
Vol 39 (11) ◽  
pp. 2936-2942 ◽  
Author(s):  
Satoyo Ikehara ◽  
Hiroyasu Iso ◽  
Hideaki Toyoshima ◽  
Chigusa Date ◽  
Akio Yamamoto ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Alcohol Consumption ◽  
Japanese Men ◽  
Men And Women

scholarly journals Comparison of Cystatin C and Creatinine as Predictors of Cardiovascular Events in a Community-Based Elderly Population

2010 ◽  
Vol 56 (5) ◽  
pp. 799-804 ◽  
Author(s):  
John Beilby ◽  
Mark L Divitini ◽  
Matthew W Knuiman ◽  
Enrico Rossi ◽  
Joseph Hung
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Renal Function ◽  
Heart Disease ◽  
Creatinine Clearance ◽  
Cystatin C ◽  
Cardiovascular Events ◽  
Community Based ◽  
Hazard Ratios

Abstract Background: Reduced renal function is an established risk factor for cardiovascular events. We compared 3 measures of renal function—serum cystatin C, serum creatinine, and calculated creatinine clearance—as predictors of subsequent cardiovascular events in a community-based population of elderly individuals. Methods: Comprehensive cardiovascular risk factor data were available for 1410 surviving participants of previous Busselton health surveys who were ≥60 years old. Hazard ratios for risk of incident coronary heart disease and cardiovascular disease over 10 years of follow-up were derived for each baseline measure of renal function by use of Cox regression. Results: All measures of renal function were significantly related to risks of morbidity and mortality from coronary heart disease and cardiovascular disease. There were 453 incident cardiovascular disease events; and the age- and sex-adjusted hazard ratios (95% CIs) were 1.34 (1.23–1.46), 1.32 (1.20–1.45), and 1.22 (1.06–1.41) per 1-SD deterioration in cystatin C, creatinine, and creatinine clearance, respectively. All 3 measures gave approximately the same age-adjusted relative risk estimates. After further adjustment for established cardiovascular risk factors, the relative risk estimates were all reduced but remained statistically significant (P < 0.05). Cystatin C was not a significant predictor for cardiovascular disease after adjustment for creatinine clearance. Conclusions: In relation to predicting risk for coronary heart disease or cardiovascular disease over a 10-year follow-up in a community-based population of elderly subjects, there was no evidence that cystatin C was a better risk predictor than creatinine or creatinine clearance.

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