Abstract P433: Emerging Lifestyle Factors Predict Carotid Intimal Media Thickness Scores

Introduction: Cardiovascular disease (CVD) remains the number one cause of mortality in the western world. Carotid intimal media thickness (carotid IMT) is a safe and reliable predictor of future CVD risk. Hypothesis: The study aims to assess the hypothesis that lifestyle factors impact carotid IMT, and determine which nutrition and fitness risk factors best predict mean carotid IMT scores. Methods: A prospective cross-sectional analysis of 592 men and women undergoing health and cardiovascular risk screening. This study reflects the first visit of these subjects, age 23 to 65 (mean = 48.2), who are followed longitudinally and who were participants at a “wellness” oriented program for patients who are generally well-educated and mostly in good health. Measurements were made of fitness using VO2max stress testing and push-up and sit-up scores following the American College of Sports Medicine testing protocols, diet intake using a 3-day dietary intake survey and computerized analyses. Mean carotid IMT scores were obtained using high resolution B-mode ultrasonography of the common carotid arteries. Each subject had ≥10 images collected from the far wall of the right and left distal 1 cm of the common carotid arteries at end diastole. The carotid intimal thickness was measured as a continuous variable, using both multivariate linear and bivariate linear regression. Multivariate analyses adjusted for potential confounders using multiple linear regression and included measures of body composition, blood pressure, fasting lipid and glucose levels, and statin use. Results: Multivariate analyses show that higher mean carotid IMT values are associated with increasing age (p<0.0001), male gender (p<.0.0001), lower aerobic capacity (p=0.0045), lower intake of fish (p=0.05), and lower intake of zinc (p=0.0002). Bivariate analyses controlling for age and gender, with and without statin use, showed higher mean carotid IMT scores were statistically associated with lower levels of aerobic fitness, (p = 0.0007), lower intake of fiber (p=0.02) and lower intake of magnesium (p=0.019). Intake of protein, carbohydrate, and fat as percent of calories; as well as intake of saturated fat, sodium, calcium, potassium, and vitamin K; measures of strength (assessed with push-up and sit-up testing); and self-reported exercise minutes per week were not associated with mean carotid IMT scores. Conclusions: In this database, aerobic fitness and dietary intake of fiber, fish, magnesium, and zinc are associated with lower carotid IMT scores. Further studies are warranted to explore the impact of emerging lifestyle factors on cardiovascular risk and clinical outcomes.

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Endothelial nitric oxide synthase Glu298→Asp polymorphism, carotid atherosclerosis and intima-media thickness in a general population sample

Clinical Science ◽

10.1042/cs20050090 ◽

2005 ◽

Vol 109 (5) ◽

pp. 475-481 ◽

Cited By ~ 19

Author(s):

Birger Wolff ◽

Claudia Braun ◽

Christina Schlüter ◽

Hans J. Grabe ◽

Katrin Popowski ◽

...

Keyword(s):

Endothelial Nitric Oxide Synthase ◽

Carotid Arteries ◽

Carotid Atherosclerosis ◽

Intima Media Thickness ◽

Atherosclerotic Plaques ◽

Carotid Imt ◽

The Common ◽

Oxide Synthase ◽

Endothelial Nitric Oxide ◽

Common Carotid Arteries

The Glu298→Asp (E298D; 894G→T) polymorphism of eNOS (endothelial nitric oxide synthase) has been related with cardiovascular disease. In the present study, we investigated the association of Glu298→Asp with atherosclerotic plaques in different carotid vessel segments and with carotid IMT (intima-media thickness). The Glu298→Asp eNOS polymorphism was determined by 5′-exonuclease assay among 2448 participants of the SHIP (Study of Health in Pomerania). Mean and maximum common carotid IMT, as well as carotid atherosclerosis, were measured by high-resolution ultrasound. The Asp/Asp298 genotype was associated with an increased risk of atherosclerotic plaques at the level of the common carotid arteries [multivariate odds ratio, 1.57 and 95% CI (confidence interval), 1.05–2.34; P=0.025], but not in the carotid bifurcations or internal or external carotid arteries. Glu298→Asp genotype was not associated with carotid IMT in the whole sample. However, the Asp/Asp298 genotype was independently associated with both higher mean [adjusted increase by 0.046 mm (95% CI, 0.013–0.078); P=0.006] and maximum carotid IMT [0.137 mm (95% CI, 0.064–0.209); P<0.001] in the low-risk group of subjects without carotid atherosclerosis. In conclusion, the Asp/Asp298 genotype is associated with atherosclerosis in the common carotid arteries and, in a low-risk group, also with carotid IMT. This suggests that the association of the Glu298→Asp genotype with atherosclerosis in the carotid arteries is site-specific and is modified by overall cardiovascular risk.

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Bilateral Displacement of the Common Carotid Arteries by a Large Goiter

Cureus ◽

10.7759/cureus.3298 ◽

2018 ◽

Author(s):

Lexian J McBain ◽

Joe Iwanaga ◽

Rod J Oskouian ◽

Marios Loukas ◽

R. Shane Tubbs

Keyword(s):

Carotid Arteries ◽

Large Goiter ◽

The Common ◽

Common Carotid Arteries

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Effect of a six-month treatment with lanreotide on cardiovascular risk factors and arterial intima-media thickness in patients with acromegaly

Acta Endocrinologica ◽

10.1530/eje.0.1460303 ◽

2002 ◽

pp. 303-309 ◽

Cited By ~ 49

Author(s):

A Colao ◽

P Marzullo ◽

G Lombardi

Keyword(s):

Cardiovascular Risk ◽

Disease Control ◽

Carotid Arteries ◽

Glycosylated Hemoglobin ◽

Hdl Cholesterol ◽

Intima Media Thickness ◽

Media Thickness ◽

Igf I ◽

The Right ◽

Common Carotid Arteries

OBJECTIVE: To evaluate the effect of a 6-month treatment with slow-release lanreotide (LAN) on cardiovascular risk and atherosclerosis in 24 normotensive patients with active acromegaly (GH=67.4 +/- 12.6 mU/l, IGF--I=866.0 +/- 55.8 microg/l) and 24 healthy subjects sex-, age- and body mass index-matched with the patients (as controls). DESIGN: Open, prospective, multicenter. METHODS: The following were measured before and after 6 months of LAN treatment (dose 60-90 mg/month): fasting GH, IGF-I, LDL, HDL and total cholesterol, triglyceride, glucose, glycosylated hemoglobin, insulin and fibrinogen levels, intima-media thickness (IMT) and blood systolic and diastolic peak velocity (SPV and DPV respectively) in both common carotids. RESULTS: At study entry, insulin, total and LDL cholesterol, triglyceride and fibrinogen levels were higher while HDL cholesterol levels were lower in patients than in controls. At the right (0.88 +/- 0.04 vs 0.77 +/- 0.03 mm, P=0.05) and left (0.93 +/- 0.03 vs 0.78 +/- 0.02 mm, P=0.01) common carotid IMT was significantly higher in patients than in controls; 12 patients and two controls showed an IMT of > or = 1 mm (chi(2)=8.2, P=0.004). After 6 months of LAN treatment, disease control was achieved in 15 patients (62.5%). Insulin, triglyceride and fibrinogen levels were significantly decreased, and a trend toward a decrease of IMT in the right (from 0.90 +/- 0.05 to 0.78 +/- 0.04 mm, P=0.06) and left (from 0.95 +/- 0.04 to 0.84 +/- 0.04 mm, P=0.06) common carotid arteries was observed only in patients with disease control, while SPV and DPV did not change. CONCLUSIONS: LAN treatment for 6 months significantly lowered GH, IGF-I, insulin and fibrinogen levels and reduced IMT of both common carotid arteries in normotensive patients with acromegaly.

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Elastolysis Following Partial Constriction of the Common Carotid Arteries of Rabbits

Journal of Electron Microscopy ◽

10.1093/oxfordjournals.jmicro.a050394 ◽

1983 ◽

Keyword(s):

Carotid Arteries ◽

The Common ◽

Common Carotid Arteries

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Doppler Assessment of the Effect of Chewing Qat on Hemodynamics of the Common Carotid Arteries

Journal of Medical Sciences(Faisalabad) ◽

10.3923/jms.2017.95.101 ◽

2017 ◽

Vol 17 (2) ◽

pp. 95-101 ◽

Cited By ~ 1

Author(s):

Mohamed Ibrahim ◽

Bushra Hussein A. Malik ◽

Moawia Gameraddin

Keyword(s):

Carotid Arteries ◽

The Common ◽

Common Carotid Arteries

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Secondary Flow in the Human Common Carotid Artery Imaged by MR Angiography

Journal of Biomechanical Engineering ◽

10.1115/1.2895439 ◽

1992 ◽

Vol 114 (1) ◽

pp. 147-149 ◽

Cited By ~ 24

Author(s):

C. G. Caro ◽

C. L. Dumoulin ◽

J. M. R. Graham ◽

K. H. Parker ◽

S. P. Souza

Keyword(s):

Human Subject ◽

Mr Angiography ◽

Carotid Arteries ◽

Three Dimensional ◽

Flow Imaging ◽

Dynamic Flow ◽

Healthy Human Subject ◽

Healthy Human ◽

The Common ◽

Common Carotid Arteries

The blood flow in arteries affects both the biology of the vessels and the development of atherosclerosis. The flow is three dimensional, unsteady, and difficult to measure or to model computationally. We have used phase-shift-based magnetic resonance angiography to image and measure the flow in the common carotid arteries of a healthy human subject. There was curvature of the vessels and thin-slice dynamic flow imaging showed evidence of the presence of secondary motions. Flexing the cervical spine straightened the vessels and reduced the asymmetry of the flow.

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Vascular Doppler ultrasonographic indices in cirrhosis: a case–control study with emphasis on the common carotid arteries

La radiologia medica ◽

10.1007/s11547-015-0524-2 ◽

2015 ◽

Vol 120 (10) ◽

pp. 982-988

Author(s):

Abolhassan Shakeri ◽

Mojtaba Varshochi ◽

Naser Atapour ◽

Masoud Nemati ◽

Manoochehr Khoshbaten ◽

...

Keyword(s):

Carotid Arteries ◽

Case Control Study ◽

Case Control ◽

The Common ◽

Common Carotid Arteries ◽

Control Study

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The influence of ligating one of the common carotid arteries upon handedness in the rat.

Journal of Comparative Psychology ◽

10.1037/h0071618 ◽

1932 ◽

Vol 14 (1) ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

G. M. Peterson

Keyword(s):

Carotid Arteries ◽

The Common ◽

Common Carotid Arteries

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Dependence of the efficiency of the initial state of fosinopril structure common carotid arteries, intravascular blood flow and central hemodynamics at patients with arterial hypertension

Systemic Hypertension ◽

10.26442/sg29097 ◽

2015 ◽

Vol 12 (3) ◽

pp. 30-33

Author(s):

L V Melnikova ◽

L F Bartosh ◽

O A Grechishkina

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Carotid Arteries ◽

Peak Flow ◽

Peripheral Resistance ◽

Initial State ◽

Central Hemodynamic ◽

Functional Features ◽

The Common ◽

Common Carotid Arteries

Aim. To study changes in structural and functional features of the common carotid arteries and central hemodynamic parameters under the influence of fosinopril at hypertensive patients depending on achieving target blood pressure.Material and methods. The study included 116 patients with essential hypertension. All patients underwent a general clinical study, an ultrasound scan of the common carotid arteries (CCA ) with the assessment of the structure and intravascular blood flow, and echocardiography with the definition of the parameters of central hemodynamic and intravascular, ambulatory blood pressure monitoring (ABPM) before the study and after 24 weeks of antihypertensive therapy angiotensin - converting enzyme fosinopril. Two groups of patients: the first group consisted of 74 people with the achievement of the targets of blood pressure (BP), the second 42 people who have not been achieved target BP levels.Results. In the first group there was a statistically significant decrease in the proportion of peripheral resistance, increased systolic index, distensibility coefficient of the common carotid arteries peak flow velocity. In the second group specific peripheral resistance was significantly increased, the thickness of the intima-media increased, decreased peak flow velocity.Conclusion. Effectiveness depends on fosinopril initial state total peripheral resistance, cardiac output, structural and functional features elastic arteries.

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