Vascular Doppler ultrasonographic indices in cirrhosis: a case–control study with emphasis on the common carotid arteries

Abstract Background Associations between IKZF1 gene variants and Acute Lymphoblastic Leukemia (ALL) was recently reported. We examined whether the common IKZF1 polymorphisms rs4132601 T/G and rs111978267 A/G are associated with ALL among a Tunisian pediatric cohort. Methods This case-control study involved 170 patients with ALL and 150 control subjects. SNP genotyping was performed by TaqMan® SNP Genotyping Assay. Results The minor allele G of IKZF1 gene polymorphism rs4132601 T/G was significantly higher in ALL cases than in control subjects (P = 0.029), with 1.54-fold increased risk of ALL. The association of rs4132601 with ALL was seen under co-dominant (P = 0.009), recessive (P = 0.006), and additive (P = 0.027) genetic models, of which the co-dominant (P = 0.027) and recessive (P = 0.027) association remained significant after adjusting for covariates, and False Discovery Rate correction. In contrast, no association was noted for rs111978267 variant. Two-locus (rs4132601-rs11978267) IKZF1 haplotype analysis demonstrated association of GA (P = 0.053), with increased ALL risk [OR (95% CI) = 1.58 (1.00–2.51)], which remained significant after controlling for key covariates [aP = 0.046; aOR (95% CI) = 1.61 (1.01–2.57)]. Conclusion We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.

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Use of an ingredient-based analysis to investigate a national outbreak of Escherichia coli O157, United Kingdom, July 2016

Eurosurveillance ◽

10.2807/1560-7917.es.2018.23.26.1700627 ◽

2018 ◽

Vol 23 (26) ◽

Cited By ~ 1

Author(s):

Daniel Gardiner ◽

Maya Gobin ◽

Neville Q Verlander ◽

Isabel Oliver ◽

Jeremy Hawker

Keyword(s):

Escherichia Coli ◽

Case Control Study ◽

Multivariable Analysis ◽

Case Control ◽

Escherichia Coli O157 ◽

Online Questionnaire ◽

Menu Item ◽

Retrospective Case ◽

The Common ◽

Control Study

Public Health England was alerted to a national outbreak of Shiga toxin-producing Escherichia coli O157 PT34 in July 2016. Early investigations suggested that the likely source was a salad item consumed outside of the home. A number of cases reported consuming meals at a staff canteen (Venue A) and a garden café (Venue B). Both venues shared a common salad supplier. An investigation was undertaken to measure associations between salad items and illness using an 'ingredient-based analysis'. A retrospective case–control study was conducted using an online questionnaire to collect information on menu items consumed at each venue. Chefs at both venues were interviewed to identify ingredients contained within each menu item. Both venues were pooled together for multivariable analysis measuring associations at the ingredient level. Among 203 responses, 24 cases were identified (13 confirmed, two probable and nine possible). Case onsets ranged between 7 and 25 June 2016. Multivariable analysis identified strong evidence that only baby mixed-leaf salad from the common supplier was a vehicle of infection (adjusted odds ratio = 13.1; 95% confidence interval: 1.6–106.5). Identifying the specific salad ingredient associated with illness was made possible by using an ingredient-based analysis. We recommend the increased use of ingredient-based analyses.

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The Common Variant rs1447295 on Chromosome 8q24 and Prostate Cancer Risk: Results from an Australian Population-Based Case-Control Study

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-06-0872 ◽

2007 ◽

Vol 16 (3) ◽

pp. 610-612 ◽

Cited By ~ 56

Author(s):

Gianluca Severi ◽

Vanessa M. Hayes ◽

Emma J.D. Padilla ◽

Dallas R. English ◽

Melissa C. Southey ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Prostate Cancer Risk ◽

Population Based ◽

Case Control ◽

Australian Population ◽

The Common ◽

Chromosome 8Q24 ◽

Control Study

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Wall stress of the cervical carotid artery in patients with carotid dissection: a case-control study

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00871.2010 ◽

2011 ◽

Vol 300 (4) ◽

pp. H1451-H1458 ◽

Cited By ~ 16

Author(s):

Fraser M. Callaghan ◽

Roger Luechinger ◽

Vartan Kurtcuoglu ◽

Hakan Sarikaya ◽

Dimos Poulikakos ◽

...

Keyword(s):

Carotid Arteries ◽

Case Control Study ◽

Carotid Sinus ◽

Wall Stress ◽

Head Rotation ◽

Case Control ◽

Head Movements ◽

Carotid Dissection ◽

Artery Wall ◽

Control Study

Spontaneous internal carotid artery (ICA) dissection (sICAD) results from an intimal tear located around the distal carotid sinus. The mechanisms causing the tear are unknown. This case-control study tested the hypotheses that head movements increase the wall stress in the cervical ICA and that the stress increase is greater in patients with sICAD than in controls. Five patients with unilateral, recanalized, left sICAD and five matched controls were investigated before and after maximal head rotation to the left and neck hyperextension after 45° head rotation to the left. The anatomy of the extracranial carotid arteries was assessed by magnetic resonance imaging and used to create finite element models of the right ICA. Wall stress increased after head movements. Increases above the 80th and 90th percentile were located at the intimal side of the artery wall from 7.4 mm below to 10 mm above the cranial edge of the carotid sinus, i.e., at the same location as histologically confirmed tears in patients with sICAD. Wall stress increase did not differ between patients and controls. The present findings suggest that wall stress increases at the intimal side of the artery wall surrounding the distal edge of the carotid bulb after head movements may be important for the development of carotid dissection. The lack of wall stress difference between the two groups indicates that the carotid arteries of patients with carotid dissection have either distinct functional or anatomical properties or endured unusually heavy wall stresses to initiate dissection.

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