Abstract 12503: Synchrotron Radiation Coronary Microangiography for Evaluating Changes in the Caliber of the in vivo Rat Coronary Artery After Endothelin Administration

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Hiroaki Sakamoto ◽  
Shonosuke Matsushita ◽  
Kazuyuki Hyodo ◽  
Chiho Tokunaga ◽  
Fujio Sato ◽  
...  
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Synchrotron Radiation ◽  
Regenerative Medicine ◽  
Ischemic Heart Disease ◽  
Coronary Arteries ◽  
High Energy ◽  
Ischemic Heart ◽  
Density Resolution

Background: Conventional coronary angiography can visualize vessels of 300 μm in diameter, but not those of smaller diameter, such as the proliferating collateral arteries of ischemic heart disease and the new blood vessels formed in regenerative medicine. We have developed a system of synchrotron radiation coronary microangiography (SRCA) in the in vivo rat. The purpose of this study was to define the minimum detectable caliber change in the coronary arteries of the in vivo rat by inducing vasoconstriction with endothelin during SRCA. Method: SRCA was performed at the Photon Factory of the High Energy Accelerator Research Organization (Tsukuba, Japan). The advantages of synchrotron radiation derived X-rays are high spatial resolution (5 μm/pixel) due to increased photon density and straightness of beam. High density resolution is obtained with a high-gain avalanche rushing amorphous photoconductor camera using a fiber-optic plate. Rats were anesthetized. The polyethylene tube for angiography was inserted into the carotid artery. SRCA was performed before and after endothelin administration. Results: The electrocardiography showed ST elevation after endothelin administration. High spatial and density resolution images were obtained. Figures A and B show the changes in the caliber of the coronary arteries: Figure A shows the arteries before endothelin administration, and Figure B shows them after endothelin administration. The minimum identified coronary artery diameter in the in vivo rat was 65 μm, and the minimum detectable caliber change was 20 μm. Conclusion: The SRCA system could confirm the microvascular constriction of the coronary arteries in the in vivo rat after endothelin administration. We plan next to use SRCA to evaluate endothelial dysfunction in diabetic rats. SRCA may aid investigation of collateral artery proliferation in ischemic heart disease and new blood vessel formation in regenerative medicine in the near future.

Gender Differences in Non-Obstructive Coronary Artery Disease

2020 ◽  
Vol 26 ◽  
Author(s):  
Maria Bergami ◽  
Marialuisa Scarpone ◽  
Edina Cenko ◽  
Elisa Varotti ◽  
Peter Louis Amaduzzi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Gender Differences ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Coronary Arteries ◽  
Obstructive Coronary Artery Disease ◽  
Ischemic Heart ◽  
Current Evidence ◽  
Artery Disease

: Subjects affected by ischemic heart disease with non-obstructive coronary arteries constitute a population that has received increasing attention over the past two decades. Since the first studies with coronary angiography, female patients have been reported to have non-obstructive coronary artery disease more frequently than their male counterparts, both in stable and acute clinical settings. Although traditionally considered a relatively infrequent and low-risk form of myocardial ischemia, its impact on clinical practice is undeniable, especially when it comes to infarction, where the prognosis is not as benign as previously assumed. Unfortunately, despite increasing awareness, there are still several questions left unanswered regarding diagnosis, risk stratification and treatment. The purpose of this review is to provide a state of the art and an update on current evidence available on gender differences in clinical characteristics, management and prognosis of ischemic heart disease with non-obstructive coronary arteries, both in the acute and stable clinical setting.

Morphology of Coronary Arteries in relation to Ischemic Heart Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Aurelio Leone
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Coronary Arteries ◽  
Coronary Circulation ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Ventricular Wall ◽  
The Right

Background: Background. The anatomical features of the coronary circulation show some interesting data which have been obtained by both in vivo and postmortem studies. Methods: This editorial describes the morphology and main alterations of coronary arteries, which supply blood flow to heart muscle, observed in the ischemic heart disease. Results : The great majority of myocardial muscle is under the control of the left coronary arteries: the left main coronary artery and its branches, the left anterior descending artery, and circumflex artery, which provide several arterial vessels particularly to the left anterior ventricular wall, interventricular septum and apex of the heart. Therefore, a large portion of the posterior left ventricular wall is supplied by left coronary circulation. The right coronary artery supplies blood flow to the posterior wall of the heart and the right atrium. Coronary anastomoses have been demonstrated into the myocardium showing that coronary arteries widely communicate among themselves. The main lesions of the coronary tree in subjects suffering from ischemic heart disease are related to coronary atherosclerosis. Conclusion: Morphology of coronary arteries is strongly influenced by ischemic pathology of the heart.

Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease

1996 ◽  
Vol 16 (8) ◽  
pp. 1000-1006 ◽  
Author(s):  
Joseph Galea ◽  
Johanna Armstrong ◽  
Patricia Gadsdon ◽  
Hazel Holden ◽  
Sheila E. Francis ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Coronary Arteries ◽  
Ischemic Heart ◽  
Interleukin 1Β

Evaluation of reconstructive coronary artery surgery in the treatment of ischemic heart disease

1969 ◽  
Vol 23 (1) ◽  
pp. 127-128
Author(s):  
J.A. McEachen ◽  
R.T. Smith ◽  
J.A. Cannon ◽  
P.G. Gaal ◽  
J.H. Davis ◽  
...  
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Coronary Artery Surgery

Abstract 342: Impact Of System And Physician Factors On The Diagnostic Yield Of Coronary Angiography In Stable Ischemic Heart Disease: A Population Based Study

2014 ◽  
Vol 7 (suppl_1) ◽  
Author(s):  
Harindra C Wijeysundera ◽  
Feng Qiu ◽  
Maria C Bennell ◽  
Madhu K Natarajan ◽  
Warren J Cantor ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Ischemic Heart Disease ◽  
Diagnostic Yield ◽  
Obstructive Coronary Artery Disease ◽  
Ischemic Heart ◽  
Patient Factors ◽  
Artery Disease

Background: Wide variation exists in the diagnostic yield of coronary angiography in stable ischemic heart disease (IHD). Previous work has primarily focused on patient factors for this variation. We sought to understand if system and physician factors, specifically hospital and physician type, as well as physician self-referral, have incremental impacts on the yield of coronary angiography, above and beyond that of patient factors alone. Methods: All patients who underwent a diagnostic coronary angiogram for possible stable IHD, at the 18 cardiac centers in Ontario, Canada were identified from October 1st, 2008 to September 30th, 2011. Obstructive coronary artery disease was defined as stenosis greater than 70% in the main coronary arteries or greater than 50% in the left main artery. Physicians were classified as either invasive or interventional. Hospitals were categorized into cath only, stand-alone PCI and full service centers. Multi-variable hierarchical logistic models were developed to identify system and physician level predictors of obstructive coronary artery disease, having adjusted for patient factors. Results: Our cohort consisted of 60,986 patients who underwent a diagnostic angiogram for possible stable IHD, of which 33,483 had obstructive coronary artery disease (54.9%), ranging from 41.0% to 70.2% across centers. Self-referral rates varied from 4.8% to 74.6%. Fewer self-referral patients (52.5%) had obstructive coronary artery disease compared to non-self-referral patients (56.5%), with an odds ratio (OR) of 0.89 (95% CI 0.85-0.93;p <0.001), after accounting for patient factors. Angiograms performed by interventional physicians had a higher likelihood of showing obstructive coronary artery disease (60.1% vs. 50.8%; OR 1.22; 95% CI 1.17-1.28; p<0.001). Fewer angiograms at cath only centers showed obstructive disease (45.0%) compared to full service centers (58.1%); this was of borderline significance (OR 0.59; 95% CI 0.34-1.00; p=0.05). Conclusion: Physician and system factors are important predictors of the diagnostic yield of coronary angiography in stable IHD, even after accounting for patient characteristics. Further study into the drivers of how these physician and system factors impact diagnostic yield is an important focus for quality improvement.

scholarly journals Pathomorphological characteristics of myocardial infarction complicated by rupture

2020 ◽  
Vol 12 (1) ◽  
pp. 63-70
Author(s):  
А. С. Повзун ◽  
A. S. Povzun
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Cardiac Rupture ◽  
In Vivo Diagnostics ◽  
Comorbid Diseases

The report presents the results of a pathoanatomical study of 81 cases of postinfarction cardiac rupture. The terms of development of cardiac rupture and comorbid background of patients are specified. Inconsistences of in vivo diagnostics of both ischemic heart disease and comorbid diseases, the results of autopsies were revealed.

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