Abstract 12642: Left Atrial Diameter as a Predictor of World Health Organization Group Two Pulmonary Hypertension Severity

Objective: Left atrial (LA) enlargement and dysfunction have poor prognostic significance in heart failure and coronary artery disease. However, the correlation between LA diameter and World Health Organization (WHO) Group 2 pulmonary hypertension (PH) severity has not been well studied. Hypothesis: We hypothesized that LA enlargement as a marker of LA remodeling in response to pressure and volume overload may contribute to higher pulmonary arterial pressures (PAP) in this population, independent of comorbidities and left ventricular ejection fraction (LVEF). Methods: After exclusion for severe left-sided valvular disease, 100 patients with isolated or mixed WHO Group 2 PH defined by right heart catheterization were studied in a cross-sectional retrospective analysis at a single institution. Linear LA anteroposterior diameter was obtained from the parasternal long-axis view on two dimensional TTE. LVEF, LV E/A Ratio, and LV Mass Index were measured according to ASE guidelines. LV E/A and LV Mass Index was recorded in 80 subjects and 79 subjects, respectively. Mean PAP was assessed on RHC. TTE and RHC were performed within one year of each other. Results: LA diameter was significantly associated with mean PAP after adjustment for age, sex, body-mass index, presence of coronary artery disease, hypertension, atrial fibrillation, and LVEF in multivariable linear regression analysis. In this multivariable model, a one centimeter increase in LA diameter predicted an average increase in mean PAP of 2.78 mmHg (95% CI 0.10, 5.46, p = 0.0423). In a subset of this population, LVEF, LV E/A Ratio, and LV Mass Index were not significant predictors of mean PAP. Reduction in cardiac index was noted with increasing LA diameter but this trend did not reach statistical significance. Conclusion: LA enlargement is significantly associated with increased mean PAP in patients with WHO Group 2 PH. LA enlargement may be a proxy for LA dysfunction and our data suggests that increased LA diameter may be a predictor of WHO Group 2 PH severity. Further studies of LA dimension, volume, and function are warranted to further our understanding of the left atrium’s relationship to PH.

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World Health Organization pulmonary hypertension group 2: pulmonary hypertension due to left heart disease

Pulmonary Circulation ◽

10.1201/9781315382753-49 ◽

2016 ◽

pp. 440-455

Keyword(s):

Pulmonary Hypertension ◽

Heart Disease ◽

World Health Organization ◽

World Health ◽

Left Heart ◽

Left Heart Disease ◽

Group 2 ◽

Health Organization

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P657 Deterioration of left ventricular performance in response to pulmonary hypertension, in patients with scleroderma versus patients with coronary artery disease

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.337 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

E Marton ◽

R Hodas ◽

C Blendea ◽

R Cucuruzac ◽

M Pirvu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Pulmonary Hypertension ◽

Systemic Sclerosis ◽

Coronary Artery ◽

Left Ventricular ◽

Left Ventricular Performance ◽

Ventricular Performance ◽

Group 2 ◽

Artery Disease ◽

Group 1

Abstract Funding Acknowledgements PlaqueImage Background The relationship between the degree of pulmonary hypertension (PH) and left ventricular performance in patients with systemic sclerosis is still a controversial issue in the literature. We aimed to conduct a comparative analysis of indexes characterizing left ventricular systolic and diastolic function, in two etiological types of pulmonary hypertension involving different pathophysiological mechanisms: PH caused by systemic sclerosis and PH caused by myocardial ischemia. Material and method We performed a prospective study on 83 patients (36 patients with documented PAH with a systolic pulmonary arterial pressure – sPAP of >35 mmHg and 47 subjects with normal sPAP), out of which group 1 – with systemic sclerosis (n = 48); group 2 – significant coronary artery disease - CAD (n = 35). Patients of each group were divided in two subgroups based on the diagnosis of PH: group 1A - subjects with scleroderma and associated PH (n = 20), group 1B - subjects with scleroderma without PH (n = 28), group 2A - ischemic patients with associated PH (n = 16) and subgroup 2B - patients with ischemic disease without PH (n = 19). Results Patients in group 1 presented a significantly higher number of female subjects (p = 0.001) and a higher mean age (p = 0.009) compared to group 2. Patients with associated PH presented a significantly lower left ventricular ejection fraction (LVEF) compared to those without PH within the ischemic group (p = 0.023). There was a significant inverse correlation between the sPAP and LVEF in ischemic patients (r=-0.52, p = 0.001) as well as for scleroderma patients without PH (r=-0.51, p = 0.04). Tissue Doppler analysis of the left ventricular function indicated a significant negative correlation between the septal E’ value versus the sPAP and lateral E’ value versus the sPAP (r=-0.49, p = 0.002; r=-0.43, p = 0,008). Conclusions Intrinsic myocardial damage plays an important role in left ventricular systolic function even in the absence of PAH. Scleroderma patients present a less pronounced deterioration of the LVEF in response to pulmonary hypertension, indicating that in this group, additional compensatory mechanisms could be involved in the complex response of myocardium to elevated pulmonary pressures.

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High-performance Cardiovascular Medicine: Artificial Intelligence for Coronary Artery Disease

10.21203/rs.3.rs-642228/v1 ◽

2021 ◽

Author(s):

H.M.K.K.M.B. Herath ◽

G.M.K.B. Karunasena ◽

H.D.N.S. Priyankara ◽

B.G.D.A. Madhusanka

Keyword(s):

Artificial Intelligence ◽

Cardiovascular Disease ◽

Coronary Artery Disease ◽

Coronary Artery ◽

High Performance ◽

Alcohol Intake ◽

World Health ◽

Essential Factor ◽

Artery Disease ◽

Health Organization

Abstract Cardiovascular disease (CVD) is identified as the leading cause of death globally, according to the World Health Organization (WHO). Approximately 17.9 million people are dying due to cardiovascular disease, which is an estimation of 31% of all deaths worldwide. CVDs are generally affecting the heart and blood vessels in the human body. Since healthcare is an essential factor for a country and its economy, researchers are looking for solutions to predict disease before getting into serious problems. This research introduces a method to development of an algorithm to predict coronary artery disease based on artificial intelligence. The algorithm was tested with 72 random subjects, which covered 11 attributes such as age, gender, height, weight, systolic and diastolic blood pressure, cholesterol, glucose, smoking, alcohol intake, and physical activities. According to the results, the prediction accuracy of the system was 81.62% at 0.879 precision.

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Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension

Hypertension ◽

10.1161/hypertensionaha.117.08824 ◽

2018 ◽

Vol 71 (1) ◽

pp. 34-55 ◽

Cited By ~ 9

Author(s):

Ping Yu Xiong ◽

Francois Potus ◽

Winnie Chan ◽

Stephen L. Archer

Keyword(s):

Pulmonary Hypertension ◽

World Health Organization ◽

Molecular Mechanisms ◽

World Health ◽

Group 2 ◽

Health Organization

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A Study of Prevalence and Predictors of Acute Ischemic CVA Patients Admitted to Manipal Teaching Hospital, Pokhara, Nepal

Eastern Green Neurosurgery ◽

10.3126/egn.v2i1.27462 ◽

2020 ◽

Vol 2 (1) ◽

pp. 42-46

Author(s):

Bishnu Jwarchan ◽

Nikunja Yogi ◽

Suman Adhikari ◽

Prabin Bhandari ◽

Subita Lalchan

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Statistical Significance ◽

World Health ◽

Systemic Hypertension ◽

Female Ratio ◽

History Of ◽

Artery Disease ◽

Health Organization

Background: According to the World Health Organization (WHO), 15 million people suffer stroke worldwide each year. Of these, 5 million die, and another 5 million are left permanently disabled. Materials and methods: A retrospective hospital based observational study was carried out in patients with ischemic CVA. Modified Ranking Scale (MRS) on the follow up on 30 days after discharge was obtained. MRS 0-2 was categorized and good outcome and MRS 3-6 was categorized as poor outcome. Results: Out of 56 patients studied 33.9 % were less than 60 years of age and 63.1% were greater than 60 years of age. Male to female ratio was 1.55. MCA territory infarct was the most common with the frequency of 76.8%. There was significant association of HTN, DM, coronary artery disease and other factors as well with the outcome of the patients. Conclusion: On regards to clinic-social demographic parameters there was statistical significance between the gender of the patient, history of systemic hypertension, history of diabetes mellitus and coronary artery disease and outcome of the patient in 30 days follow up.

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