Abstract MP32: Muscular Strength and Type 2 Diabetes Prevention

Introduction: There is little evidence on the effects of muscular strength, independent of cardiorespiratory fitness, on the development of type 2 diabetes. Hypothesis: We hypothesised that muscular strength, independent of cardiorespiratory fitness, has significant benefits in type 2 diabetes prevention. Methods: Participants were 5,578 men and women aged 18 to 100 years (mean age, 44) who received preventive medical examinations during 1980-2006 in the Aerobics Center Longitudinal Study. Participants were free of myocardial infarction, stroke, cancer, and diabetes at baseline. Total body muscular strength was quantified by combining 1 repetition maximum (1-RM) measures for leg and bench presses and categorized into three groups, lower (weak), middle, and upper (strong), based on the tertiles (thirds) of muscular strength. Cardiorespiratory fitness was measured by a maximal treadmill exercise test. Type 2 diabetes was defined as a fasting plasma glucose level of ≥126 mg/dl, a history of diabetes, or current insulin therapy. Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident type 2 diabetes by muscular strength after adjusting for baseline age, sex, examination year, body mass index (BMI), current smoking, heavy alcohol drinking, parental history of diabetes, hypertension, hypercholesterolemia, glucose level, and maximum treadmill test time. Results: During an average follow-up of 8 years, 270 (4.8%) individuals developed type 2 diabetes. Compared with the individuals in the lower third of muscular strength, individuals in the middle third had a 30% lower risk of developing type 2 diabetes (HR: 0.70, 95% CI: 0.51-0.95), whereas no significant benefit was found in individuals in the upper third (HR: 1.16, 95% CI: 0.86-1.57) after adjusting for potential confounders and cardiorespiratory fitness. We found similar results in men and women, young (<50 years) and old (≥50 years), and normal (BMI <25 kg/m 2 ) and overweight/obese (BMI ≥25 kg/m 2 ) individuals. In the combined analysis of muscular strength and cardiorespiratory fitness, we also found similar results that individuals in the middle third of muscular strength showed lower risks of developing type 2 diabetes in both low (lower 50%) and high (upper 50%) cardiorespiratory fitness, compared with individuals in the lower third of muscular strength and low cardiorespiratory fitness. Conclusions: We found that a moderate level of muscular strength, independent of cardiorespiratory fitness, is associated with a lower risk of developing type 2 diabetes. Additional studies on the dose-response relationship of muscular strength and incident type 2 diabetes are warranted.

Download Full-text

Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

Diabetes Care ◽

10.2337/dc19-2237 ◽

2020 ◽

Vol 43 (4) ◽

pp. 793-798 ◽

Cited By ~ 8

Author(s):

Sylvia H. Ley ◽

Jorge E. Chavarro ◽

Mengying Li ◽

Wei Bao ◽

Stefanie N. Hinkle ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Incident Type ◽

Incident Type 2 Diabetes ◽

History Of ◽

Lactation Duration

Download Full-text

Association of Oily and Nonoily Fish Consumption and Fish Oil Supplements With Incident Type 2 Diabetes: A Large Population-Based Prospective Study

10.2337/figshare.13342232.v1 ◽

2021 ◽

Author(s):

Guo-Chong Chen ◽

Rhonda Arthur ◽

Li-Qiang Qin ◽

Li-Hua Chen ◽

Zhendong Mei ◽

...

Keyword(s):

Type 2 Diabetes ◽

Fish Oil ◽

Fish Consumption ◽

Lower Risk ◽

Large Population ◽

Incident Type ◽

Incident Type 2 Diabetes ◽

Oily Fish ◽

Incident Cases

OBJECTIVE To evaluate associations of oily and non-oily fish consumption and fish oil supplements with incident type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We included<a> 392,287 middle-aged and older participants </a>(55.0% women) in the UK Biobank who were free of diabetes, major cardiovascular disease, and cancer, and had information on habitual intake of major food groups and use of fish oil supplements at baseline (<a>2006-2010</a>). Of these, <a>163,706</a> participated in 1-5 rounds of 24-h dietary recalls during 2009-2012. RESULTS During a median 10.1 years of follow-up, <a>7,262</a> incident cases of T2D were identified. As compared with participants who reported never consumption of oily fish, the multivariable-adjusted hazard ratios (95% CI) of T2D were 0.84 (0.78-0.91), 0.78 (0.72-0.85), and 0.78 (0.71-0.86) for those who reported <1 serving/week, weekly, and ≥2 servings/week of oily fish consumption, respectively (P-trend <0.001). Consumption of non-oily fish was not associated with risk of T2D (P-trend = 0.45). Participants who reported regular fish oil use at baseline had a 9% (95% CI: 4%-14%) lower risk of T2D as compared with non-users. Baseline regular users of fish oil who also reported fish oil use during at least one of the 24-h dietary recalls had an 18% (95% CI: 8%-27%) lower risk of T2D when compared with constant non-users. CONCLUSIONS Our findings suggest that consumption of oily fish, but not non-oily fish, was associated with a lower risk of T2D. Use of fish oil supplements, especially constant use over time, was also associated with a lower risk of T2D.

Download Full-text

Abstract MP05: Leisure-Time Running and Incident Type 2 Diabetes

Circulation ◽

10.1161/circ.131.suppl_1.mp05 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Duck-chul Lee ◽

Carl J. Lavie ◽

Timothy S. Church ◽

Xuemei Sui ◽

Steven N. Blair

Keyword(s):

Type 2 Diabetes ◽

Lower Risk ◽

Leisure Time ◽

Cox Regression ◽

Smoking Status ◽

Physical Activities ◽

Incident Type ◽

Incident Type 2 Diabetes

Introduction: There is still little evidence on the dose-response relation between leisure-time running and incident type 2 diabetes (T2D). Hypothesis: We examined the hypothesis that running reduces the risk of developing T2D. Methods: Participants were 19,347 adults aged 18 to 100 years (mean age, 44) who received an extensive preventive medical examination during 1974-2006 in the Aerobics Center Longitudinal Study. Participants were free of cardiovascular disease, cancer, and T2D at baseline. Running and other physical activities were assessed on the medical history questionnaire by self-reported leisure-time activities during the past 3 months. We defined T2D as fasting glucose ≥126 mg/dl, insulin use, or physician-diagnosis during follow-up medical examinations. Cox regression was used to quantify the association between running and T2D after adjusting for baseline age, sex, examination year, body mass index, smoking status, heavy alcohol drinking, abnormal electrocardiogram, hypertension, hypercholesterolemia, and levels of other physical activities. Results: During an average follow-up of 6.5 years, 1,015 adults developed T2D. Approximately 30% of adults participated in leisure-time running. Runners had a 29% lower risk of developing T2D compared with non-runners. The hazard ratios (95% confidence intervals) of T2D were 0.97 (0.74-1.27), 0.66 (0.49-0.89), 0.62 (0.45-0.85), 0.78 (0.58-1.03), and 0.57 (0.42-0.79) across quintiles (Q) of running time (minutes/week); 0.99 (0.76-1.30), 0.60 (0.44-0.82), 0.72 (0.55-0.94), 0.65 (0.47-0.90), and 0.63 (0.47-0.86) across Q of running distance (miles/week); 1.08 (0.83-1.40), 0.67 (0.50-0.90), 0.70 (0.53-0.93), 0.61 (0.45-0.83), and 0.53 (0.36-0.76) across Q of running frequency (times/week); 0.95 (0.73-1.24), 0.70 (0.52-0.94), 0.62 (0.45-0.84), 0.73 (0.55-0.97), and 0.58 (0.42-0.80) across Q of total amount of running (MET-minutes/week); and 0.95 (0.71-1.28), 0.76 (0.59-0.99), 0.59 (0.42-0.83), 0.66 (0.51-0.85), and 0.62 (0.43-0.90) across Q of running speed (mph), respectively, compared with no running after adjusting for confounders including levels of other physical activities. Conclusions: Participating in leisure-time running is associated with markedly lower risk of developing T2D in adults. Except for those in the very lowest Q for running doses, even relatively low running doses (starting with Q 2) were associated with marked reductions in T2D risk over time, supporting the prescription of running to reduce T2D.

Download Full-text

Utility of serum lipid ratios for predicting incident type 2 diabetes: the Isfahan Diabetes Prevention Study

Diabetes/Metabolism Research and Reviews ◽

10.1002/dmrr.2770 ◽

2016 ◽

Vol 32 (6) ◽

pp. 572-580 ◽

Cited By ~ 11

Author(s):

Mohsen Janghorbani ◽

Masoud Amini

Keyword(s):

Type 2 Diabetes ◽

Diabetes Prevention ◽

Serum Lipid ◽

Prevention Study ◽

Diabetes Prevention Study ◽

Incident Type ◽

Lipid Ratios ◽

Incident Type 2 Diabetes

Download Full-text

Greater Adherence to the Portfolio Diet Is Associated with Lower Incidence of Type 2 Diabetes in the Women's Health Initiative

Current Developments in Nutrition ◽

10.1093/cdn/nzab053_027 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 1034-1034

Author(s):

Andrea Glenn ◽

Kenneth Lo ◽

David Jenkins ◽

Beatrice Boucher ◽

Anthony Hanley ◽

...

Keyword(s):

Type 2 Diabetes ◽

Women's Health ◽

Postmenopausal Women ◽

Lower Risk ◽

Incident Type ◽

Health Initiative ◽

Incident Type 2 Diabetes ◽

Diet Score ◽

The Women’S Health Initiative

Abstract Objectives To assess the association of the plant-based cholesterol-lowering diet, the Portfolio Diet, with incident type 2 diabetes in women. Methods We followed 147,732 postmenopausal women initially free of diabetes in the Women's Health Initiative (WHI) Clinical Trials and Observational Study from 1993 through 2017. Adherence to the Portfolio Diet was assessed using an a priori diet index based on six food categories (high in plant protein [soy & pulses], nuts, viscous fiber, plant sterols and monounsaturated fat, and low in saturated fat) that were previously found to lower cardiovascular risk factors in the Portfolio Diet trials. We used Cox proportional-hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) of the association of adherence to a Portfolio Diet score with incident type 2 diabetes, adjusting for potential confounders (demographics, lifestyle behaviors, and medical history). The Portfolio Diet score was cumulatively assessed at baseline and year three using a validated food frequency questionnaire. Type 2 diabetes diagnosis was ascertained by self-reported medication use. Results There were 14,096 cases of incident type 2 diabetes over a mean follow-up of 14.3 years. In the fully adjusted models, adherence to the Portfolio Diet score was associated with a lower risk of incident type 2 diabetes (HR, 0.88, CIs, 0.83, 0.93; P for trend < 0.001), comparing the highest to lowest quartiles of adherence. Results remained similar across subgroup analyses (age, body mass index, family history of diabetes, and ethnicity) and several sensitivity analyses. Conclusions Among postmenopausal women, higher adherence to the Portfolio Diet was associated with lower incident type 2 diabetes. These findings are the first to show that the Portfolio Diet may be associated with a lower risk of type 2 diabetes and warrants further investigation. Funding Sources The WHI was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, and the U.S. Department of Health and Human Services. AJG was supported by the Banting & Best Diabetes Centre Tamarack Graduate Award in Diabetes Research, the Peterborough K.M. Hunter Charitable Foundation Graduate Award, and an Ontario Graduate Scholarship. JLS was funded by a Diabetes Canada Clinician Scientist Award.

Download Full-text

Association of Oily and Nonoily Fish Consumption and Fish Oil Supplements With Incident Type 2 Diabetes: A Large Population-Based Prospective Study

10.2337/figshare.13342232 ◽

2021 ◽

Author(s):

Guo-Chong Chen ◽

Rhonda Arthur ◽

Li-Qiang Qin ◽

Li-Hua Chen ◽

Zhendong Mei ◽

...

Keyword(s):

Type 2 Diabetes ◽

Fish Oil ◽

Fish Consumption ◽

Lower Risk ◽

Large Population ◽

Incident Type ◽

Incident Type 2 Diabetes ◽

Oily Fish ◽

Incident Cases

Download Full-text

Plasma Lipidomic Profiles in Relation to Incident Type 2 Diabetes among Women with a History of Gestational Diabetes Mellitus

Diabetes ◽

10.2337/db18-1539-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 1539-P

Author(s):

JUN LI ◽

LIMING LIANG ◽

FRANK HU ◽

CUILIN ZHANG ◽

DEIRDRE TOBIAS

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Incident Type ◽

Incident Type 2 Diabetes ◽

History Of

Download Full-text

Association of 20-Year Changes in Cardiorespiratory Fitness With Incident Type 2 Diabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) fitness study

Diabetes Care ◽

10.2337/dc08-1971 ◽

2009 ◽

Vol 32 (7) ◽

pp. 1284-1288 ◽

Cited By ~ 60

Author(s):

M. R. Carnethon ◽

B. Sternfeld ◽

P. J. Schreiner ◽

D. R. Jacobs ◽

C. E. Lewis ◽

...

Keyword(s):

Type 2 Diabetes ◽

Young Adults ◽

Coronary Artery ◽

Cardiorespiratory Fitness ◽

Incident Type ◽

Incident Type 2 Diabetes

Download Full-text

Perceived Barriers to Type 2 Diabetes Prevention for Low-Income Women With a History of Gestational Diabetes: A Qualitative Secondary Data Analysis

The Diabetes Educator ◽

10.1177/0145721720920255 ◽

2020 ◽

Vol 46 (3) ◽

pp. 271-278

Author(s):

Taniqua T. Ingol ◽

Jennifer Kue ◽

Elizabeth J. Conrey ◽

Reena Oza-Frank ◽

Mary Beth Weber ◽

...

Keyword(s):

Type 2 Diabetes ◽

Data Analysis ◽

Low Income ◽

Diabetes Prevention ◽

Secondary Data ◽

Perceived Barriers ◽

Type 2 Diabetes Prevention ◽

History Of ◽

Low Income Women

Purpose The purpose of this qualitative study was to examine perceived barriers to adoption of lifestyle changes for type 2 diabetes prevention among a diverse group of low-income women with a history of gestational diabetes mellitus (GDM). Methods A secondary data analysis of 10 semistructured focus group discussions was conducted. Participants were low-income African American, Hispanic, and Appalachian women ages 18 to 45 years who were diagnosed with GDM in the past 10 years. A qualitative content analysis was conducted to identify key themes that emerged within and between groups. Results Four key themes emerged on the role of knowledge, affordability, accessibility, and social support in type 2 diabetes prevention. Women discussed a lack of awareness of the benefits of breastfeeding and type 2 diabetes prevention, inaccessibility of resources in their local communities to help them engage in lifestyle change, and the desire for more culturally relevant education on healthful food options and proper portion sizes. Discussion Study findings suggests that to improve effectiveness of type 2 diabetes prevention efforts among low-income women with GDM history, health care providers and public health practitioners should avoid using “one-size-fits-all” approaches to lifestyle change and instead use tailored interventions that address the cultural and environmental factors that impact women’s ability to engage in recommended behavior change.

Download Full-text