scholarly journals Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase

2008 ◽  
Vol 103 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Annalisa Grasselli ◽  
Simona Nanni ◽  
Claudia Colussi ◽  
Aurora Aiello ◽  
Valentina Benvenuti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Estrogen Receptor Α ◽  
Nuclear Complex ◽  
Human Telomerase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 ◽  
Vol 103 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Zhong Chen ◽  
Ivan S. Yuhanna ◽  
Zoya Galcheva-Gargova ◽  
Richard H. Karas ◽  
Michael E. Mendelsohn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Estrogen Receptor Α ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

The role of nuclear endothelial nitric oxide synthase in the endothelial and prostate microenvironments

2011 ◽  
Vol 5 (2) ◽  
Author(s):  
Simona Nanni ◽  
Annalisa Grasselli ◽  
Valentina Benvenuti ◽  
Aurora Aiello ◽  
Valentina Pantisano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Target Genes ◽  
Nuclear Translocation ◽  
Androgen Independence ◽  
Human Telomerase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

AbstractThis review is based on novel observations from our laboratory on the nuclear translocation and functional role of endothelial nitric oxide synthase (eNOS) in endothelial and prostate cancer (PCa) epithelial cells. Nitric oxide (NO), the product of eNOS, is a free radical involved in the physiology and pathophysiology of living organisms and in a variety of biological processes including the maintenance of vascular homeostasis. Of relevance in this context is the role that estrogens play in the apoptotic process and the migration of endothelial cells through the regulation of target genes such as eNOS itself. It has been shown that both estrogen and NO signaling, mediated respectively by the estrogen receptors (ERs) and eNOS, can strongly counteract endothelial senescence through a common effector, the catalytic subunit of human telomerase. Therefore, this protein has been identified as a key molecule in the aging process which, intriguingly, is considered the only risk factor in the development of PCa and one of the major determinants of cardiovascular diseases. Indeed, in both these contexts we have defined a molecular mechanism involving activation of eNOS and hypoxia-inducible factors in association with ERβ that characterizes the most aggressive form of PCa or influences endothelial cell differentiation. Altogether these data led us to postulate that activation of eNOS is a crucial requirement for the delaying of endothelial senescence as well as for the acquisition of androgen-independence and for tumor progression in the prostate microenvironment.

scholarly journals Estrogen receptor a mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 ◽  
Vol 103 (9) ◽  
pp. 1363-1363 ◽  
Author(s):  
Zhong Chen ◽  
Ivan S. Yuhanna ◽  
Zoya Galcheva-Gargova ◽  
Richard H. Karas ◽  
Michael E. Mendelsohn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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