scholarly journals The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development

2020 ◽  
Vol 127 (4) ◽  
pp. 550-552
Author(s):  
Joseph B. Moore ◽  
Ghazal Sadri ◽  
Annalara G. Fischer ◽  
Tyler Weirick ◽  
Giuseppe Militello ◽  
...  
Keyword(s):  
Rna Editing ◽  
Growth And Development ◽  
Cardiac Growth ◽  
Editing Enzyme

scholarly journals The Zab Domain of the Human RNA Editing Enzyme ADAR1 Recognizes Z-DNA When Surrounded by B-DNA

2000 ◽  
Vol 275 (35) ◽  
pp. 26828-26833
Author(s):  
Yang-Gyun Kim ◽  
Ky Lowenhaupt ◽  
Stefan Maas ◽  
Alan Herbert ◽  
Thomas Schwartz ◽  
...  
Keyword(s):  
Rna Editing ◽  
Z Dna ◽  
Editing Enzyme

scholarly journals Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): structure–function relationships of RNA editing and dimerization

1999 ◽  
Vol 40 (4) ◽  
pp. 623-635 ◽  
Author(s):  
Ba-Bie Teng ◽  
Scott Ochsner ◽  
Qian Zhang ◽  
Kizhake V. Soman ◽  
Paul P. Lau ◽  
...  
Keyword(s):  
Structure Function ◽  
Rna Editing ◽  
Apolipoprotein B ◽  
Mutational Analysis ◽  
Mrna Editing ◽  
Editing Enzyme

scholarly journals A Left-Handed RNA Double Helix Bound by the Zα Domain of the RNA-Editing Enzyme ADAR1

Structure ◽  
2007 ◽  
Vol 15 (4) ◽  
pp. 395-404 ◽  
Author(s):  
Diana Placido ◽  
Bernard A. Brown ◽  
Ky Lowenhaupt ◽  
Alexander Rich ◽  
Alekos Athanasiadis
Keyword(s):  
Rna Editing ◽  
Double Helix ◽  
Left Handed ◽  
Editing Enzyme

scholarly journals ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway

2021 ◽  
Vol 5 (3) ◽  
pp. e202101191
Author(s):  
Xinfeng Guo ◽  
Silvia Liu ◽  
Rose Yan ◽  
Vy Nguyen ◽  
Mazen Zenati ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathway ◽  
Rna Editing ◽  
Sequencing Analysis ◽  
Newborn Mice ◽  
Interferon Stimulated Genes ◽  
Cell Functions ◽  
Multiple Organs ◽  
Elevated Expression ◽  
Editing Enzyme

The RNA-sensing signaling pathway has been well studied as an essential antiviral mechanism of innate immunity. However, its role in non-infected cells is yet to be thoroughly characterized. Here, we demonstrated that the RNA sensing signaling pathway also reacts to the endogenous cellular RNAs in endothelial cells (ECs), and this reaction is regulated by the RNA-editing enzyme ADAR1. Cellular RNA sequencing analysis showed that EC RNAs endure extensive RNA editing, especially in the RNA transcripts of short interspersed nuclear elements. The EC-specific deletion of ADAR1 dramatically reduced the editing level on short interspersed nuclear element RNAs, resulting in newborn death in mice with damage evident in multiple organs. Genome-wide gene expression analysis revealed a prominent innate immune activation with a dramatically elevated expression of interferon-stimulated genes. However, blocking the RNA sensing signaling pathway by deletion of the cellular RNA receptor MDA-5 prevented interferon-stimulated gene expression and rescued the newborn mice from death. This evidence demonstrated that the RNA-editing/RNA-sensing signaling pathway dramatically modulates EC function, representing a novel molecular mechanism for the regulation of EC functions.

PC.01.7 AN ESSENTIAL ROLE OF RNA EDITING ENZYME ADAR1 IN COELIAC DISEASE MUCOSA

2021 ◽  
Vol 53 ◽  
pp. S90
Author(s):  
M.T. Segreto ◽  
D. Di Fusco ◽  
S. Sessa ◽  
G. Di Maggio ◽  
C. Maresca ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Rna Editing ◽  
Essential Role ◽  
Editing Enzyme

Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis

2010 ◽  
Vol 24 (10) ◽  
pp. 3720-3732 ◽  
Author(s):  
Liu Yang ◽  
Liyun Zhao ◽  
Zhenji Gan ◽  
Zixuan He ◽  
Jingyue Xu ◽  
...  
Keyword(s):  
Rna Editing ◽  
Regulated Exocytosis ◽  
Editing Enzyme

scholarly journals Molecular Modelling of the Biosynthesis of the Rna-Editing Enzyme Apobec-1, Responsible for Generating the Alternative forms of Apolipoprotein B

1999 ◽  
Vol 84 (4) ◽  
pp. 791-800 ◽  
Author(s):  
James Scott ◽  
Naveenan Navaratnam ◽  
Charles Carter
Keyword(s):  
Rna Editing ◽  
Molecular Modelling ◽  
Apolipoprotein B ◽  
Editing Enzyme

scholarly journals TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins

Cell ◽  
2016 ◽  
Vol 165 (3) ◽  
pp. 742-753 ◽  
Author(s):  
Aoife C. McMahon ◽  
Reazur Rahman ◽  
Hua Jin ◽  
James L. Shen ◽  
Allegra Fieldsend ◽  
...  
Keyword(s):  
Rna Editing ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Editing Enzyme
Sign in / Sign up

Export Citation Format

Share Document