scholarly journals Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates

Circulation ◽  
2016 ◽  
Vol 133 (12) ◽  
pp. 1181-1188 ◽  
Author(s):  
Iftikhar J. Kullo ◽  
Hayan Jouni ◽  
Erin E. Austin ◽  
Sherry-Ann Brown ◽  
Teresa M. Kruisselbrink ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Risk Score ◽  
Coronary Heart Disease Risk ◽  
Genetic Risk ◽  
Disease Risk ◽  
Genetic Risk Score ◽  
Risk Estimates ◽  
Heart Disease Risk

Effect of soluble-viscous dietary fibre on coronary heart disease risk score across 3 population health categories: data from randomized, double-blind, placebo-controlled trials

2020 ◽  
Vol 45 (7) ◽  
pp. 801-804
Author(s):  
Vladimir Vuksan ◽  
John L. Sievenpiper ◽  
Elena Jovanovski ◽  
Alexandra L. Jenkins ◽  
Allison Komishon ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Risk Score ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Blood Cholesterol ◽  
Double Blind ◽  
Framingham Risk ◽  
Heart Disease Risk

We applied the Framingham risk equation in healthy, metabolic syndrome, and diabetes populations, following treatment with viscous fibre from konjac-based blend (KBB). KBB yielded reduction in estimated risk score by 16% (1.04 ± 0.03 vs. 0.87 ± 0.04, p < 0.01) in type 2 diabetes, 24% (1.08 ± 0.01 vs. 0.82 ± 0.02, p < 0.01) in metabolic syndrome, and 25% (1.09 ± 0.05 vs. 0.82 ± 0.06, p < 0.01) in healthy individuals. Drivers for decreased risk were improvements in blood cholesterol and systolic blood pressure. The composite coronary heart disease risk across populations was reduced 22% (p < 0.01). Novelty Viscous fibre from konjac-xanthan reduced 10-year relative coronary heart disease using Framingham Risk Score across the glycemic status spectrum.

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