scholarly journals Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading

Circulation ◽  
2017 ◽  
Vol 135 (17) ◽  
pp. 1632-1645 ◽  
Author(s):  
Thomas Seidel ◽  
Sutip Navankasattusas ◽  
Azmi Ahmad ◽  
Nikolaos A. Diakos ◽  
Weining David Xu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Functional Recovery ◽  
Human Heart ◽  
Human Heart Failure ◽  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Mechanical Unloading ◽  
Tubular System

scholarly journals Transmural Heterogeneity and Remodeling of Ventricular Excitation-Contraction Coupling in Human Heart Failure

Circulation ◽  
2011 ◽  
Vol 123 (17) ◽  
pp. 1881-1890 ◽  
Author(s):  
Qing Lou ◽  
Vadim V. Fedorov ◽  
Alexey V. Glukhov ◽  
Nader Moazami ◽  
Vladimir G. Fast ◽  
...  
Keyword(s):  
Heart Failure ◽  
Human Heart ◽  
Human Heart Failure ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Transmural Heterogeneity

Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure

2016 ◽  
Vol 172 ◽  
pp. 30-44 ◽  
Author(s):  
Siva S.V.P. Sakamuri ◽  
Abhijit Takawale ◽  
Ratnadeep Basu ◽  
Paul W.M. Fedak ◽  
Darren Freed ◽  
...  
Keyword(s):  
Heart Failure ◽  
Extracellular Matrix ◽  
Human Heart ◽  
Differential Impact ◽  
Human Heart Failure ◽  
Nonstructural Components ◽  
Mechanical Unloading

scholarly journals Excitation-contraction coupling: role of K-activation within the transverse tubular system.

1983 ◽  
Vol 80 (4) ◽  
pp. 988-992
Author(s):  
J. P. Reuben ◽  
G. M. Katz ◽  
P. W. Brandt ◽  
G. Suarez-Kurtz ◽  
M. S. Dekin
Keyword(s):  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Tubular System

scholarly journals Mechanical Unloading Promotes Myocardial Energy Recovery in Human Heart Failure

2014 ◽  
Vol 7 (3) ◽  
pp. 266-276 ◽  
Author(s):  
Anisha A. Gupte ◽  
Dale J. Hamilton ◽  
Andrea M. Cordero-Reyes ◽  
Keith A. Youker ◽  
Zheng Yin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Energy Recovery ◽  
Human Heart ◽  
Human Heart Failure ◽  
Mechanical Unloading

scholarly journals Evidence for Anion-Permselective Membrane in Crayfish Muscle Fibers and Its Possible Role in Excitation-Contraction Coupling

1963 ◽  
Vol 47 (1) ◽  
pp. 189-214 ◽  
Author(s):  
Lucien Girardier ◽  
John P. Reuben ◽  
Philip W. Brandt ◽  
Harry Grundfest
Keyword(s):  
Muscle Fibers ◽  
Current Loop ◽  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Permselective Membrane ◽  
Tubular System ◽  
Inward Currents ◽  
A Current ◽  
T System

Under certain conditions only, isolated crayfish skeletal muscle fibers change in appearance, becoming grainy, darkening, and seemingly losing their striations. These changes result from development of large vesicles on both sides of the Z-line. The longitudinal sarcoplasmic reticulum remains unaffected. The vesicles are due to swelling of a transverse tubular system (TTS) which is presumably homologous with the T-system tubules of other muscle fibers. The vesiculations occur during efflux of water or on reducing external K or Cl, but only when KCl can leave the fiber. They never result from osmotic, ionic, or electrical changes when KCl cannot leave. Inward currents, applied through a KCl-filled intracellular cathode, also cause the vesiculations. These are not produced when the cathode is filled with K-propionate, nor by outward or longitudinal currents. Thus the transverse tubules swell only when Cl leaves the cell. Accordingly, their membrane is largely or exclusively anion-permselective. These findings also indicate that the TTS forms part of a current loop, connecting with the exterior of the fiber probably through radial tubules (RT) possessing membrane of low conductivity. Thus, part of the current flowing inward across the sarcolemma during activity can return to the exterior through the membrane of the TTS. The structure and properties of the latter offer the possibility for an efficient electrical mechanism to initiate excitation-contraction coupling.

scholarly journals Action Potentials, Afterpotentials, and Excitation-Contraction Coupling in Frog Sartorius Fibers without Transverse Tubules

1969 ◽  
Vol 53 (3) ◽  
pp. 298-310 ◽  
Author(s):  
Peter W. Gage ◽  
Robert S. Eisenberg
Keyword(s):  
Membrane Potential ◽  
Short Duration ◽  
Action Potentials ◽  
Sartorius Muscle ◽  
Transverse Tubules ◽  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Tubular System ◽  
Frog Sartorius

In frog sartorius muscle fibers in which the transverse tubular system has been disrupted by treatment with glycerol, action potentials which are unaccompanied by twitches can be recorded. These action potentials appear to be the same as those recorded in normal fibers except that the early afterpotential usually consists of a small hyperpolarization of short duration. After a train of action potentials no late afterpotential is seen even when the membrane potential is changed from the resting level. In fibers without transverse tubules hyperpolarizing currents do not produce a creep in potential. The interruption of excitation-contraction coupling, the changes in the afterpotentials, and the disappearance of creep are all attributed to the lack of a transverse tubular system.

Sign in / Sign up

Export Citation Format

Share Document