scholarly journals Local Association Between Endothelial Dysfunction and Intimal Hyperplasia: Relevance in Peripheral Artery Disease

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Yvonne Heinen ◽  
Emilia Stegemann ◽  
Roberto Sansone ◽  
Kolja Benedens ◽  
Rabea Wagstaff ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Peripheral Artery Disease ◽  
Intimal Hyperplasia ◽  
Peripheral Artery ◽  
Local Association ◽  
Artery Disease

scholarly journals Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease

Antioxidants ◽  
2018 ◽  
Vol 7 (10) ◽  
pp. 145 ◽  
Author(s):  
Ahmed Ismaeel ◽  
Robert Brumberg ◽  
Jeffrey Kirk ◽  
Evlampia Papoutsi ◽  
Patrick Farmer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Arterial Stiffness ◽  
Peripheral Artery Disease ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Current Evidence ◽  
Peripheral Artery ◽  
Potential Therapeutic Role ◽  
Artery Disease ◽  
And Oxidative Stress

Peripheral artery disease (PAD) is an atherosclerotic disease characterized by a narrowing of the arteries in the lower extremities. Disease manifestations are the result of more than just reduced blood flow, and include endothelial dysfunction, arterial stiffness, and inflammation. Growing evidence suggests that these factors lead to functional impairment and decline in PAD patients. Oxidative stress also plays an important role in the disease, and a growing amount of data suggest a link between arterial dysfunction and oxidative stress. In this review, we present the current evidence for the involvement of endothelial dysfunction, arterial stiffness, and inflammation in the pathophysiology of PAD. We also discuss the links between these factors and oxidative stress, with a focus on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2)-derived reactive oxygen species (ROS) and decreased nitric oxide (NO) bioavailability. Finally, the potential therapeutic role of NOX2 antioxidants for improving arterial function and functional status in PAD patients is explored.

scholarly journals PS150. Determinants of Endothelial Dysfunction in Peripheral Artery Disease: Importance of Kidney Disease

2014 ◽  
Vol 59 (6) ◽  
pp. 70S ◽  
Author(s):  
Karen C. Chong ◽  
Christopher D. Owens ◽  
Hugh F. Alley ◽  
Michael S. Conte ◽  
Warren J. Gasper ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Kidney Disease ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Endothelial dysfunction in patients with hypertension and peripheral artery disease

2016 ◽  
Vol 97 (5) ◽  
pp. 691-695 ◽  
Author(s):  
M N Denisenko ◽  
V V Genkel ◽  
I I Shaposhnik
Keyword(s):  
Essential Hypertension ◽  
Endothelial Dysfunction ◽  
Peripheral Artery Disease ◽  
Brachial Artery ◽  
Lower Limb ◽  
Carotid Arteries ◽  
Peripheral Artery ◽  
Brachial Artery Diameter ◽  
Atherosclerotic Lesions ◽  
Artery Disease

Aim. To assess endothelial function in patients with hypertension and peripheral artery disease.Methods. The study included 100 patients with an established diagnosis of essential hypertension. Ultrasonic duplex scanning of brachiocephalic arteries and lower limb arteries was performed. The functional state of the endothelium was evaluated using postocclusive reactive hyperemia test by D.S. Celermajer.Results. Atherosclerotic plaques in the carotid arteries were found in 71% of patients, in the lower limb arteries - in 60%. The combined affection of both vascular beds was diagnosed in 51% of patients. Endothelial dysfunction was found in 64% of patients. In patients with carotid arterial system atherosclerosis, brachial artery dilation response was 6.1%, while in those with intact carotid arteries - 4.7% (p=0.041). The value of the brachial artery dilation response in patients with atherosclerotic lesions of lower extremities arteries was 5.9%. In the subgroup of patients with intact lower limbs arteries, the increase in brachial artery diameter was 9.60% an average (p=0.04). Among 51 people with affection of both vascular systems the brachial artery diameter increase was 5.4%, while in comparison, in the subgroup consisting of 49 patients without combined carotid and lower limb arteries lesions, - 9.9% (p=0.003). According to the results of the correlation analysis, the relation between endothelial dysfunction and the maximum percentage of stenosis of the carotid arteries and lower limb arteries at the level of tibial segment was revealed.Conclusion. In patients with hypertension and peripheral artery disease, decrease in dilation response in endothelium-dependent vasodilation test was registered regardless of the localization of atherosclerotic lesions; endothelial dysfunction in essential hypertension was associated with the highest percentage of stenosis of the carotid arteries and lower limb arteries at the level of tibial segment.

scholarly journals The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 590
Author(s):  
Ahmed Ismaeel ◽  
Evlampia Papoutsi ◽  
Dimitrios Miserlis ◽  
Ramon Lavado ◽  
Gleb Haynatzki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Peripheral Artery Disease ◽  
Oxide System ◽  
Protein Carbonyls ◽  
Nitric Oxides ◽  
Peripheral Artery ◽  
No Bioavailability ◽  
Artery Disease

Peripheral artery disease (PAD) pathophysiology extends beyond hemodynamics to include other operating mechanisms, including endothelial dysfunction. Oxidative stress may be linked to endothelial dysfunction by reducing nitric oxide (NO) bioavailability. We aimed to investigate whether the NO system and its regulators are altered in the setting of PAD and to assess the relationship between NO bioavailability and oxidative stress. Sera from 35 patients with intermittent claudication (IC), 26 patients with critical limb ischemia (CLI), and 35 non-PAD controls were analyzed to determine levels of tetrahydrobiopterin (BH4), dihydrobiopterin (BH2), nitrate/nitrite (nitric oxides, or NOx), arginine, citrulline, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and the oxidative stress markers 8-Oxo-2′-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), advanced glycation end products (AGEs), and protein carbonyls. NOx was significantly lower in IC and CLI patients compared to controls in association with elevated oxidative stress, with the greatest NOx reductions observed in CLI. Compared with controls, IC and CLI patients had reduced BH4, elevated BH2, and a reduced BH4/BH2 ratio. SDMA, the arginine/SDMA ratio, and the arginine/ADMA ratio were significantly higher in CLI patients. The NO system and its regulators are significantly compromised in PAD. This dysregulation appears to be driven by increased oxidative stress and worsens as the disease progresses from claudication to CLI.

Associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm – a grin without a cat!

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Peripheral Artery ◽  
Epidemiological Evidence ◽  
Abdominal Aortic ◽  
Artery Disease ◽  
Meta Analyses

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.

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