Abstract W P72: Quantitative Analysis of The Blood Flow Reduction In Brain Aneurysms Treated By Flow Diverter Stents

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Aichi Chien ◽  
Qianyi Yu ◽  
Dominique Zosso
Keyword(s):  
Blood Flow ◽  
Image Quality ◽  
Contrast Agent ◽  
Flow Diverter ◽  
Input Image ◽  
Mixture Ratio ◽  
Flow Reduction ◽  
Blood Flow Reduction ◽  
Brain Aneurysms ◽  
The Impact

Purpose: This pilot study demonstrates an approach to quantitatively analyze the blood flow reduction in intracranial aneurysms treated by flow diverter stents (FDS). Method: 2D digital subtraction angiography (DSA) images from 13 aneurysm patients were analyzed with the model. Each patient had 2 sets of consecutive DSA images (3 frames/sec and 6 ml/sec contrast injection rate) acquired before and after FDS treatment. The mean age of the patients was 55, ranging from 5 to 86 years old. The model extracted contrast-agent concentration profiles from each DSA image’s ROIs (inlet, aneurysm, and outlet regions) to calculate the blood contrast-agent mixture ratio, which reflected the percentage of blood not being diverted into aneurysm. To evaluate image quality, signal-to-noise ratio (SNR) and the relative-standard-deviation (RSD, a measure of results’ dispersion), 10 additional sets of ROIs were randomly generated for each DSA image set and also analyzed. Result: The model showed that the 13 patients’ blood contrast-agent mixture ratios increased by 48% on average after FDS treatment. This demonstrates that the blood flow into the aneurysms was significantly ( p < 0.0006) reduced after FDS treatment. The study also found an inverse relationship between the input image SNR and the RSD of output results. The correlation coefficient of image SNR and mixture ratio RSD was -0.6257 for pre-FDS treatment image sets, and -0.4512 for post-FDS treatment image sets. To control the dispersion of results for future studies, images with SNR > 11.2487 were recommended in order to yield results with RSD < 0.15 for 95% C.I. Conclusion: Blood flow reduction due to FDS treatment in patients with brain aneurysms can be measured directly by 2D DSA. This study also verified the impact of input image quality on flow reduction estimation.

scholarly journals Famotidine prevents canine gastric blood flow reduction by NSAIDs

2005 ◽  
Vol 21 (s2) ◽  
pp. 55-59 ◽  
Author(s):  
J. Hata ◽  
T. Kamada ◽  
N. Manabe ◽  
H. Kusunoki ◽  
D. Kamino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gastric Blood Flow ◽  
Flow Reduction ◽  
Blood Flow Reduction

scholarly journals Two-stage Operation for Stanford Type B Acute Aortic Dissection with Renal Blood Flow Reduction

2018 ◽  
Vol 79 (4) ◽  
pp. 708-712
Author(s):  
Yusuke SHIMIZU ◽  
Susumu ISHIKAWA ◽  
Hideki MISHIMA ◽  
Yuki MATSUNAGA ◽  
Yuki NISHIHARA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Aortic Dissection ◽  
Renal Blood Flow ◽  
Acute Aortic Dissection ◽  
Type B ◽  
Two Stage ◽  
Flow Reduction ◽  
Blood Flow Reduction ◽  
Stanford Type B

Hepatosplanchnic Vasoregulation and Oxygen Consumption During Selective Aortic Blood Flow Reduction and Reperfusion

2011 ◽  
Vol 171 (2) ◽  
pp. 532-539 ◽  
Author(s):  
Ruy J. Cruz ◽  
Alejandra G. Garrido ◽  
Décio de Natale Caly ◽  
Mauricio Rocha-e-Silva
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Aortic Blood Flow ◽  
Flow Reduction ◽  
Aortic Blood ◽  
Blood Flow Reduction

Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis

Neurology ◽  
2002 ◽  
Vol 59 (3) ◽  
pp. 321-326 ◽  
Author(s):  
M. O'Sullivan ◽  
D. J. Lythgoe ◽  
A. C. Pereira ◽  
P. E. Summers ◽  
J. M. Jarosz ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Reduction ◽  
Blood Flow Reduction

The Morphology of Somatosensory Evoked Potentials During Middle Cerebral Artery Aneurysm Clipping (MoSAC): A Pilot Study

2019 ◽  
Vol 51 (2) ◽  
pp. 130-136
Author(s):  
Franca Tecchio ◽  
Federico Cecconi ◽  
Elisabetta Colamartino ◽  
Matteo Padalino ◽  
Luca Valci ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pilot Study ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Small Sample ◽  
Flow Reduction ◽  
Aneurysm Clipping ◽  
Blood Flow Reduction ◽  
Mca Aneurysm ◽  
Sep Monitoring

Somatosensory evoked potential (SEP) monitoring is a standard tool during clipping of aneurysms of the middle cerebral artery (MCA), and the parameter used to detect a state of cortical ischemia is amplitude. We think that the sensitivity of SEP can however be improved by using other parameters. Our study moves in this direction via SEP morphology. In this pilot preliminary study, involving a small sample without postoperative neurological deficit, we aimed at investigating the value of SEP morphology (in the 15- to 35-ms time frame), in comparison with SEP amplitude (N20 peak-to-peak), as a measure of sensitivity to blood flow reduction. The changes in the SEP morphology of 16 patients undergoing clipping of an unruptured MCA aneurysm was studied. We applied the Morph-Fréchet index for each recorded SEP (at 30-second intervals), quantifying the pattern shape change with regard to the average SEP recorded after dura opening (baseline). We also compared 3 measurements of the SEP morphology, without and with GARCH-derived filter. Filtered Morph-Fréchet never exceeded the individual’s “normality” range in baseline but did so in 81% of the risk phase on average across the 16 subjects, which is more than that for amplitude (36%, P = .002). This pilot study indicates that a measurement derived from the networking nature of the brain was sensitive to blood flow reduction. The SEP morphology approach promises to improve SEP monitoring sensitivity during clipping of unruptured MCA aneurysms. New and Noteworthy. The higher sensitivity to blood flow reduction of SEP morphology than amplitude promises to improve the effectiveness of intraoperative monitoring during MCA aneurysm clipping procedures.

Effect of prolonged uterine blood flow reduction on fetal growth in sheep

1996 ◽  
Vol 270 (1) ◽  
pp. R246-R253 ◽  
Author(s):  
D. W. Boyle ◽  
S. Lecklitner ◽  
E. A. Liechty
Keyword(s):  
Growth Rate ◽  
Blood Flow ◽  
Fetal Growth ◽  
Linear Growth ◽  
Arterial Oxygen ◽  
Linear Growth Rate ◽  
Uterine Blood Flow ◽  
Arterial Oxygen Content ◽  
Flow Reduction ◽  
Blood Flow Reduction

The purpose of the present investigation was to study the effect of 7 days of uterine blood flow reduction on fetal growth. Reduction in uterine blood flow was accomplished by external occlusion of the terminal aorta in 20 pregnant sheep. Linear growth was monitored daily by means of a crown-rump length measuring device. The deliveries of oxygen, glucose, and lactate to the fetus, as well as their uptakes by the fetus, were determined before and after 7 days of uterine blood flow reduction and correlated with rates of fetal growth. Identical studies were conducted in nine control animals. Uterine blood flow reduction resulted in a significant decrease in fetal oxygen delivery and fetal arterial oxygen content. Linear growth rate decreased by 38% in the occluded animals during hypoxemia. In addition, there was a 20% reduction in daily weight gain in occluded animals compared with controls. There were no differences in the uptakes of oxygen, glucose, and lactate by the fetus. Positive correlations were found between linear growth rate and fetal arterial oxygen content (r2 = 0.25, P = 0.0001) and between linear growth rate and fetal oxygen delivery (r2 = 0.21, P = 0.0006). The correlations between linear growth rate and fetal oxygenation provide strong evidence of the central role of oxygen in the regulation of fetal growth.

Sign in / Sign up

Export Citation Format

Share Document