Abstract WP398: Timing of Starting Doacs and Short- and Long-Term Clinical Outcomes for Acute Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation: The Samurai-nvaf Study

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Tadataka Mizoguchi ◽  
Masahito Takagi ◽  
Shoichiro Sato ◽  
Hiroshi Yamagami ◽  
Toshihiro Ide ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Outcomes ◽  
Stroke Patients ◽  
Nonvalvular Atrial Fibrillation ◽  
Short And Long Term

Abstract 176: Long Term Mortality in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation According to Location and Burden of Cerebral Microbleeds

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Tae-Jin Song ◽  
Jinkwon Kim ◽  
Dongbeom Song ◽  
Yong-Jae Kim ◽  
Hyo Suk Nam ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Hemorrhagic Stroke ◽  
Independent Predictor ◽  
Stroke Patients ◽  
Risk Of Death ◽  
Long Term Mortality

Background: Cerebral microbleeds (CMBs) were predictive of mortality in elderly and considered as a putative marker for risk of intracranial hemorrhage. Stroke patients with non valvular atrial fibrillation (NVAF) require anticoagulation, which increases the risk of hemorrhages. We investigated association of CMBs with the long term mortality in acute ischemic stroke patients with NVAF. Methods: During 6 years , consecutive ischemic stroke patients who had NVAF and who had undergone brain MRI with a gradient-recalled echo sequence were enrolled. Long-term mortality and causes of death were identified using data from Korean National Statistical Office. Survival analysis was performed whether the presence, number and location of CMBs were related with all causes, cardiovascular, and cerebrovascular mortality during follow-up. Results: Total 506 patients were enrolled during the study period and were followed up for median 2.5 years. CMBs were found in 30.8% of patients (156/506). Oral anticoagulation with warfarin was prescribed at discharge in 477 (82.7%) patients. During follow up, 177 (35%) patients died and cerebrovascular death was noted in 93 patients (81 ischemic stroke and 12 hemorrhagic stroke). After adjusting age, sex and significant variables in univariate analysis (p<0.1), multiple CMBs (≥5) were the independent predictor for all-cause, cardiovascular and ischemic stroke mortalities. The strictly lobar CMBs were associated with hemorrhagic stroke mortality in multivariate Cox regression analysis (HR 4.776, p=0.032) (Figure 1). Conclusions: Multiple CMBs were the independent predictor for the long term mortality in stroke patients with NVAF. Among them, patients with strictly lobar CMBs had a high risk of death due to hemorrhagic stroke. Our findings suggest that detection of CMBs in stroke patients with NVAF are of clinical relevance for predicting long term outcome and that particular concern is necessary in those with strictly lobar CMBs for their increased risk of death due to hemorrhagic stroke. Figure 1.

scholarly journals Pneumonia in acute ischemic stroke patients requiring invasive ventilation: Impact on short and long-term outcomes

2019 ◽  
Vol 79 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Etienne de Montmollin ◽  
Stephane Ruckly ◽  
Carole Schwebel ◽  
Francois Philippart ◽  
Christophe Adrie ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Invasive Ventilation ◽  
Stroke Patients ◽  
Long Term Outcomes ◽  
Short And Long Term

Abstract 115: Blood Pressure Trajectories In The Acute Phase And Major Clinical Outcomes Among Patients With Ischemic Stroke

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Changwei Li ◽  
Yonghong Zhang ◽  
Jing Chen ◽  
Tan Xu ◽  
Dali Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Outcomes ◽  
Acute Phase ◽  
Latent Class ◽  
Latent Class Models ◽  
Odds Ratios ◽  
Short And Long Term

We studied the relationship of blood pressure (BP) trajectories during the first seven days after symptom onset with short- and long-term major clinical outcomes among patients with acute ischemic stroke. A total of 4,036 patients with acute ischemic stroke and elevated systolic BP from the CATIS trial were included in this analysis. Three BPs were measured every 2 hours for the first 24 hours, every 4 hours during the second and third days, and every 8 hours thereafter for the remainder of the seven days. Latent class models were used to identify subgroups that share a similar underlying trajectory in BP in the acute phase. Five systolic BP trajectories of high, high-to-moderate low, moderate high, moderate low, and low were identified. Compared to the high trajectory, multiple-adjusted odds ratios (95% CI) of death and major disability at 3 months for high-to-moderate low, moderate high, moderate low, and low trajectories were 0.61 (0.44 to 0.86), 0.63 (0.48 to 0.84), 0.49 (0.37 to 0.65), and 0.42 (0.30 to 0.59), respectively (overall p<0.0001). Likewise, the corresponding multiple-adjusted odds ratios at 2 years were 0.64 (0.46 to 0.90), 0.78 (0.59 to 1.04), 0.49 (0.37 to 0.66), and 0.49 (0.34 to 0.69), respectively (overall p<0.0001). These data indicate that individuals with a consistently high systolic BP during the acute phase of ischemic stroke had the highest risk of short- and long-term death and major disability. In addition, moderate systolic BP reduction to below 140 mmHg from higher levels lowers risk of short- and long-term death and major disability.

scholarly journals Use of Warfarin at Discharge Among Acute Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation in China

Stroke ◽  
2016 ◽  
Vol 47 (2) ◽  
pp. 464-470 ◽  
Author(s):  
Xiaomeng Yang ◽  
Zixiao Li ◽  
Xingquan Zhao ◽  
Chunjuan Wang ◽  
Liping Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Stroke Patients ◽  
Nonvalvular Atrial Fibrillation
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