scholarly journals Acute Stroke Imaging Research Roadmap IV: Imaging Selection and Outcomes in Acute Stroke Clinical Trials and Practice

Stroke ◽  
2021 ◽  
Author(s):  
Bruce C.V. Campbell ◽  
Maarten G. Lansberg ◽  
Joseph P. Broderick ◽  
Colin P. Derdeyn ◽  
Pooja Khatri ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Acute Stroke ◽  
Time Window ◽  
Stroke Treatment ◽  
Consensus Recommendations ◽  
Stroke Imaging ◽  
The Us ◽  
Imaging Research ◽  
Optimal Imaging ◽  
Acute Stroke Imaging

Background and Purpose: The Stroke Treatment Academic Industry Roundtable (STAIR) sponsored an imaging session and workshop during the Stroke Treatment Academic Industry Roundtable XI via webinar on October 1 to 2, 2020, to develop consensus recommendations, particularly regarding optimal imaging at primary stroke centers. Methods: This forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke, industry representatives, and members of the US Food and Drug Administration to discuss imaging priorities in the light of developments in reperfusion therapies, particularly in an extended time window, and reinvigorated interest in brain cytoprotection trials. Results: The imaging session summarized and compared the imaging components of recent acute stroke trials and debated the optimal imaging strategy at primary stroke centers. The imaging workshop developed consensus recommendations for optimizing the acquisition, analysis, and interpretation of computed tomography and magnetic resonance acute stroke imaging, and also recommendations on imaging strategies for primary stroke centers. Conclusions: Recent positive acute stroke clinical trials have extended the treatment window for reperfusion therapies using imaging selection. Achieving rapid and high-quality stroke imaging is therefore critical at both primary and comprehensive stroke centers. Recommendations for enhancing stroke imaging research are provided.

scholarly journals Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials

Stroke ◽  
2016 ◽  
Vol 47 (5) ◽  
pp. 1389-1398 ◽  
Author(s):  
Steven J. Warach ◽  
Marie Luby ◽  
Gregory W. Albers ◽  
Roland Bammer ◽  
Andrew Bivard ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Acute Stroke ◽  
Stroke Imaging ◽  
Imaging Research ◽  
Acute Stroke Imaging

scholarly journals Acute Stroke Imaging Research Roadmap

Stroke ◽  
2008 ◽  
Vol 39 (5) ◽  
pp. 1621-1628 ◽  
Author(s):  
Max Wintermark ◽  
Gregory W. Albers ◽  
Andrei V. Alexandrov ◽  
Jeffry R. Alger ◽  
Roland Bammer ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Stroke Imaging ◽  
Imaging Research ◽  
Acute Stroke Imaging

scholarly journals A Multicenter Survey of Acute Stroke Imaging Protocols for Endovascular Thrombectomy

2020 ◽  
Author(s):  
Byungjun Kim ◽  
Sung-Hye You ◽  
Seung Chai Jung
Keyword(s):  
Acute Stroke ◽  
Time Window ◽  
Current Status ◽  
Late Time ◽  
Endovascular Thrombectomy ◽  
Stroke Imaging ◽  
Imaging Protocols ◽  
Multicenter Survey ◽  
Tertiary Hospitals ◽  
Acute Stroke Imaging

Purpose: Identifying current practices in acute stroke imaging is essential for establishing optimal imaging protocols. We surveyed and assessed the current status of acute stroke imaging for endovascular thrombectomy (EVT) at tertiary hospitals throughout South Korea.Materials and Methods: An electronic questionnaire on imaging protocols for EVT in patients with acute ischemic stroke was e-mailed to physicians at 42 registered tertiary hospitals, and their responses were collected between February and March 2020.Results: Of the 36 hospitals participating in the survey, 69% (25/36) adopted computed tomography (CT)-based protocols, whereas 31% (11/36) adopted magnetic resonance (MR)-based protocols. Non-enhanced CT (NECT) was the initial imaging study at 28%, NECT with CT angiography (CTA) at 36%, and NECT with CTA and CT perfusion (CTP) at 33% of hospitals. Perfusion imaging was performed at 61% (22/36), CTP at 44% (16/36), and MR perfusion at 17% (6/36) of hospitals. Multiphase CTA was performed at 67%, single-phase CTA at 11%, time-of-flight MR angiography (MRA) at 8%, contrast-enhanced MRA at 8%, and both at 6% of hospitals. For late time window stroke, 50% of hospitals used identical imaging protocols to those for early time window stroke, 39% used additional MR imaging (MRI), and 6% converted the imaging strategy from CT to MRI. Post-processing programs were used at 28% (10/36), and RAPID software at 14% (5/36) of hospitals, respectively. Most hospitals (92%) used the same imaging protocols for posterior and anterior circulation strokes.Conclusion: Our multicenter survey demonstrated considerable heterogeneity in acute stroke imaging protocols across South Korean tertiary hospitals, suggesting that hospitals refine their imaging protocols according to hospital-specific conditions.

scholarly journals Acute Stroke Imaging Research Roadmap II

Stroke ◽  
2013 ◽  
Vol 44 (9) ◽  
pp. 2628-2639 ◽  
Author(s):  
Max Wintermark ◽  
Gregory W. Albers ◽  
Joseph P. Broderick ◽  
Andrew M. Demchuk ◽  
Jochen B. Fiebach ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Stroke Imaging ◽  
Imaging Research ◽  
Acute Stroke Imaging

Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke

2018 ◽  
Vol 24 (28) ◽  
pp. 3332-3340 ◽  
Author(s):  
Kyeong-Ah Kwak ◽  
Ho-Beom Kwon ◽  
Joo Won Lee ◽  
Young-Seok Park
Keyword(s):  
Clinical Trials ◽  
Stem Cell ◽  
Ischemic Stroke ◽  
Time Window ◽  
Experimental Studies ◽  
Cell Type ◽  
Stroke Treatment ◽  
Cell Based Therapy ◽  
Regenerative Approach ◽  
Therapeutic Time Window

Stroke is a leading cause of death and disability worldwide. Conventional treatment has a limitation of very narrow therapeutic time window and its devastating nature necessitate a novel regenerative approach. Transplanted stem cells resulted in functional recovery through multiple mechanisms including neuroprotection, neurogenesis, angiogenesis, immunomodulation, and anti-inflammatory effects. Despite the promising features shown in experimental studies, results from clinical trials are inconclusive from the perspective of efficacy. The present review presents a synopsis of stem cell research on ischemic stroke treatment according to cell type. Clinical trials to the present are briefly summarized. Finally, the hurdles and issues to be solved are discussed for clinical application.

scholarly journals The Predictive Value of the Boston Acute Stroke Imaging Scale (BASIS) in Acute Ischemic Stroke Patients among Chinese Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e113967
Author(s):  
Yuanqi Zhao ◽  
Min Zhao ◽  
Xiaomin Li ◽  
Xiancong Ma ◽  
Qinghao Zheng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Stroke ◽  
Acute Ischemic Stroke ◽  
Predictive Value ◽  
Chinese Population ◽  
Stroke Patients ◽  
Stroke Imaging ◽  
Acute Stroke Imaging

Neuroimaging of Acute Stroke

2017 ◽  
Author(s):  
Chelsea S. Kidwell ◽  
Kambiz Nael
Keyword(s):  
Acute Stroke ◽  
Resonance Imaging ◽  
Significant Progress ◽  
Stroke Patients ◽  
The Past ◽  
Stroke Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Noncontrast Computed Tomography ◽  
Acute Stroke Imaging ◽  
Multimodal Ct

The neuroimaging workup for patients with suspected acute ischemic stroke has advanced significantly over the past few decades. Evaluation is no longer limited to noncontrast computed tomography (CT), but now frequently also includes vascular and perfusion imaging. Although acute stroke imaging has made significant progress with the development of multimodal approaches, there are still many unanswered questions regarding their appropriate use in daily patient care. It is important for all physicians taking care of stroke patients to be familiar with current multimodal CT and magnetic resonance imaging (MRI) techniques, including their strengths, limitations, and their role in guiding therapy.

Sign in / Sign up

Export Citation Format

Share Document