scholarly journals Rehabilitation outcome after acute subarachnoid haemorrhage: the role of early functional predictors and complications

Author(s):  
KS Chua ◽  
JJY Loke ◽  
CJ Lim ◽  
JML Thio ◽  
RR Krishnan
Languages ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 36
Author(s):  
Ana de Prada Pérez

Subject pronoun expression (SPE) in Spanish has been widely studied across monolingual and bilingual varieties, showing a consistent effect of functional predictors. In recent papers, the role of the mechanical predictor priming, or perseveration, has been the source of debate. Additionally, little is known about the interaction of perseveration and significant functional predictors (e.g., grammatical person). In this paper, we expand on previous research by examining first-person singular (1sg) and third-person singular (3sg) data from sociolinguistic interviews with Spanish–English bilinguals from Florida to explore the possible difference in priming in deictic vs. referential subjects. The results from a mixed-effects variable rule analysis only offered clear evidence of priming in 1sg. We hypothesize that this result could be due to either surprisal (1sg overt pronominal subjects are rarer in the corpus that 3sg overt pronominal subjects) or to 3sg involving reference-tracking and perseveration only being evident in contexts where the subject form does not signal for pragmatic content.


2007 ◽  
Vol 112 (1) ◽  
pp. 123-137 ◽  
Author(s):  
M. El Khaldi ◽  
P. Pernter ◽  
F. Ferro ◽  
A. Alfieri ◽  
N. Decaminada ◽  
...  

1976 ◽  
Vol 19 (04) ◽  
pp. 144-157
Author(s):  
J. Pecker ◽  
J. Simon ◽  
A. Javalet ◽  
J. Faivre ◽  
G. Guy ◽  
...  

Brain Injury ◽  
2011 ◽  
Vol 25 (10) ◽  
pp. 965-971 ◽  
Author(s):  
Sahika Liva Cengiz ◽  
Mehmet Fatih Erdi ◽  
Mustafa Cihat Avunduk ◽  
Murat Tosun ◽  
Mehmet Erkan Üstün ◽  
...  

2021 ◽  
pp. svn-2021-001028
Author(s):  
Zhiyuan Vera Zheng ◽  
Junfan Chen ◽  
Hao Lyu ◽  
Sin Yu Erica Lam ◽  
Gang Lu ◽  
...  

Background and purposeSignal transducer and activator of transcription 3 (STAT3) may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses. Thus, this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage (SAH).MethodsThe SAH model was established by endovascular perforation in the mouse. Real-time PCR (RtPCR) and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH. To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH, the microglia-specific STAT3 knockout (KO) mice were generated by the Cre-LoxP system. The neurological functions were assessed by Catwalk and Morris water maze tests. Neuronal loss after SAH was determined by immunohistochemistry staining. Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.ResultsThe STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH. Downstream factors and related mediators altered dynamically and accordingly. Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH. To investigate the underlying mechanism, we examined the microglial reaction after STAT3 KO. STAT3 deletion reversed the increase of microglia after SAH. Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation. Functionally, microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.ConclusionsSTAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation. Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH. STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH.


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