Glycogen Synthase Kinase-3 Is Required For Transforming Growth Factor-²-induced Myofibroblast Differentiation

2010 ◽  
Author(s):  
Hoeke A. Baarsma ◽  
Lilian H.J.M. Engelbertink ◽  
Dirkje S. Postma ◽  
Wim Timens ◽  
Herman Meurs ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Myofibroblast Differentiation

scholarly journals The Fibroblast Growth Factor 14·Voltage-gated Sodium Channel Complex Is a New Target of Glycogen Synthase Kinase 3 (GSK3)

2013 ◽  
Vol 288 (27) ◽  
pp. 19370-19385 ◽  
Author(s):  
Alexander S. Shavkunov ◽  
Norelle C. Wildburger ◽  
Miroslav N. Nenov ◽  
Thomas F. James ◽  
Tetyana P. Buzhdygan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Sodium Channel ◽  
Fibroblast Growth Factor ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Fibroblast Growth ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

scholarly journals The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells

1994 ◽  
Vol 303 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Y Saito ◽  
J R Vandenheede ◽  
P Cohen
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
A431 Cells ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Epidermal Growth

Glycogen synthase kinase 3 (GSK3) was inhibited by 50% within 5 min when A431 cells were stimulated with epidermal growth factor (EGF). The inhibition was unaffected by rapamycin at concentrations which blocked the activation of p70 S6 kinase, and reversed by incubation with protein phosphatase-1. EGF stimulation of A431 cells inhibited GSK3 alpha and GSK3 beta to a similar extent, and inhibition was accompanied by phosphorylation of the tryptic peptides containing the serine residues phosphorylated in vitro by p70 S6 kinase or MAP kinase-activated protein (MAPKAP) kinase-1 beta (also termed Rsk-2). These results demonstrate that EGF inhibits GSK3 by inducing phosphorylation of a serine residue and that GSK3 is not phosphorylated in vivo by either p70 S6 kinase or protein kinase C.

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