Cigarette Smoke Activates PI3 Kinase Pathway and Downregulates MicroRNA-1 in Non-Small Cell Lung Cancer (NSCLC)

2019 ◽  
Author(s):  
A. Korde ◽  
A. Ramaswami ◽  
M.S. Godfrey ◽  
S. Anderson ◽  
S. Takyar
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Pi3 Kinase ◽  
Small Cell Lung ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals miRNA and proteomic dysregulation in non-small cell lung cancer in response to cigarette smoke

2017 ◽  
Vol 1 (Special Issue-Supplement) ◽  
pp. 244-244
Author(s):  
Niraj Babu ◽  
Jayshree Advani ◽  
Hitendra S. Solanki ◽  
Krishna Patel ◽  
Ankit Jain ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

High Kpnβ1 expression promotes non-small cell lung cancer proliferation and chemoresistance via the PI3-kinase/AKT pathway

2018 ◽  
Vol 51 ◽  
pp. 39-48 ◽  
Author(s):  
Haiying Wang ◽  
Danping Wang ◽  
Chunsun Li ◽  
Xingsong Zhang ◽  
Xiaolin Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Pi3 Kinase ◽  
Akt Pathway ◽  
Small Cell Lung ◽  
Cancer Proliferation

Cigarette Smoke-Induced Reduction of 14-3-3σ Expression Promotes The Progression of Non-Small Cell Lung Cancer

2021 ◽  
Author(s):  
Longxia Dai ◽  
Quanwen Deng ◽  
Aibin Liu ◽  
Shuya He ◽  
Qiong Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Expression ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
A549 Cells ◽  
Small Cell ◽  
Small Cell Lung ◽  
Smoking Group ◽  
The Relationship

Abstract Background Lung cancer is a common malignant tumour and the leading cause of cancer death. Smoking is closely related to lung cancer, which can not only induce the occurrence of lung cancer but also affect its progress and prognosis. Objectives To investigated the relationship between smoking and 14-3-3σ protein expression in non-small-cell lung cancer (NSCLC), investigated the relationship between 14-3-3σ expression and cell migration in A549 cells induced by cigarette smoke extract (CSE) and explored whether DNA methylation plays a role in the decreased expression of 14-3-3σ induced by CSE. Methods 14-3-3σ protein expression was examined by immunohistochemistry in 152 NSCLC tissue samples. In vitro experiments were divided into three groups: The current smoking group (CS), the ex-smoking group (ES) and the normal control group (NC). Cell transfection was used for 14-3-3σ protein overexpression. The mRNA and protein expression levels of 14-3-3σ were detected by RT-PCR and Western blotting, respectively. Cell migration was detected by Transwell and wound-healing assays, and the methylation of 14-3-3σ was detected by methylation-specific PCR. Results 14-3-3σ protein expression was decreased in NSCLC patients with a history of smoking. The expression of 14-3-3σ was decreased in A549 cells treated with CSE. The migration capacity of A549 cells treated with CSE was enhanced. DNA methylation in the cigarette smoke-treated A549 cells was higher than that in the untreated cells. Conclusion Cigarette smoke induced reduction of 14-3-3σ expression can promote the progression of non-small cell lung cancer.

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

2011 ◽  
Vol 459 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Lei Xu ◽  
Xiao-yun Mao ◽  
Chui-feng Fan ◽  
Hua-chuan Zheng
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Characterisation of the Phosphatidylinositol 3-Kinase Pathway in Non-Small Cell Lung Cancer Cells Isolated from Pleural Effusions

Oncology ◽  
2016 ◽  
Vol 90 (5) ◽  
pp. 280-288 ◽  
Author(s):  
Martina Puglisi ◽  
Adam Stewart ◽  
Parames Thavasu ◽  
Michael Frow ◽  
Suzanne Carreira ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Pleural Effusions ◽  
Phosphatidylinositol 3 Kinase ◽  
Small Cell Lung ◽  
Kinase Pathway

scholarly journals Multi-Level Targeting of the Phosphatidylinositol-3-Kinase Pathway in Non-Small Cell Lung Cancer Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31331 ◽  
Author(s):  
Christopher R. Zito ◽  
Lucia B. Jilaveanu ◽  
Valsamo Anagnostou ◽  
David Rimm ◽  
Gerold Bepler ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Phosphatidylinositol 3 Kinase ◽  
Small Cell Lung ◽  
Multi Level ◽  
Kinase Pathway

scholarly journals Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (38) ◽  
pp. 61229-61245 ◽  
Author(s):  
Remya Raja ◽  
Nandini A. Sahasrabuddhe ◽  
Aneesha Radhakrishnan ◽  
Nazia Syed ◽  
Hitendra S. Solanki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Chronic Exposure ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung
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