Smooth Muscle Enriched Long Noncoding RNA (SMILR) Is Implicated in the Progression of Pulmonary Hypertension

2019 ◽  
Author(s):  
T. Mertens ◽  
S. Collum ◽  
C. Wilson ◽  
B. Weizhen ◽  
R. Thandavarayan ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Smooth Muscle ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension

2020 ◽  
Vol 319 (2) ◽  
pp. H377-H391 ◽  
Author(s):  
Si Lei ◽  
Fei Peng ◽  
Mei-Lei Li ◽  
Wen-Bing Duan ◽  
Cai-Qin Peng ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Long Noncoding Rna ◽  
Vascular Remodeling ◽  
Noncoding Rna ◽  
In Vivo Models ◽  
Pulmonary Arterial

Smooth muscle-enriched long noncoding RNA (SMILR), as a long noncoding RNA (lncRNA), was increased in pulmonary arterial hypertension (PAH) patients and in vitro and in vivo models. SMILR activated RhoA/ROCK signaling by targeting miR-141 to disinhibit its downstream target RhoA. SMILR knockdown or miR-141 overexpression inhibited hypoxia-induced cell proliferation and migration via repressing RhoA/ROCK signaling in pulmonary arterial smooth muscle cells (PASMCs), which was confirmed in vivo experiments that knockdown of SMILR inhibited vascular remodeling and alleviated PAH in rats. SMILR may be a promising and novel therapeutic target for the treatment and drug development of PAH.

scholarly journals The Long Noncoding RNA MEG3 Is an Emerging Factor in Hypoxia-Induced Pulmonary Hypertension

2016 ◽  
Vol 35 (4) ◽  
pp. S358 ◽  
Author(s):  
M. Brock ◽  
C. Schuoler ◽  
S. Ulrich ◽  
R. Speich ◽  
M. Gassmann ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Long Noncoding Rna ◽  
Noncoding Rna
Sign in / Sign up

Export Citation Format

Share Document