scholarly journals Community Acquired Pneumonia Secondary to Multiple Drug Resistant Providencia Stuartii: A Case Report

Author(s):  
M.K.E. Ogbac ◽  
J.E.V. Tamayo
2020 ◽  
Vol 7 (2) ◽  
pp. 257-259
Author(s):  
Tanish Baqar ◽  
Sharique Ahmad ◽  
Silky Rai

Multiple drug-resistant tuberculosis (MDR-TB) is a critical situation affecting adults as properly as children across the globe (1). To determine the incidence and risk factors associated with Multiple Drug Resistant Tuberculosis (MDR-TB) (2), we studied Ototoxicity on 18 culture confirmed MDR-TB patients in Eras' Lucknow Medical College and Hospital, Lucknow from September, 2019 to January, 2020. This case follows a well documented report of a patient describing an unusual and novel occurrence of ototoxicity when undergoing treatment concerning multiple drug resistance tuberculosis along with symptoms, signs, diagnosis, treatment and follow-up (3). For descriptive convenience, the patient will be classified as patient 1. The following case is the cornerstones of medical progress and provides many new ideas in medicine. Containing an extensive review of the relevant literature on the topic, the case report is a rapid short communication between busy clinicians who may not have time or resources to conduct large scale research.(4)


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zachary D. Aron ◽  
Atousa Mehrani ◽  
Eric D. Hoffer ◽  
Kristie L. Connolly ◽  
Pooja Srinivas ◽  
...  

AbstractBacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery of a family of acylaminooxadiazoles that selectively inhibit trans-translation, the main ribosome rescue pathway in bacteria. Here, we report optimization of the pharmacokinetic and antibiotic properties of the acylaminooxadiazoles, producing MBX-4132, which clears multiple-drug resistant Neisseria gonorrhoeae infection in mice after a single oral dose. Single particle cryogenic-EM studies of non-stop ribosomes show that acylaminooxadiazoles bind to a unique site near the peptidyl-transfer center and significantly alter the conformation of ribosomal protein bL27, suggesting a novel mechanism for specific inhibition of trans-translation by these molecules. These results show that trans-translation is a viable therapeutic target and reveal a new conformation within the bacterial ribosome that may be critical for ribosome rescue pathways.


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