Increase of C-Reactive Protein and Decrease of Surfactant Protein A in Surfactant after Lung Transplantation

1998 ◽  
Vol 157 (1) ◽  
pp. 43-49 ◽  
Author(s):  
CRISTINA CASALS ◽  
ANDRÉS VARELA ◽  
MIGUEL L. F. RUANO ◽  
FERNANDO VALIÑO ◽  
JESÚS PÉREZ-GIL ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
C Reactive Protein ◽  
Reactive Protein

Disparate effects of two phosphatidylcholine binding proteins, C-reactive protein and surfactant protein A, on pulmonary surfactant structure and function

2004 ◽  
Vol 287 (6) ◽  
pp. L1145-L1153 ◽  
Author(s):  
Kaushik Nag ◽  
Karina Rodriguez-Capote ◽  
Amiya Kumar Panda ◽  
Laura Frederick ◽  
Stephen A. Hearn ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Amorphous Material ◽  
Protein A ◽  
Surfactant Protein ◽  
Water Soluble ◽  
Surfactant Protein A ◽  
Surface Films ◽  
Inhibitory Effects ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. We examined the effects of CRP and SP-A on the surface activity of bovine lipid extract surfactant (BLES), a clinically applied modified natural surfactant. CRP inhibited BLES adsorption to form a surface-active film and the film's ability to lower surface tension (γ) to low values near 0 mN/m during surface area reduction. The inhibitory effects of CRP were reversed by phosphorylcholine, a water-soluble CRP ligand. SP-A enhanced BLES adsorption and its ability to lower γ to low values. Small amounts of SP-A blocked the inhibitory effects of CRP. Electron microscopy showed CRP has little effect on the lipid structure of BLES. SP-A altered BLES multilamellar vesicular structure by generating large, loose bilayer structures that were separated by a fuzzy amorphous material, likely SP-A. These studies indicate that although SP-A and CRP both bind PC, there is a difference in the manner in which they interact with surface films.

Fluidizing effects of C‐reactive protein on lung surfactant membranes: protective role of surfactant protein A

2010 ◽  
Vol 24 (10) ◽  
pp. 3662-3673 ◽  
Author(s):  
Alejandra Saenz ◽  
Almudena López‐Sánchez ◽  
Jonás Mojica‐Lázaro ◽  
Leticia Martínez‐Caro ◽  
Nicolas Nin ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Protective Role ◽  
Surfactant Protein A ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Low Levels of Exhaled Surfactant Protein A Associated With BOS After Lung Transplantation

2016 ◽  
Vol 2 (9) ◽  
pp. e103 ◽  
Author(s):  
Petrea A. Ericson ◽  
Ekaterina Mirgorodskaya ◽  
Oscar S. Hammar ◽  
Emilia A. Viklund ◽  
Ann-Charlotte R. Almstrand ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Low Levels
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