scholarly journals Carpal Tunnel Syndrome in Hypothyroid Patients: The Effect of Hormone Replacement Therapy

2014 ◽  
Vol 2 (3) ◽  
pp. 54 ◽  
Author(s):  
Arafat A. Kasem
Keyword(s):  
Hormone Replacement Therapy ◽  
Carpal Tunnel Syndrome ◽  
Replacement Therapy ◽  
Carpal Tunnel ◽  
Hormone Replacement ◽  
Tunnel Syndrome ◽  
Hypothyroid Patients

scholarly journals Response of carpal tunnel syndrome to hormone replacement therapy.

BMJ ◽  
1991 ◽  
Vol 303 (6816) ◽  
pp. 1514-1514 ◽  
Author(s):  
R Confino-Cohen ◽  
M Lishner ◽  
H Savin ◽  
R Lang ◽  
M Ravid
Keyword(s):  
Hormone Replacement Therapy ◽  
Carpal Tunnel Syndrome ◽  
Replacement Therapy ◽  
Carpal Tunnel ◽  
Hormone Replacement ◽  
Tunnel Syndrome

scholarly journals Carpal tunnel syndrome and hormone replacement therapy.

BMJ ◽  
1992 ◽  
Vol 304 (6823) ◽  
pp. 382-382 ◽  
Author(s):  
G. M. Hall ◽  
T. D. Spector ◽  
J. W. Studd
Keyword(s):  
Hormone Replacement Therapy ◽  
Carpal Tunnel Syndrome ◽  
Replacement Therapy ◽  
Carpal Tunnel ◽  
Hormone Replacement ◽  
Tunnel Syndrome

scholarly journals Association between hormone replacement therapy and carpal tunnel syndrome: a nationwide population-based study

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e055139
Author(s):  
Hsien-Chin Tang ◽  
Ya-Yun Cheng ◽  
How-Ran Guo
Keyword(s):  
Rheumatoid Arthritis ◽  
Health Insurance ◽  
Hormone Replacement Therapy ◽  
Carpal Tunnel Syndrome ◽  
Replacement Therapy ◽  
Carpal Tunnel ◽  
Hormone Replacement ◽  
Age Groups ◽  
Population Based ◽  
Tunnel Syndrome

ObjectiveCarpal tunnel syndrome (CTS) is the most common compressive focal mononeuropathy, and the increased incidence in postmenopausal and pregnant women suggests its association with oestrogen. The objective of this study is to evaluate the relationship between hormone replacement therapy (HRT) and the occurrence of CTS.DesignPopulation-based case-control study.SettingNationwide health insurance programme operated by the government with a near 100% coverage rate.ParticipantsWe identified women ≥45 years old in the Health Insurance Research Database of Taiwan, which contains data on a representative sample of one million enrollees. After exclusion of those who were diagnosed with CTS before the prescription of HRT, a total of 118 309 participants were included and followed up for 15 years starting from 1 January 1996. Both HRT and occurrence of CTS were identified using the insurance claims.Main outcome measuresWe identified incident patients of CTS and evaluated the association between HRT and CTS by calculating the OR.ResultsOf the 4535 participants who developed CTS during the study period, 2334 (51.5%) were HRT recipients. In participants without CTS, the proportion of HRT recipients was 28.1%, yielding an OR of 2.72 with a 95% CI of 2.56 to 2.88. After adjustment for age, diabetes, rheumatoid arthritis, hypothyroidism, gout and obesity, the OR of CTS associated with HRT was 2.04 (95% CI 1.91 to 2.17). While HRT, diabetes, rheumatoid arthritis and gout had similar effects on CTS across all age groups, hypothyroidism and obesity had different effects on different groups.ConclusionThis study observed a positive association between HRT and CTS, independent of age, diabetes, rheumatoid arthritis, hypothyroidism, gout and obesity. While the ORs of CTS associated with HRT were similar across age groups, those associated with hypothyroidism and obesity were not, indicating effect modifications by age.

ELECTRODIAGNOSTIC CRITERIA FOR DIAGNOSING CARPAL TUNNEL SYNDROME NEED TO BE REVISED IN HYPOTHYROID PATIENTS

2017 ◽  
Vol 20 (03) ◽  
pp. 1750014
Author(s):  
Mahdieh Asadi ◽  
Sharareh Roshanzamir
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Control Group ◽  
Tunnel Syndrome ◽  
Clinical Signs And Symptoms ◽  
Relationship Of ◽  
Hypothyroid Patients

Background: Previous studies do not agree with each other on the association between electrodiagnostic findings and clinical symptoms of Carpal tunnel syndrome (CTS). In most of these studies, many variables such as age, sex, obesity and hypothyroidism have not been taken into account. Material & methods: About 62 patients with hypothyroidism and 62 patients without hypothyroidism with sign and symptoms of CTS were included in this study. Electrodiagnostic tests were done for all patients. And relationship of the severity of CTS signs and symptoms with electrodiagnostic parameters was examined statistically in each group. Results: This study showed that distal motor latency in control group (without hypothyroidism) is significantly more prolonged than hypothyroid patients. Also there was significant correlation between clinical symptoms and electrodiagnostic findings in control group, but there was not such correlation in hypothyroid patients. In 62% of hypothyroid patients with clinical signs and symptoms of CTS, electrodiagnostic findings were normal and only in 38% of cases, electrodiagnostic findings were suggestive of CTS. Conclusion: Relationship of the severity of CTS signs and symptoms with electrodiagnostic parameters is very weak in hypothyroid patients. Many hypothyroid patients with clinical signs and symptoms of CTS have normal electrodiagnostic findings; so we need more studies for revising the para-clinic criteria of labeling patients having CTS in hypothyroid patients.

RATIONAL FOR HYPOTHYROIDISM SCREENING IN CARPAL TUNNEL SYNDROME PATIENTS WITHOUT DEFINITE PREDISPOSING FACTOR

2016 ◽  
Vol 19 (04) ◽  
pp. 1650020 ◽  
Author(s):  
Sharareh Roshanzamir ◽  
Amid Azarang ◽  
Alireza Dabbaghmanesh
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Subclinical Hypothyroidism ◽  
Control Group ◽  
Normal Female ◽  
Predisposing Factor ◽  
Study Materials ◽  
Tunnel Syndrome ◽  
Carpal Tunnel Questionnaire ◽  
Hypothyroid Patients

Background: Screening for hypothyroidism in carpal tunnel syndrome (CTS) patients is of controversy. To determine the value of hypothyroidism screening in CTS patients without definite predisposing factor we designed this study. Materials and Methods: 220 normal female and 220 female with CTS were included. We excluded any patient with a definite predisposing factor for CTS such as trauma, being manual laborer, etc. Boston carpal tunnel questionnaire was filled for each CTS patient and all the patients went under electrodiagnostic study; and a blood sample was taken to measure TSH and T4 level. Results: The prevalence of subclinical hypothyroidism was 38.2% among the CTS group, and 11.8% in control group. The level of TSH was above 10[Formula: see text]mU/L (cut off level for treatment) in 45.2% of subclinical hypothyroid patients with CTS and 11.5% of subclinical hypothyroid patients without CTS. In the subclinical hypothyroid patients with CTS there was a significant direct correlation between TSH values and the Boston questionnaire scoring (correlation coefficient with function score: 0.93 and with symptom score: 0.96) ([Formula: see text]). Conclusion: Regarding high prevalence of subclinical hypothyroidism in CTS patients without definite predisposing factor and direct association of TSH level with symptom severity we recommend screening for hypothyroidism in these patients.

scholarly journals DYNAMICS OF CLINICAL AND ELECTROPHYSIOLOGICAL CHARACTERISTICS OF CARPAL TUNNEL SYNDROME IN CHILDREN WITH MUCOPOLYSACCHARIDOSES AGAINST THE BACKGROUND OF ENZYME-REPLACEMENT THERAPY

2019 ◽  
Vol 21 (3) ◽  
pp. 152-156
Author(s):  
Liliya L. Osipova ◽  
L. M. Kuzenkova ◽  
A. L. Kurenkov ◽  
T. V. Podkletnova ◽  
L. S. Namazova-Baranova ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Median Nerve ◽  
Carpal Tunnel ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Enzyme Replacement ◽  
Tunnel Syndrome ◽  
The Impact

Introduction. Mucopolysaccharidoses are the most common cause of the carpal tunnel syndrome in children. Enzyme-replacement therapy, which is available in clinical practice within last 10-15 years for mucopolysaccharidoses I, II and VI demonstrated the efficacy regarding somatic symptoms of the diseases, however, the impact of this new pathogenetic treatment on neuropathy of median nerve, arising from compression in the carpal tunnel, is poorly described. Objective. To study the dynamics of clinical and electrophysiological characteristics of carpal tunnel syndrome in children with mucopolysaccharidoses during enzyme-replacement therapy. Materials and methods. 18 children with mucopolysaccharidoses I, II and VI, received enzyme-replacement therapy, are included in the study. Dynamics of clinical symptoms of the carpal tunnel syndrome and EMG indices of median nerve testing are described against the background of enzyme-replacement therapy. Results. Objective and subjective clinical manifestations of the carpal tunnel syndrome persisted or appeared in children, receiving enzyme-replacement therapy for 21±12 months. However, there were no statistically significant changes in EMG-characteristics of median nerves testing during enzyme-replacement therapy in children with mucopolysaccharidoses Conclusion. Enzyme-replacement therapy in children with mucopolysaccharidoses I, II and VI may suspend and/or delay progressive damage of median nerves in the carpal canal, thus indicating prevention and slowing down in glycosaminoglycans storage in the carpal tunnel.

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