Prediction and Depiction of Potential RNA-Based Therapeutics for Oncogenic E6 and E7 Genes of Human Papilloma Virus Types 16 & 18: A New Class of Treatment for Lung Cancer

Human papilloma virus (HPV), known to be an etiological agent for genital cancers, has been suggested also to be a possible contributory agent for lung cancer. Alternatively, lung cancer, formerly considered to be solely a smoker's disease, may now be more appropriately categorised into never smoker's and smoker's lung cancer. Through this paper we attempt to bring forth the current knowledge regarding mechanisms of HPV gaining access into the lung tissue, various strategies involved in HPV-associated tumorigenesis in lung tissue.

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Binase treatment increases interferon sensitivity and apoptosis in SiHa cervical carcinoma cells by downregulating E6 and E7 human papilloma virus oncoproteins

Oncotarget ◽

10.18632/oncotarget.20199 ◽

2017 ◽

Vol 8 (42) ◽

pp. 72666-72675 ◽

Cited By ~ 5

Author(s):

Vladimir A. Mitkevich ◽

Ksenia M. Burnysheva ◽

Irina Yu Petrushanko ◽

Alexei A. Adzhubei ◽

Alexey A. Schulga ◽

...

Keyword(s):

Human Papilloma Virus ◽

Cervical Carcinoma ◽

Carcinoma Cells ◽

Papilloma Virus ◽

E6 And E7

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Involvement of p53-dependent apoptosis signal in antitumor effect of Colchicine on human papilloma virus (HPV)-positive human cervical cancer cells

Bioscience Reports ◽

10.1042/bsr20194065 ◽

2020 ◽

Vol 40 (3) ◽

Author(s):

Luchun Yan ◽

Hao Huang ◽

Ying Zhang ◽

Xinrong Yuan ◽

Zhaohua Yan ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papilloma Virus ◽

Colchicine Treatment ◽

Inhibitory Effect ◽

Epidermal Keratinocytes ◽

Human Epidermal Keratinocytes ◽

Papilloma Virus ◽

Treatment And Prevention ◽

E6 And E7 ◽

Human Cervical Cancer

Abstract Colchicine, a plant-derived alkaloid with relatively low toxicity on normal human epidermal keratinocytes (HEKn), has selective inhibitory effect on the growth of CaSki (HPV16-positive) and HeLa (HPV18-positive) human cervical cancer cell lines via the induction of apoptosis. Colchicine (2.5, 5.0 and 10.0 ng/ml) significantly reduced the expression of human papilloma virus (HPV) 16 E6/E7 mRNA and protein in CaSki and HeLa cells. Moreover, reduced expression of E6 and E7 induced by Colchicine resulted in the up-regulation of tumor suppressor proteins, p53 and Rb, as well as down-regulation of phospho Rb (pRb) protein. In addition, Bax, cytosolic cytochrome c and cleaved caspase-3 protein were increased while Bcl-2 protein was decreased significantly by 48 h of Colchicine treatment. These results implied that Colchicine could be explored as a potent candidate agent for the treatment and prevention of HPV-associated cervical cancer without deleterious effects.

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Humoral Immune Response against Proteins E6 and E7 in Cervical Carcinoma Patients Positive for Human Papilloma Virus Type 16 during Treatment and Follow-Up

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/s100960050240 ◽

1999 ◽

Vol 18 (2) ◽

pp. 126-132 ◽

Cited By ~ 16

Author(s):

M. F. D. Baay ◽

J. M. Duk ◽

M. P. M. Burger ◽

H. W. A. de Bruijn ◽

E. Stolz ◽

...

Keyword(s):

Immune Response ◽

Human Papilloma Virus ◽

Virus Type ◽

Cervical Carcinoma ◽

Humoral Immune Response ◽

Human Papilloma Virus Type ◽

Papilloma Virus ◽

Humoral Immune ◽

E6 And E7

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A Comprehensive Review on Crosstalk of Human Papilloma Virus oncoproteins and developmental/self-renewal pathways during the pathogenesis of uterine cervical cancer

Current Molecular Medicine ◽

10.2174/1566524020666200925160015 ◽

2020 ◽

Vol 20 ◽

Author(s):

Afza Ahmad ◽

Irfan Ahmad Ansari

Keyword(s):

Cervical Cancer ◽

Human Papilloma Virus ◽

Epithelial Mesenchymal Transition ◽

Wnt Signaling Pathway ◽

Hpv Infection ◽

Uterine Cervical Cancer ◽

Self Renewal ◽

Papilloma Virus ◽

Mesenchymal Transition ◽

E6 And E7

: Cervical cancer, a cancer arising from the uterine cervix has been regarded as the fourth most frequent gynecological malignancy among females worldwide. Epidemiological reports have shown that uterine cervical cancer is a global health issue among womens of specially developing countries and consequently creates an economic and medical burden in the society. The main causative agent of cervical carcinoma is high risk human papilloma virus (HPV 16 and HPV 18). Molecular studies have revealed the expression two viral genes E6 and E7 after HPV infection in the epithelial cells of cervix. These gene products are known to inactivate the major tumor suppressors, p53 and retinoblastoma protein (pRB), respectively. Moreover, the role of self-renewal pathways such as Hedgehog, Notch and Wnt has also been linked with drug resistance in cancer cells and epithelial mesenchymal transition during metastasis in pathogenesis of cervical cancer. Although, the mechanism of interaction of HPV E6 and E7 with each and every component of above described developmental pathways is not elucidated yet, but preliminary reports of their crosstalk have begun to emerge. Understanding the interplay between these oncoproteins and developmental/self-renewal pathways is highly important in terms of designing new and targeted therapeutic approach against cervical cancer. Hence, this review cynosure the carcinogenesis of HPV with the brief description of its virology and also establishes the crosstalk between oncoproteins E6 & E7 and Hedgehog, Notch and Wnt signaling pathway.

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