Knowing Ahead Mathematical Determinant of Bank Customers Credit Worthiness: A Safe Strategy for Funding Loan in a Critical Economy

Background: Evidence about the use of dolutegravir (DTG) and rilpivirine (RPV) as an antiretroviral therapy (ART) in treatment-experienced patients is scarce. Objective: To explore the effectiveness, safety, and costs of switching to a DTG plus RPV regimen in this population. Methods: This observational, prospective study included all treatment-experienced patients who switched to DTG plus RPV between November 2014 and July 2016. Patients were excluded if resistance mutations to integrase inhibitors or RPV were found. The effectiveness endpoint was the proportion of patients who achieved virological suppression (viral load [VL] <50 copies/mL) at week 48 (W48). Safety (incidence of adverse events leading to discontinuation and laboratory abnormalities), adherence, and costs were analyzed. Results: A total of 35 patients were included, and 91.4% were virologically suppressed at baseline. Patients were treated with ART for a median of 14 years (interquartile range = 7-20). At W48, 91.4% of patients were virologically suppressed (95% CI = 77.0-98.2). Two of the 3 patients not suppressed at baseline achieved undetectable VL at W48, and 2 patients discontinued DTG plus RPV (intolerance and a drug-drug interaction). None of the virologically suppressed patients at baseline showed virological rebound through W48. There were no significant changes in lipid, liver, and renal profiles. The proportion of patients with an ART adherence >90% increased from 65.6% to 93.8% ( P = 0.004). The annual per-patient ART costs dropped by €665 ( P = 0.265). Conclusions: Switching to DTG plus RPV seems to be an effective and safe strategy. Significant improvements in patients’ adherence and costs were achieved.

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Modelling Mortgage Insurance Claims Experience: A Case Study

Astin Bulletin ◽

10.2143/ast.24.1.2005084 ◽

1994 ◽

Vol 24 (1) ◽

pp. 97-129 ◽

Cited By ~ 1

Author(s):

Greg Taylor

Keyword(s):

Geographic Location ◽

Real Data ◽

Internal Variables ◽

Functional Dependencies ◽

Data Set ◽

Mortgage Insurance ◽

Section 8 ◽

Sequence Of Events ◽

Claim Frequency ◽

Credit Worthiness

AbstractMortgage insurance indemnifies a mortage lender against loss on default by the borrower. The sequence of events leading to a claim under this type of insurance is relatively complex, depending not only on the credit worthiness of the borrower but also on a number of external economic factors.Prominent among these external factors are the loan to valuation ratio of the insured loan, the disposable income of the borrower, and movements in property values. A broad theoretical model of the functional dependencies of claim frequency and average claim size on these variables is established in Sections 6 and 7. Section 8 fits these models, extended by other “internal” variables such as the geographic location of the mortgaged property, to a real data set.Section 9 compares the fitted model with the data, and finds an acceptable fit despite extreme fluctuations in the claims experience recorded in the data set.

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Two-stage free latissimus dorsi flap: A safe strategy for reconstruction of large defects of the abdominal wall

Journal of Plastic Surgery and Hand Surgery ◽

10.3109/2000656x.2012.748311 ◽

2013 ◽

Vol 47 (3) ◽

pp. 232-233 ◽

Cited By ~ 2

Author(s):

Nawfal Fejjal ◽

Jawad Hafidi ◽

Redouane Belmir ◽

Samir El Mazouz ◽

Abdellah Abbassi ◽

...

Keyword(s):

Abdominal Wall ◽

Latissimus Dorsi ◽

Latissimus Dorsi Flap ◽

Two Stage ◽

Safe Strategy ◽

Free Latissimus Dorsi Flap

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Bridge-therapy with enoxaparin in the preoperative period of endarterectomy

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2010000500019 ◽

2010 ◽

Vol 68 (5) ◽

pp. 775-777

Author(s):

Jair Leopoldo Raso ◽

Rogério Zenóbio Darwich ◽

Francisco de Lucca Jr ◽

Romeu Valle Santana ◽

Marco Túlio Tanure ◽

...

Keyword(s):

Molecular Weight ◽

Mortality Rate ◽

Prospective Study ◽

Low Molecular Weight Heparin ◽

The Other ◽

Low Molecular Weight ◽

Preoperative Period ◽

Safe Strategy ◽

A Prospective Study ◽

Bridge Therapy

Cervical clot is one of the complications of endarterectomy. This risk may be higher in patients using aspirin or clopidogrel. On the other hand, stroke may occur if the medication is interrupted before surgery. We carried out a prospective study of 124 endarterectomies in 119 patients in which aspirin or clopidogrel was stopped and a bridge-therapy with enoxaparin was administered preoperatively. There was no case of stroke during the period of the bridge-therapy. One patient developed cervical clot (0.8%) in the fifth postoperative day. Mortality rate in this series was 0.8%. There was no complication directly related to the use of enoxaparin. Bridge-therapy with low molecular weight heparin is a safe strategy for patients elected for endarterectomy

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Correction: Abacavir/Lamivudine plus Rilpivirine Is an Effective and Safe Strategy for HIV-1 Suppressed Patients: 48 Week Results of the SIMRIKI Retrospective Study

PLoS ONE ◽

10.1371/journal.pone.0172184 ◽

2017 ◽

Vol 12 (2) ◽

pp. e0172184

Author(s):

Jesús Troya ◽

Pablo Ryan ◽

Esteban Ribera ◽

Daniel Podzamczer ◽

Victor Hontañón ◽

...

Keyword(s):

Retrospective Study ◽

Safe Strategy ◽

Hiv 1

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394: Modified Single Shot ATG Induction Followed by Postoperative CNI Holiday: A Renal Sparing and Safe Strategy after Heart Transplantation!

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2007.11.405 ◽

2008 ◽

Vol 27 (2) ◽

pp. S203

Author(s):

F.M. Wagner ◽

J. Schirmer ◽

S. Meyer ◽

M. Kubik ◽

H. Treede ◽

...

Keyword(s):

Heart Transplantation ◽

Single Shot ◽

Safe Strategy

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Making a Traditional Spine Surgery Clinic Telemedicine-Ready in the “New Normal” of Coronavirus Disease 2019

Asian Spine Journal ◽

10.31616/asj.2020.0508 ◽

2021 ◽

Vol 15 (2) ◽

pp. 164-171

Author(s):

Ka-Po Gabriel Liu ◽

Wei Loong Barry Tan ◽

Wei Luen James Yip ◽

Jun-Hao Tan ◽

Hee-Kit Wong

Keyword(s):

Spine Surgery ◽

Disease Transmission ◽

Selection Criteria ◽

Herd Immunity ◽

Clinical Protocol ◽

New Normal ◽

Safe Strategy ◽

Healthcare Crisis ◽

Patient Selection Criteria ◽

Outpatient Practice

Study Design: An original article describing a comprehensive methodology for making a traditional spine surgery clinic telemedicineready in terms of logistical considerations and workflow.Purpose: The aim of this study is to promote the use of telemedicine via videoconferencing to reduce human exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reduce the risk of coronavirus disease 2019 (COVID-19) transmission at outpatient clinics.Overview of Literature: The COVID-19 pandemic is the biggest healthcare crisis in the 21st century. Until a vaccine is developed or herd immunity against SARS-CoV-2 is achieved, social distancing to avoid crowding is an important strategy to reduce disease transmission and resurgence. Telemedicine has already been applied in the field of orthopedics with encouraging results.Methods: We reviewed the evidence behind telemedicine and described our clinical protocol, patient selection criteria, and workflow for telemedicine. We discussed a simple methodology to convert pre-existing traditional clinic resources into telemedicine tools, along with future challenges.Results: Our methodology was successfully and easily applied in our clinical practice, with a streamlined workflow allowing our spine surgery service to implement telemedicine as a consultation modality in line with the national recommendations of social distancing.Conclusions: Telemedicine was well incorporated into our outpatient practice using the above workflow. We believe that the use of telemedicine via videoconferencing can become part of the new normal and a safe strategy for healthcare systems as both a medical and an economic countermeasure against COVID-19.

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