The research on the reform of the ability-oriented innovation and entrepreneurship education system is of great significance to promote the quality and entrepreneurship of graduates in product design major of the application-oriented colleges and universities. Aiming to foster students' innovation and entrepreneurship abilities and serve the local economy, the five-in-one education mode integrates with weekly cultivation plan, theoretical teaching, practical teaching, graduation project, and innovation and entrepreneurship program, which is available to deepen the education reform of the product design major, accelerate the application-oriented transformation, and achieve high employment and entrepreneurship rate of graduates.