Interleukin-1 alpha mediates the enhanced expression of intercellular adhesion molecule-1 in pulmonary epithelial cells infected with respiratory syncytial virus.

1995 ◽  
Vol 13 (5) ◽  
pp. 602-609 ◽  
Author(s):  
J A Patel ◽  
M Kunimoto ◽  
T C Sim ◽  
R Garofalo ◽  
T Eliott ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Interleukin 1 ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Pulmonary Epithelial Cells ◽  
Enhanced Expression ◽  
Syncytial Virus

Mechanical Stress Upregulates Intercellular Adhesion Molecule-1 in Pulmonary Epithelial Cells

Respiration ◽  
2008 ◽  
Vol 76 (3) ◽  
pp. 344-350 ◽  
Author(s):  
Xiaobo Hu ◽  
Youyi Zhang ◽  
Deyun Cheng ◽  
Yu Ding ◽  
Dongmei Yang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mechanical Stress ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Pulmonary Epithelial Cells

scholarly journals Essential Roles of NF-κB and C/EBP in the Regulation of Intercellular Adhesion Molecule-1 after Respiratory Syncytial Virus Infection of Human Respiratory Epithelial Cell Cultures

1998 ◽  
Vol 72 (2) ◽  
pp. 1623-1626 ◽  
Author(s):  
B. A. Chini ◽  
M. A. Fiedler ◽  
L. Milligan ◽  
T. Hopkins ◽  
J. M. Stark
Keyword(s):  
Respiratory Syncytial Virus ◽  
Cell Cultures ◽  
Adhesion Molecule ◽  
Critical Role ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Luciferase Reporter ◽  
Intercellular Adhesion Molecule 1 ◽  
Syncytial Virus ◽  
Respiratory Epithelial

ABSTRACT To determine the molecular mechanism(s) of respiratory syncytial virus (RSV)-induced intercellular adhesion molecule-1 (ICAM-1) upregulation in respiratory epithelial cells (REC; A549 cell cultures), we investigated the roles of the transcription factors NF-κB and C/EBP. Increases in ICAM-1 message required de novo mRNA synthesis. ICAM-1 promoter constructs (luciferase reporter gene) transfected into A549 monolayers demonstrated promoter activation following RSV infection. Activation was abolished by site-specific mutation of the NF-κB (−228) or C/EBP (−239) sites. These data support the critical role of the activation of NF-κB and C/EBP in RSV-induced ICAM-1 expression by REC.

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