scholarly journals Dioxin and Estrogen Signaling in Lung Adenocarcinoma Cells with Different Aryl Hydrocarbon Receptor/Estrogen Receptor α Phenotypes

2013 ◽  
Vol 49 (6) ◽  
pp. 1064-1073 ◽  
Author(s):  
Lun-Cheng Kuo ◽  
Li-Chuan Cheng ◽  
Chun-Ju Lin ◽  
Lih-Ann Li
Keyword(s):  
Estrogen Receptor ◽  
Lung Adenocarcinoma ◽  
Aryl Hydrocarbon Receptor ◽  
Estrogen Receptor Α ◽  
Estrogen Signaling ◽  
Aryl Hydrocarbon ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

Aryl Hydrocarbon Receptor is a Target of 17-Allylamino-17-demethoxygeldanamycin and Enhances its Anticancer Activity in Lung Adenocarcinoma Cells

2012 ◽  
Vol 83 (3) ◽  
pp. 605-612 ◽  
Author(s):  
Po-Hung Chen ◽  
Jinghua Tsai Chang ◽  
Lih-Ann Li ◽  
Hui-Ti Tsai ◽  
Mei-Ya Shen ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Aryl Hydrocarbon Receptor ◽  
Anticancer Activity ◽  
Aryl Hydrocarbon ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

scholarly journals Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

2016 ◽  
Vol 437 ◽  
pp. 190-200 ◽  
Author(s):  
Ping Gong ◽  
Zeynep Madak-Erdogan ◽  
Jodi A. Flaws ◽  
David J. Shapiro ◽  
John A. Katzenellenbogen ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Estrogen Receptor Α ◽  
Target Cells ◽  
Aryl Hydrocarbon

scholarly journals Aryl Hydrocarbon Receptor-Mediated Transcription: Ligand-Dependent Recruitment of Estrogen Receptor α to 2,3,7,8-Tetrachlorodibenzo- p-Dioxin-Responsive Promoters

2005 ◽  
Vol 25 (13) ◽  
pp. 5317-5328 ◽  
Author(s):  
Jason Matthews ◽  
Björn Wihlén ◽  
Jane Thomsen ◽  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Rna Polymerase Ii ◽  
Transcriptional Activation ◽  
Time Course ◽  
Estrogen Receptor Α ◽  
Time Dependent ◽  
Promoter Regions ◽  
Aryl Hydrocarbon ◽  
H3 Acetylation

ABSTRACT Using chromatin immunoprecipitation assays, we studied the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated recruitment of the aryl hydrocarbon receptor (AhR) and several coregulators to the CYP1A1 promoter. AhR displayed a time-dependent recruitment, reaching a peak at 75 min and maintaining promoter occupancy for the remainder of the time course. Recruitment of AhR was followed by TIF2/SRC2, which preceded CBP, histone H3 acetylation, and RNA polymerase II (RNAPII). Simultaneous recruitment to the enhancer and the TATA box region suggests the formation of a large multiprotein complex bridging the two promoter regions. Interestingly, estrogen receptor α (ERα) displayed a TCDD- and time-dependent recruitment to the CYP1A1 promoter, which was increased by cotreatment with estradiol. Transfection in HuH7 human liver cells confirmed previously reported ERα enhancement of AhR activity. In contrast, TCDD did not induce the recruitment of ERα to the estrogen-responsive pS2 promoter, and after 120 min of cotreatment with estradiol, ERα is still present on the CYP1A1 promoter but no longer at pS2. RNA interference studies with T47D cells support a role for ERα in TCDD-dependent CYP1A1 expression. Our data suggest that ERα acts as a coregulator of AhR-mediated transcriptional activation and that the recruitment of ERα by AhR represents a novel mechanism AhR-ERα cross talk.

scholarly journals 3-Methylcholanthrene and Other Aryl Hydrocarbon Receptor Agonists Directly Activate Estrogen Receptor α

2006 ◽  
Vol 66 (4) ◽  
pp. 2459-2467 ◽  
Author(s):  
Maen Abdelrahim ◽  
Eric Ariazi ◽  
Kyounghyun Kim ◽  
Shaheen Khan ◽  
Rola Barhoumi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Estrogen Receptor Α ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon
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