Noscapine Loaded PLGA Nanoparticles Prepared Using Oil-in-Water Emulsion Solvent Evaporation Method

2016 ◽  
Vol 3 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Kiran Yadav ◽  
Deepak Yadav ◽  
Manisha Yadav ◽  
Sunil Kumar
Keyword(s):  
Plga Nanoparticles ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Water Emulsion ◽  
Evaporation Method ◽  
Oil In Water ◽  
Oil In Water Emulsion

A Review on Polymeric Nano Micelles Based Delivery to the Posterior Segment of the Eye

2020 ◽  
Vol 10 (5) ◽  
pp. 591-601
Author(s):  
Sheetal Devi ◽  
Shailendra Bhatt ◽  
Vipin Saini ◽  
Manish Kumar ◽  
Aman Deep
Keyword(s):  
Polymeric Micelles ◽  
Drug Loading ◽  
Solvent Evaporation ◽  
Ocular Tissues ◽  
Water Emulsion ◽  
Oil In Water ◽  
Dialysis Method ◽  
Prolonged Retention ◽  
Tear Turnover ◽  
Oil In Water Emulsion

Introduction: Many nanoformulations have been designed and evaluated for ocular drug delivery system consistently. These nanoformulations are designed for prolonged retention and course time, stable, efficient and reversible drug loading. The ocular bioavailability is very less when the drug is given through topically. Various anatomical and physiological limitations, for example, tear turnover, nasal lachrymal waste, reflex squinting, and visual static and dynamic hindrances cause the challenges and delay the ocular drug permeation because of the limitation that less than 5% dose can reach into the ocular tissues. Different types of Polymeric micelles were prepared to overcome the above challenges. Polymeric nano micelles are prepared by different methods, such as direct dissolution, dialysis method, Oil-in-water emulsion, solvent evaporation, co-solvent evaporation, and freeze-drying method.

A Novel Antimicrobial Nano-Composite Porous Material for Bone Repair

2011 ◽  
Vol 695 ◽  
pp. 517-520
Author(s):  
Pei Pei Luo ◽  
Ji Dong Li ◽  
Yi Zuo ◽  
Xia Wu ◽  
Yu Bao Li
Keyword(s):  
Bone Repair ◽  
Drug Loading ◽  
Continuous Phase ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Technological Parameters ◽  
Nano Composite ◽  
Evaporation Method ◽  
Hydrophilic Drugs ◽  
Oil In Water

In this paper, isoniazid (INH)-loaded poly (ε-caprolactone) microspheres with a special microporous surface and relatively high drug loading were fabricated by an oil-in-oil (O/O) solvent evaporation method. Meanwhile the microspheres were produced by an oil-in-water (O/W) method for comparison. The technological parameters such as the concentration of surfactant, the volume of continuous phase and the quantity of the drug were investigated systematically. The microspheres morphology, their size distribution and the viscosity of both the dispersed and continuous phase were characterized. The results indicate that the O/O solvent evaporation method is a feasible approach to encapsulate micromolecular and hydrophilic drugs in PCL. This opens the door for INH-loaded microspheres able to release drugs and thereby improve the therapy of tuberculosis of bones and joints in the future.

scholarly journals Development of size-tunable polymeric nanoparticles for drug delivery applications

2017 ◽  
Vol 1 (2) ◽  
pp. 31 ◽  
Author(s):  
Komkrich Sawasdee ◽  
Ployphailin Choksawad ◽  
Sopida Pimcharoen ◽  
Kanlaya Prapainop
Keyword(s):  
Drug Delivery ◽  
Organic Solvent ◽  
Size Distribution ◽  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Drug Bioavailability ◽  
Evaporation Method ◽  
Drug Delivery Applications

Background:  Poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) have been widely used in drug delivery applications because of its excellent properties such as biocompatibility, biodegradability along with its abilities to deliver hydrophobic drugs, increase drug bioavailability, and improve drug absorption to targeted cells in both oral and parenteral administrations. The PLGA NPs can be synthesized using emulsion solvent evaporation method. Each parameter during synthesis play a role in formation of nanoparticles and could affect to form different NP sizes which is an important factor for successful development of drug delivery system.  Aims: The aim of this study is to prepare different sizes of PLGA NPs by investigation of four factors (molecular weight (MW) of PLGA, emulsifier concentrations, organic solvent type and power of ultrasonication) that involve in PLGA nanoparticle synthesis.Methods: PLGA nanoparticles were prepared by emulsion solvent evaporation method. Size and size distribution were analyzed by dynamic light scattering and polydispersity index (PdI).Results: The effect of four parameters: PLGA MW, emulsifier concentrations, solvent types, and amplitude of ultrasonication on PLGA NPs preparation were evaluated. Changing one parameter results in different sizes of PLGA NPs varied from 150-300 nm. PdI which is an indicator for determination of size distribution of NPs are also varied with overall value less than 0.2.Conclusion: MW of PLGA polymer, emulsifier concentration, type of organic solvent and power of ultrasonication affect the size and size distribution of PLGA NPs. 

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