The Performance of Cemented Femoral Prosthesis Based on New Gel Materials

2020 ◽  
Vol 12 (8) ◽  
pp. 1194-1204
Author(s):  
Daliang Kong ◽  
Chao Du ◽  
Chuangang Peng
Keyword(s):  
Silk Fibroin ◽  
Hip Replacement ◽  
Sem Analysis ◽  
Femoral Prosthesis ◽  
X Ray Diffraction ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
Before And After ◽  
Cement Prosthesis

In view of the problems in hip replacement, a new gel material is developed and incorporated into cemented femoral prosthesis. The material precipitates hydroxyapatite (HA) onto silk fibroin (SF) by biomimetic method, namely silk fibroin hydroxyapatite (SF–HA). Through X-ray diffraction (XRD) and scanning electron microscope (SEM) analysis, HA precipitates on SF. Taking the gel time as the standard, 5 groups of gel materials are selected. Through in vitro degradation experiments, the degradation rate of these materials is 45%∼55%. Cell experiments (mouse L929 cells, osteoblasts HO-F) show that these cells have no cytotoxicity and support the growth of osteoblasts. In addition, in the vivo experiment (two groups), one group was treated with gelatin materials and the other group is treated with bone cement prosthesis transplantation directly. Comparing the indexes before and after operation, it proves that the new gel material has great application value in hip replacement surgery.

scholarly journals Release of Inflammatory Mediators in Association with Collection of Wound Drainage Blood during Orthopaedic Surgery

1995 ◽  
Vol 23 (6) ◽  
pp. 683-686 ◽  
Author(s):  
J. P. Arnold ◽  
M. Haeger ◽  
J. P. Bengtson ◽  
A. Bengtsson ◽  
B. Lisander
Keyword(s):  
Inflammatory Mediators ◽  
Hip Replacement ◽  
Systemic Blood ◽  
Wound Drainage ◽  
Blood Samples ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
Pmn Elastase ◽  
Before And After ◽  
Pmn Élastase

Ten patients undergoing hip replacement surgery were studied regarding activation of complement and leukocytes in association with collection of wound drainage blood. The blood was collected postoperatively but not reinfused due to the possible risks with reinfusion of blood containing inflammatory mediators. Blood samples for analysis of complement activation (TCC), leukocyte activation (PMN elastase) and cytokines (Interleukin-6) were drawn preoperatively from the patients. Blood samples were also drawn intraoperatively from the wound. Samples were also drawn from the collected wound drainage blood, before and after blood was passed through a microporous filter. There were elevated concentrations of TCC, PMN elastase and IL-6 in the collected wound drainage blood before and after the filter. The filtration did not significantly reduce the concentrations of these factors. In the wound blood the concentrations were higher compared to those found in the systemic blood preoperatively, but lower compared to concentrations found in the collected drainage blood. The study demonstrates that the collection of wound drainage whole blood is associated with activation of complement, release of PMN elastase and cytokines.

scholarly journals Marital Relationship and Quality of Life in Couples Following Hip Replacement Surgery

Life ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 401
Author(s):  
Michael Tanzer ◽  
Christopher Pedneault ◽  
Esther Yakobov ◽  
Adam Hart ◽  
Michael Sullivan
Keyword(s):  
Quality Of Life ◽  
Hip Replacement ◽  
Marital Relationship ◽  
Rating Score ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
Before And After ◽  
Numerical Rating ◽  
Patient’S Perception

For the majority of patients with osteoarthritis, total hip (THA) arthroplasty results in a significant reduction in pain, emotional distress, and disability and a significant improvement in their quality of life. Little is known about how these recovery-related changes impact the spouse or the marital relationship. Methods: Twenty-nine couples whose spouse underwent a THA (29 THA) participated in a semi-structured retrospective interview designed for this study. They were each asked to recall the level of pain before and after surgery and to provide a numerical rating score for questions pertaining to the level of disability in seven different activities of daily living. Couples were also asked to list in order of importance the five ways in which the surgery affected their overall quality of life. Results: The spouses estimated their partner’s pain, both pre- and postoperatively, to be significantly higher level than the patient’s perception. The spouses perceived a greater improvement in family/home responsibilities, recreation and social activities, and in their occupation than that noted by the partner. After the arthroplasty, the spouses indicated that their lives had improved with respect to doing more activities/leisure (72%), because their partner had less suffering (59%), they had more independence/less caregiving (55%), it improved their marital relationship (52%), they had a better social/family life (28%), and they were able to travel (28%). Conclusions: This study indicates that THA result in a significant improvement in quality of life not only for the patients, but also for their spouses.

Relationship Between Fibrinogen Proteolysis, Platelet Release And Fibrin Deposition Following Total Hip Replacement

1981 ◽  
Author(s):  
D A Lane ◽  
T G Allen-Mersh ◽  
H Ireland ◽  
S Wolff ◽  
S Jennings ◽  
...  
Keyword(s):  
Hip Replacement ◽  
Thrombus Formation ◽  
Major Surgery ◽  
Fibrin Deposition ◽  
Mean Values ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
Activation Products ◽  
Before And After ◽  
The Mean

It has been postulated that fibrin deposition is controlled by the relative competition of thrombin and plasmin for fibrin I. We have tested this hypothesis by measuring haemostatic activation products in the plasma of patients undergoing hip replacement. Thrombin sensitive fragment fibrinopeptide A (FpA), plasmin sensitive fragment Bβ1-42 and β thromboglobulin (βTG) have been measured before and after operation (n=26). The incidence of venous thrombosis was assessed by phlebography and I125 fibrinogen scanning. The mean preoperative FpA, Bβ1-42 and βTG concentrations were 1.80, 4.22 and 0.99 pmol/ml respectively. The mean FpA and βTG levels rose to 3.07 and 1.56 pmol/ml respectively on the sixth day after operation but the mean Bβ1-42 level rose more rapidly to a maximum of 10.9 pmol/ml on the fourth day after operation. In those patients who developed a thrombosis (n=9), the mean FpA level was higher on the first day after operation (2.83 pmol/ml) than in those patients (n=17) in whom thrombosis did not occur (1.66 pmol/ml). Conversly, the mean Bβ1-42 level was lower (4.76 pmol/ml) in those who developed a thrombus than in those without thrombus (6.79 pmol/ml). When the postoperative day 1 results were expressed as a ratio of FpA/Bβ1-42, the corresponding mean values of this ratio for the two groups of patients were 0.74 and 0.37. These results demonstrate that (a) there is an activation of the coagulation and fibrinolytic systems, and of platelets following hip replacement surgery (b) thrombus formation following major surgery is characterised by an increased action of thrombin on fibrinogen and a reduced action of plasmin on either fibrinogen or fibrin I (c) assays for FpA and Bβ1-42 may be useful for the detection of developing thrombi.

scholarly journals The effects of competition and bundled payment on patient reported outcome measures after hip replacement surgery

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fanny Goude ◽  
Sverre A. C. Kittelsen ◽  
Henrik Malchau ◽  
Maziar Mohaddes ◽  
Clas Rehnberg
Keyword(s):  
Hip Replacement ◽  
Health Gain ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Economic Incentives ◽  
Bundled Payment ◽  
Treatment Groups ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
Patient Reported

Abstract Background Competition-promoting reforms and economic incentives are increasingly being introduced worldwide to improve the performance of healthcare delivery. This study considers such a reform which was initiated in 2009 for elective hip replacement surgery in Stockholm, Sweden. The reform involved patient choice of provider, free establishment of new providers and a bundled payment model. The study aimed to examine its effects on hip replacement surgery quality as captured by patient reported outcome measures (PROMs) of health gain (as indicated by the EQ-5D index and a visual analogue scale (VAS)), pain reduction (VAS) and patient satisfaction (VAS) one and six years after the surgery. Methods Using patient-level data collected from multiple national registers, we applied a quasi-experimental research design. Data were collected for elective primary total hip replacements that were carried out between 2008 and 2012, and contain information on patient demography, the surgery and PROMs at baseline and at one- and six-years follow-up. In total, 36,627 observations were included in the analysis. First, entropy balancing was applied in order to reduce differences in observable characteristics between treatment groups. Second, difference-in-difference analyses were conducted to eliminate unobserved time-invariant differences between treatment groups and to estimate the causal treatment effects. Results The entropy balancing was successful in creating balance in all covariates between treatment groups. No significant effects of the reform were found on any of the included PROMs at one- and six-years follow-up. The sensitivity analyses showed that the results were robust. Conclusions Competition and bundled payment had no effects on the quality of hip replacement surgery as captured by post-surgery PROMs of health gain, pain reduction and patient satisfaction. The study provides important insights to the limited knowledge on the effects of competition and economic incentives on PROMs.

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