scholarly journals Effects of training to perform a working memory Task on regular spiking and fast spiking neurons in the lateral prefrontal cortex

2010 ◽  
Vol 9 (8) ◽  
pp. 577-577
Author(s):  
X. Qi ◽  
T. Meyer ◽  
C. Constantinidis
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Memory Task ◽  
Spiking Neurons ◽  
Lateral Prefrontal Cortex ◽  
Fast Spiking

scholarly journals Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks

2021 ◽  
Author(s):  
Megan Roussy ◽  
Rogelio Luna ◽  
Lyndon Duong ◽  
Benjamin Corrigan ◽  
Roberto A. Gulli ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Memory Deficits ◽  
Lateral Prefrontal Cortex ◽  
Neuronal Populations ◽  
Neuronal Types ◽  
Fast Spiking ◽  
Selective Working

AbstractKetamine is a dissociative anesthetic drug, which has more recently emerged as a rapid-acting antidepressant. When acutely administered at subanesthetic doses, ketamine causes cognitive deficits like those observed in patients with schizophrenia, including impaired working memory. Although these effects have been linked to ketamine’s action as an N-methyl-D-aspartate receptor antagonist, it is unclear how synaptic alterations translate into changes in brain microcircuit function that ultimately influence cognition. Here, we administered ketamine to rhesus monkeys during a spatial working memory task set in a naturalistic virtual environment. Ketamine induced transient working memory deficits while sparing perceptual and motor skills. Working memory deficits were accompanied by decreased responses of fast spiking inhibitory interneurons and increased responses of broad spiking excitatory neurons in the lateral prefrontal cortex. This translated into a decrease in neuronal tuning and information encoded by neuronal populations about remembered locations. Our results demonstrate that ketamine differentially affects neuronal types in the neocortex; thus, it perturbs the excitation inhibition balance within prefrontal microcircuits and ultimately leads to selective working memory deficits.

scholarly journals Conjunctive representation of what and when in monkey hippocampus and lateral prefrontal cortex during an associative memory task

2019 ◽  
Author(s):  
Nathanael A. Cruzado ◽  
Zoran Tiganj ◽  
Scott L. Brincat ◽  
Earl K. Miller ◽  
Marc W. Howard
Keyword(s):  
Prefrontal Cortex ◽  
Associative Memory ◽  
Memory Task ◽  
Neural Recording ◽  
Temporal Coding ◽  
Adaptive Memory ◽  
Lateral Prefrontal Cortex ◽  
The Past ◽  
Large Numbers

AbstractAdaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the monkey to associate stimuli separated by about a second in time. After the first stimulus was presented, large numbers of units in both HPC and PFC fired in sequence. Many units fired only when a particular stimulus was presented at a particular time in the past. These results indicate that both HPC and PFC maintain a temporal record of events that could be used to form associations across time. This temporal record of the past is a key component of the temporal coding hypothesis, a hypothesis in psychology that memory not only encodes what happened, but when it happened.

scholarly journals Prefrontal and Parietal Attractor Networks Mediate Working Memory Judgments

2020 ◽  
Author(s):  
Sihai Li ◽  
Christos Constantinidis ◽  
Xue-Lian Qi
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Critical Role ◽  
Memory Task ◽  
Delayed Response ◽  
Persistent Activity ◽  
Neural Basis ◽  
Brain Areas ◽  
Dorsolateral Prefrontal

ABSTRACTThe dorsolateral prefrontal cortex plays a critical role in spatial working memory and its activity predicts behavioral responses in delayed response tasks. Here we addressed whether this predictive ability extends to categorical judgments based on information retained in working memory, and is present in other brain areas. We trained monkeys in a novel, Match-Stay, Nonmatch-Go task, which required them to observe two stimuli presented in sequence with an intervening delay period between them. If the two stimuli were different, the monkeys had to saccade to the location of the second stimulus; if they were the same, they held fixation. Neurophysiological recordings were performed in areas 8a and 46 of the dlPFC and 7a and lateral intraparietal cortex (LIP) of the PPC. We hypothesized that random drifts causing the peak activity of the network to move away from the first stimulus location and towards the location of the second stimulus would result in categorical errors. Indeed, for both areas, when the first stimulus appeared in a neuron’s preferred location, the neuron showed significantly higher firing rates in correct than in error trials. When the first stimulus appeared at a nonpreferred location and the second stimulus at a preferred, activity in error trials was higher than in correct. The results indicate that the activity of both dlPFC and PPC neurons is predictive of categorical judgments of information maintained in working memory, and the magnitude of neuronal firing rate deviations is revealing of the contents of working memory as it determines performance.SIGNIFICANCE STATEMENTThe neural basis of working memory and the areas mediating this function is a topic of controversy. Persistent activity in the prefrontal cortex has traditionally been thought to be the neural correlate of working memory, however recent studies have proposed alternative mechanisms and brain areas. Here we show that persistent activity in both the dorsolateral prefrontal cortex and posterior parietal cortex predicts behavior in a working memory task that requires a categorical judgement. Our results offer support to the idea that a network of neurons in both areas act as an attractor network that maintains information in working memory, which informs behavior.

Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI

1994 ◽  
Vol 1 (4) ◽  
pp. 293-304 ◽  
Author(s):  
Jonathan D. Cohen ◽  
Steven D. Forman ◽  
Todd S. Braver ◽  
B. J. Casey ◽  
David Servan-Schreiber ◽  
...  
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Functional Mri ◽  
Memory Task

Neural Ensemble Coding during Working Memory Task in Rat Prefrontal Cortex

2011 ◽  
Vol 467-469 ◽  
pp. 1291-1296
Author(s):  
Wen Wen Bai ◽  
Xin Tian
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Firing Rate ◽  
Memory Task ◽  
Neural Population ◽  
Average Firing Rate ◽  
Population Activity ◽  
Ensemble Coding ◽  
Neural Ensemble ◽  
Ensemble Activity

Working memory is one of important cognitive functions and recent studies demonstrate that prefrontal cortex plays an important role in working memory. But the issue that how neural activity encodes during working memory task is still a question that lies at the heart of cognitive neuroscience. The aim of this study is to investigate neural ensemble coding mechanism via average firing rate during working memory task. Neural population activity was measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Y-maze. Then the original data was filtered by a high-pass filtering, spike detection and spike sorting, spatio-temporal trains of neural population were ultimately obtained. Then, the average firing rates were computed in a selected window (500ms) with a moving step (125ms). The results showed that the average firing rate were higher during workinig memory task, along with obvious ensemble activity. Conclusion: The results indicate that the working memory information is encoded with neural ensemble activity.

scholarly journals Compressed Timeline of Recent Experience in Monkey Lateral Prefrontal Cortex

2018 ◽  
Vol 30 (7) ◽  
pp. 935-950 ◽  
Author(s):  
Zoran Tiganj ◽  
Jason A. Cromer ◽  
Jefferson E. Roy ◽  
Earl K. Miller ◽  
Marc W. Howard
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Sample Stimulus ◽  
Human Memory ◽  
Recent Experience ◽  
Lateral Prefrontal Cortex ◽  
Elapsed Time ◽  
Cognitive Theories ◽  
Stimulus Identity ◽  
Neural Underpinnings

Cognitive theories suggest that working memory maintains not only the identity of recently presented stimuli but also a sense of the elapsed time since the stimuli were presented. Previous studies of the neural underpinnings of working memory have focused on sustained firing, which can account for maintenance of the stimulus identity, but not for representation of the elapsed time. We analyzed single-unit recordings from the lateral prefrontal cortex of macaque monkeys during performance of a delayed match-to-category task. Each sample stimulus triggered a consistent sequence of neurons, with each neuron in the sequence firing during a circumscribed period. These sequences of neurons encoded both stimulus identity and elapsed time. The encoding of elapsed time became less precise as the sample stimulus receded into the past. These findings suggest that working memory includes a compressed timeline of what happened when, consistent with long-standing cognitive theories of human memory.

Sign in / Sign up

Export Citation Format

Share Document