scholarly journals MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect

2015 ◽  
Vol 56 (9) ◽  
pp. 5450 ◽  
Author(s):  
Kyu-Yeon Han ◽  
Jennifer Dugas-Ford ◽  
Hyun Lee ◽  
Jin-Hong Chang ◽  
Dimitri T. Azar
Keyword(s):  
Antiangiogenic Effect ◽  
Vegf Trap

scholarly journals In Vitro Pharmaco-Toxicological Characterization of Melissa officinalis Total Extract Using Oral, Pharynx and Colorectal Carcinoma Cell Lines

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 850
Author(s):  
Kristine Guran ◽  
Roxana Buzatu ◽  
Iulia Pinzaru ◽  
Madalina Boruga ◽  
Iasmina Marcovici ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Melissa Officinalis ◽  
Pharmacological Profile ◽  
In Ovo ◽  
Total Extract ◽  
Antiangiogenic Effect ◽  
Beneficial Effects ◽  
Gram Positive Bacteria ◽  
Potential Benefits

Melissa officinalis is a medicinal herb with an extensive pharmacological profile that has been proven to have beneficial effects in oral and gastrointestinal disorders. However, the effects of this plant in oral, pharyngeal, and colorectal malignancies, types of cancer with an increased incidence in recent years, are less investigated. The present study aims to evaluate the pharmacological profile of a Melissa officinalis total extract for potential benefits in oral, pharynx and colorectal carcinoma. The LC-MS profile of MO total extract (MOte) indicated a rich content in polyphenols, data that support the potent antioxidant capacity exhibited and the antimicrobial activity against both Gram-negative and Gram-positive bacteria. In addition, MOte triggered a dose-dependent and selective decrease in the viability of tumor cells (tongue and pharynx squamous cell carcinomas, and colorectal adenocarcinoma), with the most significant effect being recorded at 100 µg/mL. At the same concentration, MOte exhibited an antiangiogenic effect by inhibiting the process of angiogenesis in ovo. Overall, our findings support the potential benefits of Melissa officinalis leaf total extract as a valuable candidate for the prophylaxis of oral, pharyngeal and colorectal neoplasms.

scholarly journals Inhibition of AngiogenesisIn Vitroby Chebulagic Acid: A COX-LOX Dual Inhibitor

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
A. P. Athira ◽  
A. Helen ◽  
K. Saja ◽  
P. Reddanna ◽  
P. R. Sudhakaran
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Model Systems ◽  
Antiangiogenic Effect ◽  
Dual Inhibitor ◽  
Endogenous Factors ◽  
Human Umbilical Vein ◽  
Chebulagic Acid ◽  
Vessel Growth ◽  
Umbilical Vein Endothelial Cells

Angiogenesis is a crucial step in the growth of cancer and its metastasis. It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth. Besides these endogenous factors, several exogenous factors including some natural compounds are known to modulate angiogenesis. Angiogenesis being a potential target for drugs against a number of pathological conditions, search for compounds from natural sources that can affect angiogenesis is of great interest. The objective of our present study was to understand the effect of chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits ofTerminalia chebulaRetz., on angiogenesis. The model systems used were rat aortic rings and human umbilical vein endothelial cells. The results showed that chebulagic acid exerts an antiangiogenic effect. This was evidenced from decreased sprouting in rat aortic rings and decrease in biochemical markers in endothelial cells treated with chebulagic acid. It downregulated the production of CD31, E-selectin, and vascular endothelial growth factor in human umbilical vein endothelial cells in culture (HUVEC). Further studies to understand the molecular mechanism of action of chebulagic acid revealed that CA exerts its anti angiogenic effect by modulating VE cadherin-βcatenin signalling in human umbilical vein endothelial cells.

VEGF-PATHWAY IS INVOLVED IN ANTI-TUMOUR AND ANTIANGIOGENIC EFFECT OF ARGININE DEIMINASE ON RENAL CELL CARCINOMA

2006 ◽  
Vol 5 (2) ◽  
pp. 29
Author(s):  
C.Y. Yoon ◽  
D.H. Yoon ◽  
Y.J. Shim ◽  
E.H. Kim ◽  
K.Y. Chae ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Arginine Deiminase ◽  
Antiangiogenic Effect ◽  
Vegf Pathway

scholarly journals Effect of VEGF Trap on Normal Retinal Vascular Development and Oxygen-Induced Retinopathy in the Dog

2011 ◽  
Vol 52 (7) ◽  
pp. 4039 ◽  
Author(s):  
Gerard A. Lutty ◽  
D. Scott McLeod ◽  
Imran Bhutto ◽  
Stanley J. Wiegand
Keyword(s):  
Vascular Development ◽  
Oxygen Induced Retinopathy ◽  
Vegf Trap

Isopimpinellin extends antiangiogenic effect through overexpression of miR-15b-5p and downregulating angiogenic stimulators

2021 ◽  
Author(s):  
Sambhavi Bhagavatheeswaran ◽  
Vinu Ramachandran ◽  
Sambantham Shanmugam ◽  
Anandan Balakrishnan
Keyword(s):  
Antiangiogenic Effect

Investigating the Anti-Angiogenic Effects of Elaeagnus angustifolia L. Extract in Vivo

2021 ◽  
Vol 08 ◽  
Author(s):  
Mohammad Sako ◽  
Malek Zihlif ◽  
Fatma Afifi
Keyword(s):  
Blood Vessels ◽  
Cell Line ◽  
A549 Cells ◽  
Water Extract ◽  
Elaeagnus Angustifolia ◽  
Trypan Blue Exclusion ◽  
Antiangiogenic Effect ◽  
Proliferative Effect ◽  
Fgf2 Expression

Background: Angiogenesis is the formation of new blood vessels from pre-existing ones. It occurs in both physiological and pathological conditions. Objectives: We aimed to evaluate the antiangiogenic effect of Elaeagnus angustifolia L. water extract in vivo to determine any anti-proliferative effect of the extract on the A549 lung cancer cell line, and to investigate its effect on VEGF-A and FGF2 expression in the A549 cell line. Methods: Trypan blue exclusion test was implemented to establish any possible anti-proliferative effect of the extract. Then, Matrigel plug assay was performed on mice using the same cell line to test the antiangiogenic effect of the extract. Finally, A549 cells were treated with the extract at concentrations of 25, 12.5, and 6.25 µg/ml to investigate the changes in VEGF-A and FGF2 expression by RT-qPCR. Results: E. angustifolia extract did not exhibit a significant anti-proliferative effect against A549 cells. The extract at concentrations of 12.5 and 6.25 µg/ml demonstrated an inhibitory effect against the growth of new blood vessels by 75.63 and 45.26%, respectively. The extract did not affect the expression of VEGF-A and FGF2 in A549 cells. Conclusion: Our findings show that water extract of E. angustifolia possesses potent antiangiogenic activity, while neither exhibiting significant anti-proliferative effect nor affecting VEGF-A or FGF2 expression in the A459 cell line, suggesting either sole direct antiangiogenic effect, or both direct and indirect effects with paracrine suppression of other genes.

The systemic antiangiogenic effect of intravitreal aflibercept injection in a mouse model of retinopathy of prematurity

2021 ◽  
Vol 35 (3) ◽  
Author(s):  
Yusuke Ichiyama ◽  
Shumpei Obata ◽  
Yoshitsugu Saishin ◽  
Osamu Sawada ◽  
Masashi Kakinoki ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinopathy Of Prematurity ◽  
Antiangiogenic Effect ◽  
Intravitreal Aflibercept
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