The Impact of Conjunctivochalasis on Dry Eye Symptoms and Signs

Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD).Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment.Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P < 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P < 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P < 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P < 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P < 0.05).Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality.

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Dry eye symptoms and signs in children wearing OK lenses for six months in China

Journal Français d Ophtalmologie ◽

10.1016/j.jfo.2019.07.029 ◽

2020 ◽

Vol 43 (3) ◽

pp. 211-215

Author(s):

Z.P. Yan

Keyword(s):

Dry Eye ◽

Eye Symptoms ◽

Symptoms And Signs ◽

Dry Eye Symptoms

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Leptin’s concentration in tears and dry eye: a clinical observational study

International Journal of Ophthalmology ◽

10.18240/ijo.2021.01.12 ◽

2021 ◽

Vol 14 (1) ◽

pp. 83-88

Author(s):

Ran Hao ◽

◽

Xue-Min Li ◽

Keyword(s):

Dry Eye ◽

Linear Regression Analysis ◽

Multivariate Linear Regression Analysis ◽

Ocular Surface Disease Index ◽

Fluorescein Staining ◽

Significant Difference ◽

Eye Symptoms ◽

Tear Meniscus Height ◽

Symptoms And Signs ◽

Dry Eye Symptoms

AIM: To investigate the concentration of leptin in tears and its correlation with dry eye symptoms and signs. METHODS: The study enrolled individuals (n=39) responding to an advertising or dry eye patients (n=58) from the Ophthalmology Department. Tear samples were collected for leptin concentration measuring. Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear break up time (TBUT), cornea fluorescein staining, Schirmer test (ST) and impression cytology (IC) were assessed. Leptin concentration in tears of dry eye patients and healthy controls, and its correlation with clinical features of dry eye disease (DED) were analyzed. RESULTS: Age, body mass index (BMI), OSDI scores and cornea fluorescein staining scores showed a negative correlation with leptin concentration in tears (r=-0.340, P=0.001; r=-0.332, P=0.001; r=-0.258, P=0.011; r=-0.424, P<0.001, respectively). ST showed positive correlation with leptin concentration in tears (r=0.206, P=0.045). No significant difference was observed in leptin concentration between dry eye patients and controls (P=0.682). Multivariate linear regression analysis revealed that dry eye, OSDI, corneal fluorescein staining scores and ST correlated with leptin concentration in tears. CONCLUSION: This is the first study measuring leptin concentration in tears. The correlation between leptin concentration and DED symptoms and signs reveal that leptin level correlated with the dry eye, potentially contributing to repair of ocular damage and dry eye improvement.

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Impact of Prolonged Face Mask Wearing On Tear Break-Up Time and Dry Eye Symptoms in Health Care Professionals

10.21203/rs.3.rs-886517/v1 ◽

2021 ◽

Author(s):

Mine Esen Baris ◽

Suzan Guven Yilmaz ◽

Melis Palamar

Keyword(s):

Health Care ◽

Dry Eye ◽

Health Care Professionals ◽

Face Mask ◽

Ophthalmological Examination ◽

Eye Symptoms ◽

The Mean ◽

Break Up ◽

The Impact ◽

Dry Eye Symptoms

Abstract Purpose To evaluate the impact of prolonged surgical face mask wearing on dry eye symptoms and tear film break-up time (T-BUT) in health care professionals. Materials and Methods A total of 33 health care professionals were included in this cross sectional, prospective study. T-BUT measurements were performed twice for all participants in the morning (8 am) and in the afternoon (5 pm) in addition to a complete ophthalmological examination. The subjects also filled-in the ocular surface disease index (OSDI) questionnaire twice, before and after wearing the face mask, on the same day. Results Sixty six eyes of 33 participants (17 female and 16 male) were evaluated. The mean age was 33.6 ± 7.55 (24–48) years and mean total duration with mask on between the two evaluations was 514 ± 12.5 (495–526) minutes. The mean T-BUT was 9.3 ± 1.0 (3–16) seconds at 8 am and 8.3 ± 1.5 (3–14) seconds at 5 pm (p = 0.01). The mean OSDI score was 20.1 ± 8.3 (0-68.75) at 8 am and 27.4 ± 10.4 (0-81.25) at 5 pm (p < 0.01). Conclusion Use of a surgical mask for the entire work day was seen to worsen T-BUT and dry eye symptoms in healthy individuals. Ophthalmologists should be aware of possible worsening of condition in patients with dry eye with the prolonged use of face masks and consider modifications if necessary.

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Dry eye symptoms and signs in US veterans with Gulf War Illness

American Journal of Ophthalmology ◽

10.1016/j.ajo.2021.11.010 ◽

2021 ◽

Author(s):

Victor Sanchez ◽

Brandon S. Baksh ◽

Kimberly Cabrera ◽

Anjalee Choudhury ◽

Katherine Jensen ◽

...

Keyword(s):

Dry Eye ◽

Gulf War ◽

Gulf War Illness ◽

Eye Symptoms ◽

Us Veterans ◽

Symptoms And Signs ◽

Dry Eye Symptoms

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An evaluation of dry eye symptoms and signs in a cohort of children with juvenile idiopathic arthritis

Clinical Ophthalmology ◽

10.2147/opth.s4916 ◽

2009 ◽

pp. 271 ◽

Cited By ~ 6

Author(s):

Kaisu Kotaniemi ◽

Kristiina Sihto-Kauppi ◽

Salomaa Pirjo ◽

Hanna Saila ◽

Kauppi Markku

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Dry Eye ◽

Eye Symptoms ◽

Symptoms And Signs ◽

Dry Eye Symptoms

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Relationships between activated dendritic cells and dry eye symptoms and signs

The Ocular Surface ◽

10.1016/j.jtos.2021.06.001 ◽

2021 ◽

Author(s):

Harry Levine ◽

Jodi Hwang ◽

Harrison Dermer ◽

Divy Mehra ◽

William Feuer ◽

...

Keyword(s):

Dendritic Cells ◽

Dry Eye ◽

Eye Symptoms ◽

Symptoms And Signs ◽

Dry Eye Symptoms

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Provocation of Dry Eye Disease during COVID-19 Lockdown

10.21203/rs.3.rs-858036/v1 ◽

2021 ◽

Author(s):

Nutnicha Neti ◽

Pinnita Prabhasawat ◽

Chareenun Chirapapaisan ◽

Panotsom Ngowyutagon

Keyword(s):

Mental Health ◽

Health Status ◽

Dry Eye ◽

Dry Eye Disease ◽

Mental Health Status ◽

Eye Disease ◽

Eye Symptoms ◽

The Mean ◽

The Impact ◽

Dry Eye Symptoms

Abstract To assess the impact of COVID-19 lockdown measures on dry-eye symptoms in a community-based population, a cross-sectional study was conducted during the first wave of the COVID-19 outbreak in Thailand. An online survey was distributed via social media between June and July 2020. The questionnaire elicited information on demographics, dry-eye symptoms, viewing habits, and mental health status. There were 535 respondents. Thirty-seven percent reported having been diagnosed with dry-eye disease (DED). During the lockdown, the mean dry-eye symptom score (DESS) of overall participants dropped significantly from 81.6±15.9 to 79.8±17.4 (P<0.001). The mean, daily, visual display terminal (VDT) usage increased from 10.55±5.16 hours to 13.08±5.65 hours (P<0.001). A negative correlation between age and VDT usage was observed in both the normal and lockdown situations. One-quarter of all participants had an abnormal mental health status. The female gender (OR 1.86; 95% CI 1.14–3.04) and increased VDT usage during the lockdown (OR 5.68; 95% CI 3.49–9.23) were independently associated with worsening dry-eye symptoms. The lockdown measures abruptly altered the behaviors and lifestyles of the overall population. Excessive exposure to VDTs were associated with deteriorated dry-eye symptoms, and it possibly contributed to the increased DED incidence in the general population.

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