Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement

Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD).Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment.Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P < 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P < 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P < 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P < 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P < 0.05).Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality.

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Meibomian gland dysfunction is the primary determinant of dry eye symptoms: Analysis of 2346 patients

The Ocular Surface ◽

10.1016/j.jtos.2020.06.008 ◽

2020 ◽

Vol 18 (4) ◽

pp. 604-612 ◽

Cited By ~ 2

Author(s):

Calesta Hui Yi Teo ◽

Hon Shing Ong ◽

Yu-Chi Liu ◽

Louis Tong

Keyword(s):

Dry Eye ◽

Meibomian Gland ◽

Meibomian Gland Dysfunction ◽

Primary Determinant ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Treatment for meibomian gland dysfunction and dry eye symptoms with a single-dose vectored thermal pulsation

Current Opinion in Ophthalmology ◽

10.1097/icu.0000000000000165 ◽

2015 ◽

Vol 26 (4) ◽

pp. 306-313 ◽

Cited By ~ 14

Author(s):

Caroline A. Blackie ◽

Alan N. Carlson ◽

Donald R. Korb

Keyword(s):

Single Dose ◽

Dry Eye ◽

Meibomian Gland ◽

Meibomian Gland Dysfunction ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Effects of dietary high dose DHA omega-3 supplement in dry eye with meibomian gland dysfunction

International Journal of Ophthalmology ◽

10.18240/ijo.2021.11.08 ◽

2021 ◽

Vol 14 (11) ◽

pp. 1700-1706

Author(s):

Yeon Ji Jo ◽

Keyword(s):

Placebo Group ◽

Dietary Supplement ◽

Dry Eye ◽

Tear Film ◽

Meibomian Gland ◽

Meibomian Gland Dysfunction ◽

Controlled Clinical Trial ◽

High Dose ◽

Omega 3 ◽

Ocular Surface Disease Index

AIM: To evaluate the clinical efficacy of dietary supplement of high dose DHA omega-3 in dry eye with meibomian gland dysfunction (MGD). METHODS: Prospective randomized double-masked, placebo-controlled clinical trial was conducted in mild to moderate dry eye patients with MGD. Patients have no history of taking any dietary omega-3 supplements before 3mo. Patients were divided into two groups: 24 patients in the omega-3 group and 26 patients in the placebo group. The omega-3 group received two capsules of Easyeye Dry®, total containing 600 mg of EPA and 1640 mg of DHA, while the placebo group received two capsules containing 3000 mg of olive oil. All patients take two pills once a day. The examination of MGD scores, tear break-up time (TBUT), corneal staining test (NEI), strip meniscometry (SM tube), and ocular surface disease index (OSDI) scores were performed at baseline, after 4 and 8wk. RESULTS: A total of 50 patients were included. There were no differences in baseline characteristics between the two groups, such as age, sex, and other ocular examination findings. The TBUT, NEI, and OSDI scores significantly improved after 4 and 8wk in both groups. While after 8wk TBUT (6.00±1.62s vs 5.08±1.28s, P=0.034) and MGD score (7.2±1.8 vs 8.1±2.6, P=0.033) in the omega-3 group was more significantly improved than that of the placebo group. CONCLUSION: Dry eye with the MGD patient, a high dose of DHA omega-3 dietary supplement can improve TBUT and MGD score after 8wk, effective in stabilizing the tear film.

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TEAR FILM EVALUATION IN CASES OF PARKINSON’S DISEASE

10.36106/ijar/8503716 ◽

2021 ◽

pp. 22-24

Author(s):

V. Meenakshi ◽

Saswathi Bhushan ◽

T. Jyothirmayi

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Dry Eye ◽

Meibomian Gland ◽

Blink Rate ◽

Eye Symptoms ◽

Tear Meniscus ◽

Tear Meniscus Height ◽

Dry Eye Symptoms ◽

Meibomian Gland Disease

AIM: To evaluate tear lm status in cases of Parkinson's Disease and compare with a study group METHODS:50 patients of Parkinson's Disease and 50 age-gender matched controls were included in this study. Both groups underwent detailed history regarding dry eye symptoms,tear lm evaluation using slit-lamp bio-microscopy, uorescein staining, tear meniscus height, tear breakup time, Schirmer test, blink rate. Statistical analysis was done with Statistical Package for Social Sciences [SPSS] - Version 22.0 Released 2013 version RESULTS: There was a signicant difference between the various groups in terms of distribution of Meibomian Gland Disease 72.0% of the Case group as compared to 40% of control group had Meibomian Gland Disease,There was a signicant difference between the various groups in terms of distribution of Tear Meniscus Height <0.25Mm , Case group had the larger proportion of Tear Meniscus Height of <0.25Mm .There was a signicant difference between the various groups in terms of distribution of Tear Breakup Time <5 Sec, Schirmer's Test <5Mm in 5Min and Blink Rate <10 .There was no signicant difference between the various groups in terms of distribution of corneal Staining and dry eye symptoms. CONCLUSION: The study concluded that patient of Parkinson's disease had higher dry eye symptoms and Meibomian gland disease Also they have reduced Tear miniscus height,Tear lm break up time,Schirmer test I and Blink rate

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Association of tear proteins with Meibomian gland disease and dry eye symptoms

British Journal of Ophthalmology ◽

10.1136/bjo.2010.185256 ◽

2010 ◽

Vol 95 (6) ◽

pp. 848-852 ◽

Cited By ~ 54

Author(s):

L. Tong ◽

L. Zhou ◽

R. W. Beuerman ◽

S. Z. Zhao ◽

X. R. Li

Keyword(s):

Dry Eye ◽

Meibomian Gland ◽

Tear Proteins ◽

Eye Symptoms ◽

Dry Eye Symptoms ◽

Meibomian Gland Disease

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Objective assessment of meibomian gland drop out and its relationship with dry eye symptoms

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2018.04.196 ◽

2018 ◽

Vol 41 ◽

pp. S35-S36

Author(s):

Carolina Kunnen ◽

Percy Lazon de la Jara ◽

Brien Holden ◽

Eric Papas

Keyword(s):

Dry Eye ◽

Objective Assessment ◽

Meibomian Gland ◽

Drop Out ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications

International Journal of Ophthalmology ◽

10.18240/ijo.2021.06.18 ◽

2021 ◽

Vol 14 (6) ◽

pp. 915-922

Author(s):

Li-Xiang Wang ◽

Keyword(s):

Tear Film ◽

Meibomian Gland ◽

The Body ◽

Meibomian Gland Dysfunction ◽

Evidence Based ◽

Lipid Layer ◽

Normal Functions ◽

Potential Applications ◽

Eye Symptoms ◽

Dry Eye Symptoms

Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation. The loss of normal functions of meibomian gland, known as meibomian gland dysfunction (MGD), is a chronic disease and is the leading cause of dry eye symptoms in the clinics. Studies have found sex hormones, especially androgen, play vital roles in the regulation of the functions of meibomian gland. Recently, androgen has also been preliminarily applied in clinics for the treatment of MGD and showed promising results, especially in people with endogenous androgen deficiency. This review summarized the mechanisms of the function of androgen on meibomian gland based on molecular, animal, and clinical studies, and proposed evidence-based views about its potential applications for the treatment of MGD.

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Investigation of Meibomian Gland Function and Dry Eye Disease in Patients with Graves’ Ophthalmopathy

Journal of Clinical Medicine ◽

10.3390/jcm9092814 ◽

2020 ◽

Vol 9 (9) ◽

pp. 2814

Author(s):

Sachiko Inoue ◽

Motoko Kawashima ◽

Reiko Arita ◽

Ai Kozaki ◽

Kazuo Tsubota

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Normal Subjects ◽

Meibomian Gland ◽

Clinical Activity ◽

Upper Eyelid ◽

Graves Ophthalmopathy ◽

Related Quality ◽

Eye Symptoms ◽

Dry Eye Symptoms

We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves’ ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonance imaging (MRI). Ocular surface examinations included fluorescein staining for keratoconjunctival epithelial damage, tear breakup time (TBUT) evaluation, and Schirmer’s test. Dry eye symptoms were evaluated with the Dry Eye-related Quality-of-Life Score (DEQS) questionnaire. Lid-margin abnormalities, meibum grade, and meiboscores were assessed using meibography. Clinical activity scores and T2 signal intensity ratios were used to define GO activity. All GO patients had obstructive MGD and 79% exhibited levator muscle enlargement. Ocular surface parameters of TBUT (p = 0.000), meibum score (p = 0.000), eyelid vasculitis (p = 0.000), meiboscore of the upper lid (p = 0.002), total meiboscores (p = 0.001), and DEQS (p = 0.000) significantly differed between GO patients and normal subjects. In addition, GO patients had significantly more abnormalities of the central region of the upper eyelid than normal subjects (p = 0.000). Thus, MGD might be related to eye discomfort and deterioration of the ocular surface in GO patients. Inflammation and morphological meibomian gland changes might be characteristic of GO.

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