scholarly journals Leptin’s concentration in tears and dry eye: a clinical observational study

2021 ◽  
Vol 14 (1) ◽  
pp. 83-88
Author(s):  
Ran Hao ◽  
◽  
Xue-Min Li ◽  
Keyword(s):  
Dry Eye ◽  
Linear Regression Analysis ◽  
Multivariate Linear Regression Analysis ◽  
Ocular Surface Disease Index ◽  
Fluorescein Staining ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Tear Meniscus Height ◽  
Symptoms And Signs ◽  
Dry Eye Symptoms

AIM: To investigate the concentration of leptin in tears and its correlation with dry eye symptoms and signs. METHODS: The study enrolled individuals (n=39) responding to an advertising or dry eye patients (n=58) from the Ophthalmology Department. Tear samples were collected for leptin concentration measuring. Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear break up time (TBUT), cornea fluorescein staining, Schirmer test (ST) and impression cytology (IC) were assessed. Leptin concentration in tears of dry eye patients and healthy controls, and its correlation with clinical features of dry eye disease (DED) were analyzed. RESULTS: Age, body mass index (BMI), OSDI scores and cornea fluorescein staining scores showed a negative correlation with leptin concentration in tears (r=-0.340, P=0.001; r=-0.332, P=0.001; r=-0.258, P=0.011; r=-0.424, P<0.001, respectively). ST showed positive correlation with leptin concentration in tears (r=0.206, P=0.045). No significant difference was observed in leptin concentration between dry eye patients and controls (P=0.682). Multivariate linear regression analysis revealed that dry eye, OSDI, corneal fluorescein staining scores and ST correlated with leptin concentration in tears. CONCLUSION: This is the first study measuring leptin concentration in tears. The correlation between leptin concentration and DED symptoms and signs reveal that leptin level correlated with the dry eye, potentially contributing to repair of ocular damage and dry eye improvement.

scholarly journals Comparable effects on tear film parameters after femtosecond laser-assisted and conventional cataract surgery

2020 ◽  
Vol 40 (11) ◽  
pp. 3097-3104 ◽  
Author(s):  
Marc Schargus ◽  
Svetlana Ivanova ◽  
Gesa Stute ◽  
H. Burkhard Dick ◽  
Stephanie C. Joachim
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Surgical Techniques ◽  
Tear Film ◽  
Schirmer Test ◽  
Fluorescein Staining ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Abstract Purpose Dry eye symptoms after conventional cataract surgery are a very common problem. Until now, only few data are available on objective tear film parameters in regard to femtosecond laser-assisted cataract surgery (LCS). Aim of this study was therefore to analyze and compare tear film parameter changes between LCS and conventional cataract surgery. Methods A consecutive group of 34 patients, scheduled for cataract surgery, were randomly selected for either LCS or conventional cataract surgery (17 patients/group). Tear film assessments including tear film osmolarity, Schirmer test, MMP-9 analysis via quantitative ELISA, corneal sensitivity, corneal fluorescein staining, and conjunctival fluorescein staining were sequentially evaluated pre- as well as 1 and 3 months postoperatively. Results Both groups showed no significant difference in baseline characteristics. All surgeries were performed without any complications. After 1 and 3 months, there was no statistically significant difference in regard to tear film osmolarity (1 month: p = 0.81, 3 months: p = 1.0), Schirmer test (1 month: p = 0.35, 3 month: p = 0.08), and MMP-9 concentration (1 month: p = 0.36, 3 month: p = 0.28) between the two groups. Conclusions Neither LCS nor conventional cataract surgery affected objective tear film parameters significantly during our 3-month postoperative observation period. Hence, both surgical techniques can be equally used to treat patients without prior dry eye symptoms.

scholarly journals The Association between Preoperative Dry Eye Symptoms and Postoperative Discomfort in Patients Underwent Photorefractive Keratectomy

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Gilad Rabina ◽  
Ingibjorg Iris Boguslavsky ◽  
Michael Mimouni ◽  
Igor Kaiserman
Keyword(s):  
Postoperative Pain ◽  
Dry Eye ◽  
Subjective Evaluation ◽  
Case Series ◽  
Photorefractive Keratectomy ◽  
Ocular Surface Disease Index ◽  
Retrospective Case ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Purpose. To investigate the association between preoperative dry eye symptoms on postoperative pain and discomfort after photorefractive keratectomy (PRK). Methods. A retrospective case series of 151 consecutive patients, who underwent myopic PRK in both eyes between 5/2016 and 5/2017. Patients with positive dry eye disease (DED) signs on clinical examination or with known DED were excluded. Patients underwent a subjective evaluation for dry eye symptoms using ocular surface disease index (OSDI) and modified standard patient evaluation of eye dryness (SPEED) questionnaires. One day postoperatively, the patients were evaluated again by a questionnaire of pain, discomfort, photophobia, foreign body sensation, satisfaction with vision, and frequency of usage of anesthetic drops. Results. Fifty-two patients had any preoperative dry eye symptoms (OSDI score > 0) compared to 99 nonsymptomatic patients (OSDI score of 0). Postoperatively, the symptomatic dry eye patients suffered significantly more pain than the nondry eye patients (p=0.02). Thirteen patients had a cumulated modified SPEED score >4 (moderate to severe) in comparison to 138 patients with score of 0–4 (non to mild). Patients with moderate to severe preoperative symptoms suffered more pain (p=0.006), photophobia (p=0.005), and epiphora (p=0.03). No statistically significant difference was seen in postoperative subjective visual quality (p=0.82) between the two groups. Conclusion. Preoperative dry eye symptoms may be associated with postoperative pain, epiphora, and photophobia and thus influence negatively on patient satisfaction with this procedure.

TEAR FILM EVALUATION IN CASES OF PARKINSON’S DISEASE

2021 ◽  
pp. 22-24
Author(s):  
V. Meenakshi ◽  
Saswathi Bhushan ◽  
T. Jyothirmayi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dry Eye ◽  
Meibomian Gland ◽  
Blink Rate ◽  
Eye Symptoms ◽  
Tear Meniscus ◽  
Tear Meniscus Height ◽  
Dry Eye Symptoms ◽  
Meibomian Gland Disease

AIM: To evaluate tear lm status in cases of Parkinson's Disease and compare with a study group METHODS:50 patients of Parkinson's Disease and 50 age-gender matched controls were included in this study. Both groups underwent detailed history regarding dry eye symptoms,tear lm evaluation using slit-lamp bio-microscopy, uorescein staining, tear meniscus height, tear breakup time, Schirmer test, blink rate. Statistical analysis was done with Statistical Package for Social Sciences [SPSS] - Version 22.0 Released 2013 version RESULTS: There was a signicant difference between the various groups in terms of distribution of Meibomian Gland Disease 72.0% of the Case group as compared to 40% of control group had Meibomian Gland Disease,There was a signicant difference between the various groups in terms of distribution of Tear Meniscus Height <0.25Mm , Case group had the larger proportion of Tear Meniscus Height of <0.25Mm .There was a signicant difference between the various groups in terms of distribution of Tear Breakup Time <5 Sec, Schirmer's Test <5Mm in 5Min and Blink Rate <10 .There was no signicant difference between the various groups in terms of distribution of corneal Staining and dry eye symptoms. CONCLUSION: The study concluded that patient of Parkinson's disease had higher dry eye symptoms and Meibomian gland disease Also they have reduced Tear miniscus height,Tear lm break up time,Schirmer test I and Blink rate

scholarly journals Improved Dry Eye Symptoms and Signs of Patients With Meibomian Gland Dysfunction by a Dietary Supplement

2021 ◽  
Vol 8 ◽  
Author(s):  
Kangcheng Liu ◽  
Yau Kei Chan ◽  
Xia Peng ◽  
Ruolan Yuan ◽  
Min Liao ◽  
...  
Keyword(s):  
Placebo Group ◽  
Dietary Supplement ◽  
Dry Eye ◽  
Visual Quality ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Supplement Group ◽  
Eye Symptoms ◽  
Symptoms And Signs ◽  
Dry Eye Symptoms

Purpose: To explore the therapeutic effect of a dietary supplement on dry eye with meibomian gland dysfunction (MGD).Methods: Sixty patients with MGD-related dry eye were included in this prospective and randomized, placebo-controlled study. All the subjects were treated with eye hot compress, artificial tears, and antibiotic ointment. After that, the patients received dietary supplementary or placebo daily for 12 weeks. The dry eye signs, function of MG, and visual quality of the patients were assessed at 4, 8, and 12 weeks after the treatment.Results: Twelve weeks after the treatment, patients who received dietary supplement had a significantly better improvement of dry eye symptoms, in terms of ocular surface diseases index and tear breaking-up time (TBUT), than those who received placebo (P &lt; 0.05). The functions of MG, in terms of meibum quality and MG exclusion and MG obstruction scores, were significantly improved in both dietary supplement and placebo groups (P &lt; 0.05). Patients who received dietary supplement had a significantly better improvement in the MG structure, in terms of acinar diameter and acinar density, than those who received placebo (P &lt; 0.05). The number of inflammatory cells near MG was significantly lower in the dietary supplement group when compared with the placebo group (P &lt; 0.05). The objective visual quality was significantly improved in the dietary supplement group, but not in the placebo group (P &lt; 0.05).Conclusion: The dietary supplement can effectively improve the symptoms and signs of MGD-related dry eye, reduce the inflammatory reaction of MG, restore the gland structure, and indirectly improve the visual quality.

scholarly journals The Impact of Conjunctivochalasis on Dry Eye Symptoms and Signs

2015 ◽  
Vol 56 (5) ◽  
pp. 2867 ◽  
Author(s):  
Priyanka Chhadva ◽  
Abigail Alexander ◽  
Allison L. McClellan ◽  
Katherine T. McManus ◽  
Benjamin Seiden ◽  
...  
Keyword(s):  
Dry Eye ◽  
Eye Symptoms ◽  
The Impact ◽  
Symptoms And Signs ◽  
Dry Eye Symptoms

scholarly journals Effect of dry eye diseases on the level of Protein and Lipids in Tears of Postmenopausal Women.

2021 ◽  
Vol 46 (1) ◽  
Author(s):  
A.O. Shuaibu ◽  
G. A. Akinlabi
Keyword(s):  
Postmenopausal Women ◽  
Dry Eye ◽  
Total Protein ◽  
Clinical Signs ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Breakup Time

The study is aimed at investigating the effect of dry eye disease on the level of protein and lipids in tears of postmenopausal women. The study was carried out on 33 postmenopausal women with dry eye symptoms and 22 postmenopausal women that were asymptomatic. The ocular surface disease index (OSDI) questionnaire classified participants as being symptomatic or asymptomatic of dry eye. Tear stability and tear volume were assessed with Fluorescein Tear Break up Time (FBUT) and Schirmer’s test respectively. Tears were analysed for protein (total protein, albumin, and globulin) and lipid (cholesterol and triglycerides). The mean total protein for Dry Eye (DE) was higher than that for Non-dry eye (NDE). Albumin and globulin were also higher for the DE group when compared to the NDE group. These were however, not statistically significant (p > 0.05). There was also no significant difference in triglycerides and cholesterol between DE and NDE. There was no significant correlation between clinical signs (tear volume and tear breakup time) and total protein, albumin, globulin cholesterol and triglycerides in the NDE and DE eye groups. The study shows that proteins and lipids do not change in postmenopausal women irrespective of the presences of dry eye disease.

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