scholarly journals A new antiinflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human aortic wall cells.

1993 ◽  
Vol 91 (3) ◽  
pp. 1225-1230 ◽  
Author(s):  
M Navab ◽  
S Y Hama ◽  
B J Van Lenten ◽  
D C Drinkwater ◽  
H Laks ◽  
...  
Keyword(s):  
Aortic Wall ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Subendothelial Space ◽  
Antiinflammatory Compound

Effect of Simvastatin on the Apoptosis and Permeability of Endothelial Cell Monolayers

2009 ◽  
Author(s):  
Francesco Piraino ◽  
Limary M. Cancel ◽  
Alberto Redaelli ◽  
John M. Tarbell
Keyword(s):  
Endothelial Cell ◽  
Inflammatory Response ◽  
Plasma Proteins ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Chronic Inflammatory Response ◽  
Cell Monolayers ◽  
Subendothelial Space

Atherosclerosis is a chronic inflammatory response in the walls of arteries promoted by plasma proteins that carry cholesterol and triglycerides. The initiating event in atherosclerosis is the transport of low density lipoprotein (LDL) into the subendothelial space.

Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?

2009 ◽  
Vol 47 (2) ◽  
Author(s):  
Eline Verhoye ◽  
Michel R. Langlois
Keyword(s):  
Foam Cell ◽  
Oxidized Ldl ◽  
Subclinical Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Hydroperoxides ◽  
Low Density ◽  
Ldl Particles ◽  
Subendothelial Space ◽  
Aged Subjects

AbstractLow-density lipoproteins (LDLs) are susceptible to structural modifications by oxidation, particularly the small dense LDL particles. The formation of lipid peroxidation derivates, such as thiobarbituric reactive substances, conjugated dienes, lipid hydroperoxides, and aldehydes, is associated with changes in apolipoprotein conformation and affects the functional properties of LDLs. Oxidized LDL (oxLDL) formation in the subendothelial space of the arterial wall is a key initiating step in atherosclerosis because it contributes to foam cell generation, endothelial dysfunction, and inflammatory processes. In the last decade, immunoassays were developed using monoclonal antibodies against oxidation-dependent epitopes of LDL which made it possible to directly measure oxLDL in the circulation. Increased circulating oxLDL concentrations have been related to cardiovascular disease in some studies, although not always independently after adjustment of classical lipid markers. The Asklepios Study, investigating 2524 healthy middle-aged subjects, showed that circulating oxLDL is affected by many biological and lifestyle factors, as well as (generalized) subclinical atherosclerosis.Clin Chem Lab Med 2009;47:128–37.

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

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