scholarly journals Posttranslational modifications define course of prion strain adaptation and disease phenotype

2020 ◽  
Author(s):  
Natallia Makarava ◽  
Jennifer Chen-Yu Chang ◽  
Kara Molesworth ◽  
Ilia V. Baskakov
Keyword(s):  
Posttranslational Modifications ◽  
Disease Phenotype ◽  
Prion Strain ◽  
Strain Adaptation

scholarly journals Prion replication environment defines the fate of prion strain adaptation

2018 ◽  
Vol 14 (6) ◽  
pp. e1007093 ◽  
Author(s):  
Elizaveta Katorcha ◽  
Nuria Gonzalez-Montalban ◽  
Natallia Makarava ◽  
Gabor G. Kovacs ◽  
Ilia V. Baskakov
Keyword(s):  
Prion Strain ◽  
Strain Adaptation

scholarly journals The many shades of prion strain adaptation

Prion ◽  
2014 ◽  
Vol 8 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Ilia V Baskakov
Keyword(s):  
Prion Strain ◽  
Strain Adaptation ◽  
The Many

Neurofilaments and Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 740-743
Author(s):  
J. Metuzals
Keyword(s):  
Animal Model ◽  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Squid Giant Axon ◽  
In Vitro Experiments ◽  
Thin Sections ◽  
Structural Relationships

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.

A Stochastic Model for the Inheritance of the Cancer Proneness Phenotype

1987 ◽  
Vol 26 (03) ◽  
pp. 117-123
Author(s):  
P. Tautu ◽  
G. Wagner
Keyword(s):  
Stochastic Model ◽  
Gaussian Process ◽  
Covariance Function ◽  
Neoplastic Disease ◽  
Disease Phenotype ◽  
Probabilistic Representation ◽  
Temporal Behaviour ◽  
Continuous Trait ◽  
Continuous Parameter ◽  
Level Zero

SummaryA continuous parameter, stationary Gaussian process is introduced as a first approach to the probabilistic representation of the phenotype inheritance process. With some specific assumptions about the components of the covariance function, it may describe the temporal behaviour of the “cancer-proneness phenotype” (CPF) as a quantitative continuous trait. Upcrossing a fixed level (“threshold”) u and reaching level zero are the extremes of the Gaussian process considered; it is assumed that they might be interpreted as the transformation of CPF into a “neoplastic disease phenotype” or as the non-proneness to cancer, respectively.

Posttranslational Modifications of Ribosomal Proteins in Escherichia coli

Acta Naturae ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 22-33 ◽  
Author(s):  
M V Nesterchuk ◽  
P V Sergiev ◽  
O A Dontsova
Keyword(s):  
Escherichia Coli ◽  
Posttranslational Modifications ◽  
Ribosomal Proteins

The effects of long-term vigorous endurance exercise on the coronary arteries

2019 ◽  
Vol 67 (2) ◽  
Keyword(s):  
Endurance Training ◽  
Coronary Atherosclerosis ◽  
Calcium Score ◽  
The Other ◽  
Disease Phenotype ◽  
Male Athletes ◽  
Artery Disease ◽  
Future Work ◽  
Summary Data

Moderate endurance training is known to improve cardiovascular risk factors, and prolongs life expectancy. On the other hand, there has been some discussion whether “too much” exercise might have a contrarious effect by accelerating coronary atherosclerosis. The goal of this review was to evaluate the current literature on the effects of long-term vigorous endurance training on the coronary vasculature. In summary, data point to an increased calcium score, and a higher burden of atherosclerotic plaque in male athletes compared to sedentary controls. However, the plaques found in athletes were more prone to be calcified. The pathogenesis and clinical relevance of this athlete coronary artery disease phenotype remains incompletely understood and represents an area of important future work.

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