Developmental perspectives in child and adolescent depressive symptoms in a community sample

1989 ◽  
Vol 146 (7) ◽  
pp. 871-875 ◽  
2014 ◽  
Vol 26 (1) ◽  
pp. 171-180 ◽  
Author(s):  
Joseph P. Allen ◽  
Joanna Chango ◽  
David Szwedo ◽  
Megan Schad

AbstractThe long-term sequelae of adolescent depressive symptoms were examined in a multimethod, multireporter study of a diverse community sample of 179 adolescents followed from age 14 to 24. Mild to moderate levels of early adolescent depressive symptoms were found to predict lower maternal relationship quality, less positive interactions with romantic partners, and greater loneliness in adulthood even after accounting for prior levels of social functioning and for concurrent levels of adult depressive symptoms. Predictions were partially mediated via late adolescent avoidance of social interactions and poor maternal relationship quality. Results are interpreted as suggesting the potential impact of depressive symptoms on adolescent social development and the need to consider treatment for even mild symptoms and their social concomitants.


2008 ◽  
Author(s):  
D. M. Costello ◽  
J. Swendsen ◽  
J. S. Rose ◽  
L. C. Dierker

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1972
Author(s):  
Ezgi Dogan-Sander ◽  
Roland Mergl ◽  
Anja Willenberg ◽  
Ronny Baber ◽  
Kerstin Wirkner ◽  
...  

Depression and vitamin D deficiency are major public health problems. The existing literature indicates the complex relationship between depression and vitamin D. The purpose of this study was to examine whether this relationship is moderated or mediated by inflammation. A community sample (n = 7162) from the LIFE-Adult-Study was investigated, for whom depressive symptoms were assessed via the German version of CES-D scale and serum 25-hydroxyvitamin D (25(OH)D) levels and inflammatory markers (IL-6 and CRP levels, WBC count) were quantified. Mediation analyses were performed using Hayes’ PROCESS macro and regression analyses were conducted to test moderation effects. There was a significant negative correlation between CES-D and 25(OH)D, and positive associations between inflammatory markers and CES-D scores. Only WBC partially mediated the association between 25(OH)D levels and depressive symptoms both in a simple mediation model (ab: −0.0042) and a model including covariates (ab: −0.0011). None of the inflammatory markers showed a moderation effect on the association between 25(OH)D levels and depressive symptoms. This present work highlighted the complex relationship between vitamin D, depressive symptoms and inflammation. Future studies are needed to examine the effect of vitamin D supplementation on inflammation and depressive symptomatology for causality assessment.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaonan Lin ◽  
Yanmiao Cao ◽  
Linqin Ji ◽  
Wenxin Zhang

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.


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