Clinical Note Granular Cell Tumor of the Pituitary Fossa

Although granular cell tumors are relatively common in the head and neck, symptomatic granular cell tumors of the neurohypophysis are extremely rare. Ophthalmologic symptoms are most common, followed by endocrinologic manifestations. We report a case of a granular cell tumor of the pituitary fossa that was surgically treated. The clinical manifestations, radiographic appearance, and surgical management of granular cell tumors of the pituitary fossa are reviewed, as well as the unique histopathology and electron microscopy of this uncommon neoplasm.

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Coexistent Squamous Cell Carcinoma and Granular Cell Tumor of Head and Neck Region: Report of Two Very Rare Cases and Review of the Literature

International Journal of Surgical Pathology ◽

10.1177/1066896917724513 ◽

2017 ◽

Vol 26 (1) ◽

pp. 47-51 ◽

Cited By ~ 2

Author(s):

Danila Caroppo ◽

Grazia Salerno ◽

Francesco Merolla ◽

Massimo Mesolella ◽

Gennaro Ilardi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Granular Cell Tumor ◽

Neck Region ◽

Granular Cell ◽

Cell Tumor ◽

Head And Neck Region ◽

Pathologic Features

Granular cell tumor (GCT), a relatively rare neuroectodermal tumor occurring most often in the head and neck region, is not uncommonly associated with pseudoepitheliomatous hyperplasia of the overlying surface epithelium, which may be at times nonreadily distinguishable from well-differentiated squamous cell carcinoma (SCC). To the best of our knowledge, only a handful of coexisting SCC and GCT, mostly described in the esophagus, have been reported in (the current) literature so far. We herein report 2 new cases of coexisting GCT and SCC of the head and neck region, located, respectively, in larynx and tongue; comment on their clinical, imaging, and pathologic features; and discuss their management. In the present work, we also review the literature concerning this association to contribute to the head and neck pathologists’ and surgeons’ awareness regarding the possibility of this association for an adequate surgical excision and a better management of these patients.

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A CASE REPORT OF MULTIPLE GRANULAR CELL TUMORS OF TONGUE WITH REVIEW OF LITERATURE.

10.36106/4900839 ◽

2021 ◽

pp. 27-28

Author(s):

Anish Poorna T ◽

Ramya A ◽

Joshna EK ◽

Bobby John

Keyword(s):

Case Report ◽

Head And Neck ◽

Hard Palate ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

The Body ◽

Review Of Literature ◽

Architectural Patterns ◽

Malignant Lesions

Also called as Abrikossoff's tumor, the granular cell tumor (GCT) can occur in any part of the body, most of them occur in the head and neck especially in the tongue, cheek and palate. Almost three fourth of the lesions seen in head and neck are present over the tongue, oral mucosa or hard palate. Both benign and malignant lesions have been reported; although occurrence of malignancy is rare, comprising of 2% of all granular cell tumors. Here we present a case report of granular cell tumor of tongue at two different sites in a 17-year-old girl with a brief review of literature on granular cell tumors. Although oral GCTs exhibit a benign behavior they may demonstrate a wide variety of features and architectural patterns. Rather than a true neoplasm, GCTs could be regarded as lesions that reect a local metabolic or reactive change.

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Granular Cell Tumor of the Breast: Radiologic–Pathologic Correlation

Journal of Breast Imaging ◽

10.1093/jbi/wbab041 ◽

2021 ◽

Author(s):

Suzanne M Ghannam ◽

Gloria J Carter ◽

Tatiana M Villatoro ◽

Wendie A Berg

Keyword(s):

Schwann Cells ◽

Wide Local Excision ◽

Core Biopsy ◽

Breast Imaging ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

The Body ◽

S 100 ◽

Uncommon Neoplasm

Abstract Granular cell tumor (GCT) is an uncommon neoplasm arising from perineural Schwann cells that can arise anywhere in the body and is particularly rare in the breast. Imaging typically shows an irregular, noncalcified mass with high density on mammography and intense posterior shadowing on US that mimics malignancy. Benign GCTs can be locally aggressive and invade the skin or chest wall. Core biopsy is necessary for diagnosis. Polygonal- to spindle-shaped cells with prominent cytoplasmic eosinophilic granules show S-100 and CD68 staining on immunohistochemistry and lack cytokeratin, estrogen, or progesterone expression. The vast majority of GCTs are benign, albeit locally infiltrative, tumors cured by wide local excision.

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Granular Cell Tumor of the Tongue: Report of an Uncommon Neoplasm

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2018.02.309 ◽

2018 ◽

Vol 126 (3) ◽

pp. e95

Author(s):

Robeci Alves Macêdo-Filho ◽

Robéria Lucia De Queiroz Figueiredo ◽

Daliana Queiroga De Castro Gomes ◽

Éricka Janine Dantas Da Silveira ◽

Cassiano Francisco Weege Nonaka ◽

...

Keyword(s):

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Uncommon Neoplasm

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Granular Cell Tumors

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949410300514 ◽

1994 ◽

Vol 103 (5) ◽

pp. 416-419 ◽

Cited By ~ 35

Author(s):

Matthew Kershisnik ◽

John G. Batsakis ◽

Bruce Mackay

Keyword(s):

Soft Tissue ◽

Head And Neck ◽

Granular Cell Tumor ◽

Subcutaneous Tissue ◽

Granular Cell ◽

Cell Tumor ◽

Marginal Excision ◽

Malignant Granular Cell Tumor ◽

Congenital Epulis

The skin and subcutaneous tissue and mucosae of the head and neck are areas of predilection for granular cell tumors. These often histogenetically enigmatic lesions have two principal clinicopathologic presentations: an infantile (congenital) epulis form of the gnathic gingiva and a noncongenital soft tissue and aerodigestive form. Recurrences of either form are largely attributable to marginal excision and, for all sites, approach 15%. A malignant granular cell tumor is recognized, but requires rigorous histologic confirmation.

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Granular Cell Tumor of the Eye (Myoblastoma): Ultrastructural and Immunohistochemical Studies

European Journal of Ophthalmology ◽

10.1177/112067219300300109 ◽

1993 ◽

Vol 3 (1) ◽

pp. 47-52 ◽

Cited By ~ 5

Author(s):

T. Rodríguez-Ares ◽

J. Varela-Durán ◽

M. Sánchez-Salorio ◽

R. Varela-Nuñez ◽

C. Capeans-Tomé ◽

...

Keyword(s):

Electron Microscopy ◽

Light Microscopy ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Distant Disease ◽

Pathological Characteristics ◽

Initial Surgery ◽

S 100 ◽

Immunohistochemical Studies

The clinical and pathological characteristics of a myoblastoma of the orbital are described. The tumor presented as a painless hard mass in the left orbit of a 56-year-old caucasian male, causing diplopia and hypertrophy of the left eye in the primary visual position. Light microscopy studies revealed a typical granular cell tumor with PAS-positive intracytoplasmic granules. Immunoperoxidase studies showed positivity for S-100 protein and desmin. Electron microscopy studies showed numerous intracellular myelin degenerative bodies. The patient developed an epidermoid cyst at the site of initial surgery, but has no signs of local or distant disease two years after initial treatment.

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Granular Cell Tumor of the Larynx in a Six-Year-Old Child: Case Report and Review of the Literature

Ear Nose & Throat Journal ◽

10.1177/014556139807700814 ◽

1998 ◽

Vol 77 (8) ◽

pp. 652-660 ◽

Cited By ~ 16

Author(s):

Ruth S. Holland ◽

Nabil Abaza ◽

Gulnar Balsara ◽

Raymond Lesser

Keyword(s):

Case Report ◽

Head And Neck ◽

Granular Cell Tumor ◽

Adult Population ◽

Granular Cell ◽

Cell Tumor ◽

Additional Case ◽

Review Of The Literature

Granular cell tumors (granular cell myoblastomas) are uncommon neoplasms in the adult population, occurring predominantly in the head and neck and most frequently in the tongue. Laryngeal presentations are unusual, and granular cell tumors of the larynx in children are extremely rare, with a total of 19 cases reported in the literature in children under the age of] 7 years. We report an additional case of a laryngeal granular cell tumor, in a six-year-old boy, and discuss the clinical, histologic, ultrastructural and therapeutic aspects of these neoplasms.

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Granular Cell Tumor of Larynx in a Young Boy

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1018 ◽

2011 ◽

Vol 1 (2) ◽

pp. 74-75 ◽

Cited By ~ 1

Author(s):

PSN Murthy ◽

Vennela Devarakonda ◽

Bhanuprasad LNU ◽

M Anupama ◽

C Sitalatha

Keyword(s):

Head And Neck ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Operating Microscope ◽

Unusual Site ◽

Common Presentation ◽

Vocal Process ◽

Neck Tumors ◽

Biopsy Report

ABSTRACT Granular cell tumors are rare head and neck tumors and not a common presentation in larynx. We present a young boy of 12 years attending with hoarseness of voice. Clinical examination showed a well-defined lesion on the vocal process of the left vocal cord which was excised completely under operating microscope. The biopsy report came as histological surprise as granular cell tumor. The case is presented for its rarity of the lesion in the unusual site of the larynx.

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