Nontraumatic, Nonneoplastic Subglottic Stenosis

1975 ◽  
Vol 84 (6) ◽  
pp. 757-763 ◽  
Author(s):  
Mohsen Djalilian ◽  
Thomas J. McDonald ◽  
Kenneth D. Devine ◽  
Louis H. Weiland
Keyword(s):  
Physical Examination ◽  
Mayo Clinic ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Relapsing Polychondritis ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis ◽  
Initial Presentation ◽  
Systemic Disorder

During a 20-year period, 12 patients with nontraumatic, nonneoplastic subglottic stenosis were seen at the Mayo Clinic. The etiologic factors were relapsing polychondritis, amyloidosis, sarcoidosis, and Wegener's granulomatosis. Because of the diverse initial presentation of the disease, the clinician should consider that the stenosis is a manifestation of a systemic disorder and carry out an otolaryngologic and physical examination with the appropriate roentgenograms and blood and urine tests. Treatment, if a systemic disease is proved, consists of appropriate medication. Surgery may be necessary, depending on the nature of the lesion. Small strictures may not need to be treated.

Endoscopic Management of Severe Subglottic Stenosis in Wegener's Granulomatosis

2000 ◽  
Vol 19 (4) ◽  
pp. 315-317 ◽  
Author(s):  
I. Stappaerts ◽  
C. Van Laer ◽  
K. Deschepper ◽  
P. Van de Heyning ◽  
P. Vermeire
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis ◽  
Endoscopic Management

Wegener’s granulomatosis: diagnostic dilemma

2001 ◽  
Vol 115 (1) ◽  
pp. 46-47 ◽  
Author(s):  
A. Banerjee ◽  
J. M. Armas ◽  
J. H. Dempster
Keyword(s):  
Early Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
The Body ◽  
Facial Nerve Paralysis ◽  
Diagnostic Dilemma ◽  
Nerve Paralysis ◽  
Atypical Presentations ◽  
High Index Of Suspicion

Wegener’s granulomatosis is a systemic disease characterized by a granulomatous lesion that can affect any organ throughout the body.This case-report illustrates the problem posed by a patient presenting with bilateral serous otitis media with marked sensorineural hearing loss, facial nerve paralysis and an atypical serological picture. The importance of early diagnosis and the protocol for the management of a patient with an uncertain diagnosis is discussed. Due to atypical presentations, only a high index of suspicion will ensure an early diagnosis.

Wegener's granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease

2009 ◽  
Vol 123 (12) ◽  
pp. 1375-1377 ◽  
Author(s):  
J E Peters ◽  
A D Salama ◽  
P W Ind
Keyword(s):  
World Literature ◽  
Wegener’S Granulomatosis ◽  
Systemic Vasculitis ◽  
Systemic Disease ◽  
Airway Disease ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Wegener's Granulomatosis ◽  
Airway Stenosis ◽  
History Of ◽  
Tracheobronchial Disease

AbstractObjective:We report a patient with a 20-year history of apparently idiopathic airways stenoses, who presented with an antineutrophil cytoplasmic antibody (ANCA) associated, acute, systemic vasculitis with necrotising glomerulonephritis, subsequently diagnosed as Wegener's granulomatosis.Methods:We present a case report and a review of the world literature on airway stenosis in Wegener's granulomatosis.Results:To our knowledge, this is the first report of Wegener's granulomatosis manifesting as local airway disease for such a prolonged period, before transforming into a systemic vasculitis.Conclusions:This case highlights the need for physicians to be alert to the possibility of Wegener's granulomatosis as a cause of apparently idiopathic airway stenosis, and to be aware that systemic disease may occur in very long-standing, limited Wegener's granulomatosis.

‘Prostate Abscess' as the Initial Manifestation of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)

2014 ◽  
Vol 96 (2) ◽  
pp. 244-246 ◽  
Author(s):  
Sotirios Tsiodras ◽  
Garyfalia Poulakou ◽  
Konstantinos Leventakos ◽  
Helen Panopoulou ◽  
Antonia Elezoglou ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
Initial Manifestation ◽  
Postoperative Fever ◽  
Systemic Involvement ◽  
Left Pleural Effusion ◽  
Antibody Levels

Prostatic involvement in granulomatosis with polyangiitis (GWP), formerly known as Wegener's granulomatosis, is rare, mostly arising in the context of systemic involvement. Prostatic involvement as the first manifestation of this systemic disease is exceptionally rare. We hereby present the case of a 41-year-old male patient who underwent transurethral prostate resection for what was initially diagnosed as suppurative, focally necrotizing prostatitis. Prolonged postoperative fever that did not respond to various treatments, as well as the subsequent appearance of a left pleural effusion, a left upper pulmonary lobe lesion and cutaneous nodules, led to a reevaluation of histological slides which, along with the determination of serum c-ANCA/anti-PR3 antibody levels, established the diagnosis of GWP. Physicians, and especially urologists and infectious diseases specialists, should be aware of this rare association and consider GWP in the event of nonresolving prostatitis, especially when characteristic symptoms from other systems appear.

Wegener's Granulomatosis Presenting as Subglottic Stenosis

2001 ◽  
Vol 7 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Mayra Guerrero ◽  
Eric Gall ◽  
Ermias Tilahun ◽  
Jack Garon
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis

scholarly journals Endoscopic Laser Surgery for Subglottic Stenosis in Wegener's Granulomatosis

2007 ◽  
Vol 48 (5) ◽  
pp. 748 ◽  
Author(s):  
Jacob Shvero ◽  
David Shitrit ◽  
Rumelia Koren ◽  
Dekel Shalomi ◽  
Mordechai Reuven Kramer
Keyword(s):  
Laser Surgery ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis ◽  
Endoscopic Laser ◽  
Endoscopic Laser Surgery

Wegener's granulomatosis, subglottic stenosis and antineutrophil cytoplasm antibodies.

1989 ◽  
Vol 103 (12) ◽  
pp. 1187-1191 ◽  
Author(s):  
T. J. Hoare ◽  
D. Jayne ◽  
P. Rhys Evans ◽  
C. B. Croft ◽  
D. J. Howard
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis ◽  
The Past ◽  
The Future

AbstractWegener's granulomatosis is difficult to diagnose, especially when the presentation is unusual, restricted to an isolated region. We report four cases of recurrent subglottic stenosis posing difficulty in diagnosis. In each case the finding of anti-neutrophil cytoplasm antibodies (ANCA) strongly suggested an underlying vasculitic pathology, Wegener's granulomatosis. We discuss reasons for the difficulty in diagnosis in the past, the possible role of the ANCA assay in such patients, and suggest it should be more widely used in the future.

Aspiration and development of subglottic stenosis in patients with Wegener’s granulomatosis

2009 ◽  
Vol 124 (4) ◽  
pp. 393-396 ◽  
Author(s):  
A C Church ◽  
K Goldsmith ◽  
P Sivasothy
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Bile Salts ◽  
Wegener’S Granulomatosis ◽  
Ph Monitoring ◽  
Wegener's Granulomatosis ◽  
Middle Lobe ◽  
Subglottic Stenosis ◽  
Aetiological Factor ◽  
Significant Difference

AbstractObjective:In patients with Wegener’s granulomatosis, subglottic stenosis can develop due to active disease; however, some patients develop subglottic stenosis with no clear evidence of airway inflammation. In some cases of idiopathic subglottic stenosis, an association with gastroesophageal reflux disease has been found. Our study assessed the potential role of gastroesophageal reflux as an aetiological factor in the development of subglottic stenosis in patients with Wegener’s granulomatosis.Design:We assessed evidence of active reflux disease, using 24-hour pH monitoring and assessment of bile salts in bronchoalveolar lavage fluid.Subjects:Ten Wegener’s granulomatosis patients with subglottic stenosis underwent 24-hour pH monitoring and bronchoscopy and lavage of the right middle lobe. A similar number of control patients were included.Results:There was no statistically significant difference in the occurrence of bronchoalveolar bile salts in patients with subglottic stenosis (n = 2) versus control patients (zero) (p = 0.457). There was good correlation between the detection of reflux by 24-hour pH monitoring and the detection of bronchoalveolar bile salts (κ = 0.769).Conclusion:In this small study of patients with Wegener’s granulomatosis, there was no evidence of an association between the development of subglottic stenosis and gastroesophageal reflux.

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