Practical Assessment of the NBT-PABA Pancreatic Function Test Using High Performance Liquid Chromatography Determination of P-Aminobenzoic Acid in Urine

1985 ◽  
Vol 22 (6) ◽  
pp. 586-590 ◽  
Author(s):  
J. D. Berg ◽  
I. Chesner ◽  
N. Lawson
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Pancreatic Function ◽  
Aminobenzoic Acid ◽  
Pancreatic Function Test ◽  
Function Test

Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid.

1986 ◽  
Vol 32 (6) ◽  
pp. 1010-1012 ◽  
Author(s):  
J D Berg ◽  
I M Chesner ◽  
R A Allen-Narker ◽  
B M Buckley ◽  
N Lawson
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Exocrine Pancreatic Function ◽  
Pancreatic Function ◽  
Aminobenzoic Acid ◽  
Aminosalicylic Acid ◽  
New Approach ◽  
Pharmacokinetic Behavior

Abstract We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.

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