The effect of childhood trauma on age of onset in patients with schizophrenia

2020 ◽  
Vol 66 (8) ◽  
pp. 763-769
Author(s):  
Cem İngeç ◽  
Esin Evren Kılıçaslan
Keyword(s):  
Childhood Trauma ◽  
Clinical Features ◽  
Head Trauma ◽  
Age Of Onset ◽  
Short Form ◽  
Disease Onset ◽  
Psychotic Symptoms ◽  
Childhood Trauma Questionnaire ◽  
Birth Complication ◽  
And Migration

Purpose: Childhood trauma (CT) has been shown to affect the etiology and clinical features of schizophrenia. In this study, it was aimed to investigate the effects of CT on the age of onset (AoO) and clinical features of the disease by considering factors such as family history, head trauma, birth trauma, alcohol and substance abuse that may affect AoO of the disease. Methods: The sample comprising 200 patients admitted to the outpatient and inpatient care at the Izmir Katip Çelebi University, Atatürk Education and Research Hospital psychiatry clinic, were included in the study. Socio-demographic information form, Positive and Negative Syndrome Scale (PANSS), Childhood Trauma Questionnaire-Short Form (CTQ-SF) and subscale of Mini-International Neuropsychiatric Interview (MINI) were applied. Results: All types of trauma, except physical abuse, were found related to the disease onset age earlier. It was also detected that the factors of head trauma, birth complication, presence of an individual diagnosed with schizophrenia in the family and migration history were not related to AoO of the disease. On the other hand, it was found that physical, emotional and sexual abuses lead to more positive psychotic symptoms, and all types of CT increase the severity of disease and the risk of suicide. Conclusion: This study draws attention to the etiological importance of CT in schizophrenia as an environmental factor by showing that it affects AoO of the disease along with symptomatology. Future studies should focus on the pathogenesis of CT in schizophrenia and the interaction between CT and biological and genetic predisposition.

Relationship Between Childhood Trauma and Psychotic Symptoms in Patients with Schizophrenia

2017 ◽  
Vol 41 (S1) ◽  
pp. S269-S269
Author(s):  
E.E. Kılıçaslan ◽  
A. Esen ◽  
M. Izci Kasal ◽  
E. Ozelci ◽  
B. Murat ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Childhood Trauma ◽  
Stepwise Regression ◽  
Negative Symptoms ◽  
Depressive Symptomatology ◽  
Short Form ◽  
Depression Scale ◽  
Psychotic Symptoms ◽  
Positive Symptoms ◽  
Childhood Trauma Questionnaire

IntroductionThe association between childhood trauma and psychotic symptoms is still not clearly understood. Findings for positive and negative symptoms are confounding. This symptomatic response may differ according to the type of childhood trauma, for example childhood abuse was associated with positive symptoms while childhood neglect was associated with negative symptoms.ObjectivesThis study examined the relationship between childhood trauma and psychotic symptoms in schizophrenic patients after controlling for the possible confounding factors, such as clinical features, depression, and sleep quality.MethodsThe childhood trauma questionnaire – short form, Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia, Pittsburgh sleep quality index, and the suicidality subscale of mini-international neuropsychiatric interview were administered to 199 patients with schizophrenia. We used sequential multiple stepwise regression analyses in which positive symptoms, negative symptoms, overall psychopathology and total symptoms of schizophrenia were dependent variables.ResultsDepressive symptomatology and childhood physical abuse (CPA) significantly contributed to positive, negative, general psychopathology and global schizophrenia symptomatology. Stepwise regression analysis results are presented in Table 1.ConclusionsOur findings suggest that CPA during childhood could have an impact on psychopathology in schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Dutch Childhood Trauma Questionnaire—Short Form

2009 ◽  
Author(s):  
Brett D. Thombs ◽  
David P. Bernstein ◽  
Jill Lobbestael ◽  
Arnoud Arntz
Keyword(s):  
Childhood Trauma ◽  
Short Form ◽  
Childhood Trauma Questionnaire

Childhood Trauma Questionnaire--Short Form; Xhosa Version

2010 ◽  
Author(s):  
Rachel K. Jewkes ◽  
Kristin Dunkle ◽  
Mzikazi Nduna ◽  
P. Nwabisa Jama ◽  
Adrian Puren
Keyword(s):  
Childhood Trauma ◽  
Short Form ◽  
Childhood Trauma Questionnaire

scholarly journals Progressive supranuclear palsy in a sample of brazilian population: clinical features of 16 patients

2002 ◽  
Vol 60 (4) ◽  
pp. 917-922 ◽  
Author(s):  
Paulo Eduardo Mestrinelli Carrilho ◽  
Egberto Reis Barbosa
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Clinical Features ◽  
Age Of Onset ◽  
Disease Onset ◽  
Final Diagnosis ◽  
Postural Instability ◽  
Chronic Dacryocystitis ◽  
Neurologic Disorders ◽  
The Mean ◽  
Vertical Gaze

Progressive supranuclear palsy (PSP) is an uncommon disorder characterized by marked postural instability, vertical gaze abnormalities and axial rigidity. The purpose of this study is to report the clinical features of 16 consecutive subjects seen over a 10-year period at a Movement Disorders Clinic. These subjects fulfilled criteria for probable PSP namely those of the National Institute of Neurologic Disorders and Stroke (NINDS) and the Society for PSP (SPSP). This patient-group represented 2.1% of all degenerative parkinsonians observed and the mean age of onset of the disease was 64.7 years (sd = ± 7.2). Postural instability with falls was the most frequent initial feature presented in PSP patients (62.5%). The hallmark of the disease, the supranuclear vertical gaze palsy, appeared after 2.3 years of disease onset, and only 12.5% had such manifestation at the first evaluation. Transient tremor was observed with a relatively high frequency in this group (44%), but only 19% had rest tremor. Chronic dacryocystitis, probably related to a paucity of blinking, was observed in two patients as an inaugural manifestation. In the first evaluation, only 19% of the 16 patients were diagnosed as probable PSP. The mean interval prior to the final diagnosis was 2.4 years.

Nicotine dependence is associated with depression and childhood trauma in smokers with schizophrenia. Results from the Face-SZ dataset

2017 ◽  
Vol 41 (S1) ◽  
pp. s831-s831
Author(s):  
R. Rey ◽  
T. D’amato ◽  
P.M. Llorca ◽  
G. Fond
Keyword(s):  
Smoking Cessation ◽  
Major Depression ◽  
Nicotine Dependence ◽  
Childhood Trauma ◽  
Male Gender ◽  
Community Dwelling ◽  
Psychotic Symptoms ◽  
Childhood Trauma Questionnaire ◽  
Personalized Care ◽  
Questionnaire Score

IntroductionIn a perspective of personalized care for smoking cessation, a better clinical characterization of smokers with schizophrenia (SZ) is needed. The objective of this study was to determine the clinical characteristics of SZ smokers with severe nicotine (NIC) dependence.MethodsTwo hundred and forty stabilized community-dwelling SZ smokers (mean age = 31.9 years, 80.4% male gender) were consecutively included in the network of the FondaMental Expert Centers for schizophrenia and assessed with validated scales. Severe NIC dependence was defined by a Fagerstrom questionnaire score ≥7. Major depression was defined by a Calgary score ≥6. Childhood trauma was self-reported by the Childhood Trauma Questionnaire score (CTQ). Ongoing psychotropic treatment was recorded.ResultsSevere NIC dependence was identified in 83 subjects (34.6%), major depression in 60 (26.3%). 44 (22.3%) subjects were treated by antidepressants. In a multivariate model, severe NIC dependence remained associated with major depression (OR = 3.155, P = 0.006), male gender (OR = 4.479, P = 0.009) and more slightly with childhood trauma (OR = 1.032, P = 0.044), independently of socio-demographic characteristics, psychotic symptoms severity, psychotropic treatments and alcohol disorder.ConclusionNIC dependence was independently and strongly associated with respectively major depression and male gender in schizophrenia, and only slightly with history of childhood trauma. Based on these results, the care of both nicotine dependence and depression should be evaluated for an effective smoking cessation intervention in schizophrenia. Bupropion, an antidepressant that has been found as the potential most effective strategy for tobacco cessation in schizophrenia to date, may be particularly relevant in male SZ smokers with comorbid major depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Validation of the Japanese Version of the Childhood Trauma Questionnaire-Short Form (CTQ-J)

2020 ◽  
Author(s):  
Rie Mizuki ◽  
Takeo Fujiwara
Keyword(s):  
Child Maltreatment ◽  
Childhood Trauma ◽  
Childhood Maltreatment ◽  
Emotional Abuse ◽  
Short Form ◽  
Japanese Version ◽  
Assessment Tools ◽  
Community Group ◽  
Childhood Trauma Questionnaire ◽  
Japanese Adolescents

Abstract Background In Japan, the number of child maltreatment reports has surged to almost ten folds during the last decade. Assessment tools which are concise and easy-to-use are called for, in order to facilitate the process of child maltreatment substantiation as well as to advance research on Japanese people. The Childhood Trauma Questionnaire (CTQ-SF) is accepted internationally as an instrument to assess and quantify experiences of childhood maltreatment and its impact. However, the Japanese version of CTQ-SF has not been validated. The present study examined validity of the Japanese version of the CTQ (CTQ-J). Methods The CTQ-J was administered to Japanese adolescents institutionalized due to child maltreatment and other family issues (institutionalized group, n=31) and adolescents who had no experience of institutionalization (community group, n=46) from the greater Tokyo area. Analysis of Variance was conducted to compare CTQ-J scores among the institutionalized group with documented maltreatment, the institutionalized group without documented maltreatment, and the community group, for the total score and five subscale scores. Then the discrimination of scores assessed by the CTQ-J were calculated using receiver operating characteristic (ROC) curve analysis and compared with documented childhood maltreatment experiences from institutionalized adolescents. Results Internal consistency was ‘good’ to ‘acceptable’ for the CTQ-J in the categories of emotional abuse, physical abuse, sexual abuse, and emotional neglect (Cronbach’s alpha > 0.74). In each maltreatment type, the institutionalized group with documented maltreatment experiences showed significantly higher CTQ-J scores than the community group. The area under the curve (AUC) showed higher discrimination for the total score of the CTQ-J (0.95, 95% confidence interval: 0.90-0.99), and each type of child maltreatment (all AUC: 0.98-0.86). Conclusion This study has demonstrated that the CTQ-J may be used as a reliable tool for childhood maltreatment experience assessment among Japanese adolescents. It is suggested that the CTQ-J has validity by predicting child maltreatment experiences documented in the child welfare records.

scholarly journals Anti-Fibrillarin Antibody in African American Patients with Systemic Sclerosis: Immunogenetics, Clinical Features, and Survival Analysis

2011 ◽  
Vol 38 (8) ◽  
pp. 1622-1630 ◽  
Author(s):  
ROOZBEH SHARIF ◽  
MARVIN J. FRITZLER ◽  
MAUREEN D. MAYES ◽  
EMILIO B. GONZALEZ ◽  
TERRY A. McNEARNEY ◽  
...  
Keyword(s):  
African American ◽  
Systemic Sclerosis ◽  
Clinical Features ◽  
Age Of Onset ◽  
Strong Association ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Cox Proportional Hazards ◽  
Digital Ulcers ◽  
Younger Age

Objective.Anti-U3-RNP, or anti-fibrillarin antibodies (AFA), are detected more frequently among African American (AA) patients with systemic sclerosis (SSc) compared to other ethnic groups and are associated with distinct clinical features. We examined the immunogenetic, clinical, and survival correlates of AFA in a large group of AA patients with SSc.Methods.Overall, 278 AA patients with SSc and 328 unaffected AA controls were enrolled from 3 North American cohorts. Clinical features, autoantibody profile, and HLA class II genotyping were determined. To compare clinical manifestations, relevant clinical features were adjusted for disease duration. Cox proportional hazards regression was used to determine the effect of AFA on survival.Results.Fifty (18.5%) AA patients had AFA. After Bonferroni correction, HLA-DRB1*08:04 was associated with AFA, compared to unaffected AA controls (OR 11.5, p < 0.0001) and AFA-negative SSc patients (OR 5.2, p = 0.0002). AFA-positive AA patients had younger age of disease onset, higher frequency of digital ulcers, diarrhea, pericarditis, higher Medsger perivascular and lower Medsger lung severity indices (p = 0.004, p = 0.014, p = 0.019, p = 0.092, p = 0.006, and p = 0.016, respectively). After adjustment for age at enrollment, AFA-positive patients did not have different survival compared to patients without AFA (p = 0.493).Conclusion.Our findings demonstrate strong association between AFA and HLA-DRB1*08:04 allele in AA patients with SSc. AA SSc patients with AFA had younger age of onset, higher frequency of digital ulcers, pericarditis and severe lower gastrointestinal involvement, but less severe lung involvement compared to AA patients without AFA. Presence of AFA did not change survival.

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