scholarly journals Bacteriæmia and Oral Sepsis

1939 ◽  
Vol 32 (7) ◽  
pp. 747-754 ◽  
Author(s):  
S. D. Elliott

Transient streptococcal bacteriæmias are a frequent sequel to dental extractions especially when the mouth is the seat of severe chronic gum infection. Bacteria may also gain admission to the blood-stream in such cases irrespective of operative procedures and probably as the result, in many instances, of minor degrees of gum injury such as is produced by biting on a loose tooth. Acute apical infections do not appear to be especially associated with blood infection of this kind, the focus of infection here apparently being effectively “walled off” by the associated inflammatory reaction.Of the two factors, infection and trauma, involved in the production of these post-operative bacteriæmias, infection appears to be the more important since, when it is marked, very slight degrees of gum injury are sufficient to produce blood-stream invasion. In the complete absence, however, of the type of trauma induced by the “rocking” of a tooth during its removal, extraction may be accomplished without producing a heavy bacterial shower in the blood.Usually these transient bacteriæmias produce no permanent ill-effect, but there is some evidence that, occurring in subjects with abnormal heart valves, they may lead to subacute infective endocarditis. Thirteen cases are reported where the valvular infection appeared to result from a post-operative dental bacteriæmia.Prevention of such bacteriæmias may be achieved by the reduction or elimination of infection and trauma. Complete elimination of the gum infection is difficult although preliminary treatment of the gum margin by some measure such as cauterization may lessen it and lead to a reduction of the post-operative bacterial shower. Similarly, by manipulating an infected tooth as little as possible during its extraction the incidence or degree of blood infection may be decreased.

2005 ◽  
Vol 26 (3) ◽  
pp. 114
Author(s):  
Derek W S Harty

Infective endocarditis (IE) is a life threatening, endovascular infection occurring when bacteria enter the blood stream and adhere to heart valves. Mortality rates remain in the range of 11-27%. The most common infecting micro-organisms are now the staphylococci (44%) although streptococci (31%) and particularly the oral streptococci (21%) are still major causative agents. Many different oral streptococci have been isolated from IE cases, the most common being Streptococcus sanguinis, Streptococcus oralis, Streptococcus gordonii, Streptococcus mitis, Streptococcus anginosus group and mutans streptococci.


Biomaterials ◽  
1995 ◽  
Vol 16 (17) ◽  
pp. 1283-1289 ◽  
Author(s):  
E.A. Bakkum ◽  
R.A.J. Dalmeijer ◽  
M.J.C. Verdel ◽  
J. Hermans ◽  
C.A. van Blitterswijk ◽  
...  

2019 ◽  
Vol 15 (4) ◽  
pp. 586-592
Author(s):  
E. V. Shikh ◽  
T. E. Morozova ◽  
V. N. Drozdov ◽  
N. B. Lazareva ◽  
D. A. Shatsky ◽  
...  

The frequency of infective endocarditis (IE) has increased 3 times over the past 30 years. The incidence of IE morbidity is recorded in all countries of the world and in the Russian Federation more than 40 people per 1 million population get sick. One of the most frequent causative agents of infective endocarditis is Enterococcus faecalis (E. faecalis), which takes the third place in the structure of the frequency of IE pathogens. Enterococcal IE remains a disease with high mortality, despite the emergence of new groups of antibacterial drugs. This review includes the results of studies of the efficacy and safety of various antimicrobial regimens of IE caused by E. faecalis. The analysis of data from foreign and native studies of antimicrobial treatment in patients with infective endocarditis, accompanied by enterococcal bacteremia is presented in the review. The search for literature performed by using medical databases: MEDLINE, EMBASE, eLIBRARY. The current review included studies of the efficacy and safety of antimicrobial treatment. The main antibiotic therapy regimens of IE caused by E. faecalis include 2 beta-lactam antibiotics or a combination of ampicillin and gentamicin, according to the results of 5 found studies. Found antimicrobial regimens significantly did not affect mortality. Data from international registries testify to the efficacy and safety of daptomycin monotherapy for enterococcal endocarditis. Linezolid and daptomycin are the main drugs of treating infective endocarditis caused by vancomycin-resistant enterococci. Native studies report of a high level of resistance of enterococcal strains to beta-lactam antibacterial drugs. The duration of fever, the frequency of surgical heart valves interventions, the duration of bacteremia are not fully represented in each of the studies, and it is difficult to evaluate these factors. Ampicillin+ceftriaxone and ampicillin+gentamicin are the main antimicrobial treatment regimens of enterococcal endocarditis. Efficacy of these regimens is not significantly different. Treatment of IE should be carried out taking into the epidemiological situation and the strain resistance.


2003 ◽  
Vol 36 (6) ◽  
pp. 697-704 ◽  
Author(s):  
Arthur J. Morris ◽  
Dragana Drinkovic ◽  
Sudha Pottumarthy ◽  
Marianne G. Strickett ◽  
Donald MacCulloch ◽  
...  

Author(s):  
Hadi Mohammadi ◽  
Dylan Goode ◽  
Guy Fradet ◽  
Kibret Mequanint

Transcatheter heart valves are promising for high-risk patients. Generally, their leaflets are made of pericardium stented in a Nitinol basket. Despite their relative success, they are associated with significant complications such as valve migration, implantation risks, stroke, coronary obstruction, myocardial infraction, acute kidney injury (which all are due to the release of detached solid calcific pieces in to the blood stream) and expected issues existing with tissue valves such as leaflet calcification. This study is an attempt to fabricate the first ever polymeric percutaneous valves made of cryogel following the geometry and mechanical properties of porcine aortic valve to address some of the above-mentioned shortcomings. A novel, one-piece, tricuspid percutaneous valve, consisting of leaflets made entirely from the hydrogel, polyvinyl alcohol cryogel reinforced by bacterial cellulose natural nanocomposite, attached to a Nitinol basket was developed and demonstrated. Following the natural geometry of the valve, a novel approach was applied based on the revolution about an axis of a hyperboloid shape. The geometry was modified based on avoiding sharp warpage of leaflets and removal of the central opening orifice area of the valve when valve is fully closed using the finite element analysis. The modified geometry was replaced by a cloud of (control) points and was essentially converted to Bezier surfaces for further adjustment. A cavity mold was then designed and fabricated to form the valve. The fabricated valve was sewn into the Nitinol basket which is covered by Dacron cloth. The models presented in this study merit further development and revisions for both aortic and mitral positions.


2017 ◽  
Vol 120 (10) ◽  
pp. 1884-1890 ◽  
Author(s):  
Laurent Fauchier ◽  
Lauriane Pericart ◽  
Thierry Bourguignon ◽  
Thibaud Genet ◽  
Arnaud Bisson ◽  
...  

2019 ◽  
Vol 81 (6) ◽  
pp. 16
Author(s):  
R. A. Mukhamadiyarov ◽  
N. V. Rutkovskaya ◽  
I. V. Mil'to ◽  
O. D. Sidorova ◽  
L. S. Barbarash

10.12737/5947 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Кузьмина ◽  
Natalya Kuzmina ◽  
Добрынина ◽  
Irina Dobrynina ◽  
Нелидова ◽  
...  

In recent decades there have been significant changes in the clinic of infectious endocarditis. In the presented scientific review detailed analysis of the current characteristics of the clinic and diagnosis is carried out. There is a growing incidence worldwide. Persons of elderly and senile age began to hurt more. According to the latest data, both in Western countries and in Russia to first place in the etiologic structure of infective endocarditis is Staphylococcus aureus. Modern disease is characterized by further increase in the frequency of primary infective endocarditis caused by unmodified heart valves. The septic forms of the disease began to meet less frequently, im-mune pathological manifestations of the disease are observed more often. The classic clinical picture is revealed not always, atypical forms of the disease, the cases of myocardium failure in the patients with infectious endocarditis are detected often. Thromboembolic complications still are among the most frequent and severe complications of infective endocarditis and its have a tremendous impact on his forecast. Recently come to the forefront of cerebral thromboembolic complications. Relapsing course of the disease is more common. The frequency of infective endo-carditis with damage to the valves of the right heart increases. Thus, timely diagnosis of infective endocarditis re-mains a topical problem of modern clinical medicine. The authors conclude that it is necessary to carry out further research in this direction.


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