Herniography (Peritoneography) for Diagnosis of Spigelian Hernia

2005 ◽  
Vol 50 (3) ◽  
pp. 124-125 ◽  
Author(s):  
G Sen ◽  
R Lochan ◽  
B V Joypaul
Keyword(s):  
Clinical Signs ◽  
Rare Condition ◽  
Spigelian Hernia ◽  
Contrast Study ◽  
Ultrasound Scan ◽  
Review Of Literature ◽  
Cross Sectional ◽  
Non Invasive ◽  
Cross Sectional Imaging

Background: Spigelian hernia is a rare clinical condition. It is difficult to diagnose in absence of obvious clinical signs. Ultrasound scan, cross-sectional imaging and contrast studies like herniography have been widely used for detecting occult abdominal wall hernias in symptomatic patients. Aim and methods: We present our experience of detecting a clinically occult Spigelian hernia in a 56-year-old symptomatic male patient, who had concomitant left sided inguinal and Spigelian hernias. In this patient, the Spigelian hernia was not detected on ultrasound scan. We also present a review of literature on the role of herniography in the diagnosis of this rare condition. Results and Conclusion: Herniography is a sensitive investigation for evaluation of occult hernias. However, it is an invasive contrast study and therefore must be used selectively. Non-invasive real-time imaging like ultrasonography remains the first line of investigation for detecting occult hernias.

Proteomics and metabolomics studies exploring the pathophysiology of renal dysfunction in autosomal dominant polycystic kidney disease and other ciliopathies

2019 ◽  
Vol 35 (11) ◽  
pp. 1853-1861 ◽  
Author(s):  
Miriam Zacchia ◽  
Emanuela Marchese ◽  
Elena Martina Trani ◽  
Marianna Caterino ◽  
Giovanna Capolongo ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Clinical Signs ◽  
Research Area ◽  
Clinical Proteomics ◽  
Clinical Feature ◽  
Physiological Importance ◽  
Non Invasive ◽  
Human Disorders ◽  
Autosomal Dominant Polycystic Kidney

Abstract The primary cilium (PC) was considered as a vestigial organelle with no significant physiological importance, until the discovery that PC perturbation disturbs several signalling pathways and results in the dysfunction of a variety of organs. Genetic studies have demonstrated that mutations affecting PC proteins or its anchoring structure, the basal body, underlie a class of human disorders (known as ciliopathies) characterized by a constellation of clinical signs. Further investigations have demonstrated that the PC is involved in a broad range of biological processes, in both developing and mature tissues. Kidney disease is a common clinical feature of cilia disorders, supporting the hypothesis of a crucial role of the PC in kidney homoeostasis. Clinical proteomics and metabolomics are an expanding research area. Interestingly, the application of these methodologies to the analysis of urine, a biological sample that can be collected in a non-invasive fashion and possibly in large amounts, makes these studies feasible also in patients. The present article describes the most recent proteomic and metabolomic studies exploring kidney dysfunction in the setting of ciliopathies, showing the potential of these methodologies in the elucidation of disease pathophysiology and in the discovery of biomarkers.

scholarly journals Role of endoscopy, cross-sectional imaging and biomarkers in Crohn's disease monitoring

Gut ◽  
2013 ◽  
Vol 62 (12) ◽  
pp. 1806-1816 ◽  
Author(s):  
Jose-Manuel Benitez ◽  
Marie-Alice Meuwis ◽  
Catherine Reenaers ◽  
Catherine Van Kemseke ◽  
Paul Meunier ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Monitoring ◽  
Cross Sectional ◽  
Cross Sectional Imaging ◽  
Sectional Imaging

1173Anti-heart and anti-intercalated disk autoantibodies: possible novel biomarkers of cardiac sarcoidosis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Caforio ◽  
S Gianstefani ◽  
A Baritussio ◽  
R Marcolongo ◽  
M Seguso ◽  
...  
Keyword(s):  
Potential Role ◽  
Cardiac Involvement ◽  
Cardiac Sarcoidosis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Non Invasive ◽  
Immune Mediated ◽  
Novel Biomarkers ◽  
Intercalated Disk

Abstract Background Sarcoidosis is an immune-mediated disease; cardiac involvement, a granulomatous form of myocarditis, is under-recognised and prognostically relevant, as it can present with significant morbidity and mortality. Anti-heart autoantibodies (AHA) and anti-intercalated disk autoantibodies (AIDA) are reliable autoimmune markers in non-sarcoidosis myocarditis forms. Purpose The aim of this study was to assess the potential role of serum AHA and AIDA in cardiac sarcoidosis. Methods This is a cross-sectional study on a series of 29 patients with biopsy proven extra-cardiac sarcoidosis and with biopsy-proven or clinically suspected cardiac involvement, who were tested for AHA and AIDA. Patients were recruited in two recruiting tertiary centres, in USA and Italy. AHA and AIDA were detected by indirect immunofluorescence on human myocardium and skeletal muscle. Controls included sera from patients with non-inflammatory cardiac disease (NICD) (n=160), with ischemic heart failure (IHF) (n=141) and normal blood donors (NBD) (n=270). Results The frequencies of AHA and of AIDA were higher in sarcoidosis (86%; 62%) than in NICD (8%; 4%), IHF (7%; 2%), NBD (9%; 0%) (p=0.0001; p=0.0001 respectively). Sensitivity and specificity were: 86% and 92% for positive AHA and 62% and 98% for positive AIDA, respectively (see figure). Figure 1 Conclusions The detection of serum AHA and AIDA in biopsy-proven or clinically suspected cardiac sarcoidosis supports the involvement of heart-specific autoimmunity in the majority of our cases and may provide a novel non invasive diagnostic marker.

The role of tumor markers for relapse detection in central nervous system non-germinomatous germ cell tumors (CNS-NGGCT): A pool analysis of cooperative group clinical trials.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 2503-2503
Author(s):  
Adriana Fonseca ◽  
Cecile Faure-Conter ◽  
Matthew Murray ◽  
Jason R. Fangusaro ◽  
Stewart Goldman ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Pool Analysis ◽  
Cooperative Group ◽  
Cross Sectional ◽  
Highly Sensitive ◽  
North American Data ◽  
Cross Sectional Imaging ◽  
The Uk

2503 Background: CNS-NGGCT are rare tumors that have been successfully treated with multimodal therapies. With a 5-yr EFS and OS of 72-84% and 82-93% respectively, surveillance and relapse detection is essential. Tumor marker (TM) elevation has proven to be a highly sensitive method of relapse detection in extra-cranial-NGGCT. We aim to determine the role of TM for relapse surveillance in children and adolescents with CNS-NGGCTs. Methods: European and North American data from germ cell tumor trials (SIOP GCT96, SFOP-TGM TC 90/92, COG-ACNS0122 and COG-ACNS1123) were pooled for analysis. Additionally, patients treated in the UK, Germany and France under strict protocol-guidelines were included. Details regarding imaging, pathology and TM elevation at diagnosis and relapse were collected. We report the proportion of relapses detectable by TM elevation. Results: Four-hundred and eighty-four patients enrolled in prospective cooperative group CNS-NGGCT trials from 1989 to 2016 were pooled for analysis. One-hundred and thirteen (23%) patients experienced a relapse/progression (SIOP GCT96: n = 57; SFOP TGM TC 90-92 n = 23, COG-ACNS0122 n = 16 & COG-ACNS1123 n = 17) and constitute the population of this report. Median age at diagnosis was 13 (range:1-30) years. The most common primary location was pineal in n = 60 (53%) patients. The site of relapse was available for 100 patients, 48 patients relapsed locally, 36 relapsed with distant disease, combined relapses were seen in 22 patients and 4 patients relapsed with TM elevation alone. TM in serum and/or CSF at diagnosis was available in 93(82%) patients, and in 90(80%) patients at the time of relapse. Eighty-four patients had TM available at both timepoints. At diagnosis 81 (96%) patients had TM elevation and 3 (4%) had negative TM. At relapse, 74(94%) patients with positive TM at diagnosis had TM elevation, while 7(6%) had TM negative. Conversely, 2/3 patients with negative TM at diagnosis, relapsed with elevated TM. Conclusions: Herein, we have assembled the largest prospective cohort to date of relapsed intracranial germ cell tumors. TM are highly sensitive detecting relapse/progression in CNS-NGGCT patients with elevated TM at diagnosis. The routine use of TM for relapse surveillance in patients with CNS-NGGCT can decrease the frequency of cross-sectional imaging, therefore, reducing lengthy hospital visits, sedation procedures and decreasing health-care costs.

Gastroenterology Review and Perspective: The Role of Cross-Sectional Imaging in Evaluating Bowel Damage in Crohn Disease

2011 ◽  
Vol 197 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Benjamin Pariente ◽  
Laurent Peyrin-Biroulet ◽  
Louis Cohen ◽  
Anne-Marie Zagdanski ◽  
Jean-Frédéric Colombel
Keyword(s):  
Crohn Disease ◽  
Cross Sectional ◽  
Cross Sectional Imaging ◽  
Sectional Imaging

Beyond moulage sign and TTG levels: the role of cross-sectional imaging in celiac sprue

2017 ◽  
Vol 42 (2) ◽  
pp. 361-388 ◽  
Author(s):  
Shannon P. Sheedy ◽  
John M. Barlow ◽  
Joel G. Fletcher ◽  
Thomas C. Smyrk ◽  
Francis J. Scholz ◽  
...  
Keyword(s):  
Celiac Sprue ◽  
Cross Sectional ◽  
Cross Sectional Imaging ◽  
Sectional Imaging
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