Outcome of drug resistant tuberculosis in Indian children

We aimed to determine the outcome of bacteriologically confirmed drug-resistant (DR) tuberculosis (TB) in 174 children. We found that DR-TB infected children have nonetheless a high treatment completion rate with a low incidence of fatality and treatment failure. Reversible adverse drug reactions are common during therapy.

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A STUDY ON LIVER FUNCTION TEST PROFILE OF 2ND LINE DRUGS IN MULTI DRUG RESISTANT (MDR) AND EXTENSIVELY DRUG RESISTANT (XDR) TUBERCULOSIS CASES REGISTERED UNDER DR-TB CENTRE IN A TERTIARY CARE HOSPITAL

10.36106/gjra/1900560 ◽

2020 ◽

pp. 1-3

Author(s):

Rupam Kumar Ta ◽

Pronoy Sen

Keyword(s):

Adverse Drug Reactions ◽

Initial Period ◽

Care Hospital ◽

Drug Resistant ◽

Drug Reactions ◽

Drug Resistant Tuberculosis ◽

Intensive Phase ◽

Tb Control ◽

Resistant Tuberculosis ◽

Extensively Drug Resistant

BACKGROUND: The emergence of drug resistant mycobacterium has become a signicant public health problem creating an obstacle to effective Tuberculosis (TB) control. Freedom from TB is possible with timely, regular, complete treatment, with assurance, prevention and management of side effects of antitubercular drugs. Present study was conducted to evaluate common and rare adverse drug reactions (ADR) of CAT IV and CAT V to analyse demographic, radiological and bacteriological prole and treatment outcome in MDR &XDR patients. Aims and Objectives- To evaluate the common and rare adverse drug reactions of intensive phase treatment of Multi Drug Resistant Tuberculosis (MDR) and Extensively Drug Resistant Tuberculosis (XDR) as per WHO-UMC Causality Assessment Scale. METHODS: 76 patients of MDR and XDR Tuberculosis were admitted in DR-TB (Drug Resistant TB) centre, Burdwan Medical College and Hospital and the adverse drug reaction prole of 2nd line drugs were analysed during the intensive phase for a year after fullling the inclusion and exclusion criteria. Treatment was given as per guidelines by Revised National TB Control Program PMDT (Programmatic management of drug-resistant TB). RESULTS:Adverse drug reactions on GI system were nausea 73 patients (96.10%), vomiting 70 (92.10%), acidity 41 (53.9%), and sulphurous belching and hepatitis 1 (1.31%) each. CONCLUSIONS: The reactions were common in rst 60 days of the regimen and in patients with BMI ≤18. Hence vigilant monitoring is required for these types of patients during the initial period and sputum smear and culture conversion is very well correlated with clinical and radiological improvement.

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Adverse Drug Reactions in Patients put on Multi Drug Resistant Tuberculosis (MDR-TB) Treatment in Seven Districts of Central Gujarat

Journal of Young Pharmacists ◽

10.5530/jyp.2015.4s.3 ◽

2015 ◽

Vol 7 (4s) ◽

pp. 425-431 ◽

Cited By ~ 2

Author(s):

Sangita Vashrambhai Patel ◽

Nimavat Kapil Bhikhubhai ◽

Alpesh Bhimabhai patel ◽

Kalpita Samrat Shringarpure ◽

Kedar Gautambhai Mehta ◽

...

Keyword(s):

Adverse Drug Reactions ◽

Drug Resistant ◽

Drug Reactions ◽

Drug Resistant Tuberculosis ◽

Tb Treatment ◽

Resistant Tuberculosis ◽

Multi Drug Resistant Tuberculosis ◽

Mdr Tb

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Impact of adverse drug reactions on the incremental cost-effectiveness of bedaquiline for drug-resistant tuberculosis

The International Journal of Tuberculosis and Lung Disease ◽

10.5588/ijtld.17.0869 ◽

2018 ◽

Vol 22 (8) ◽

pp. 918-925 ◽

Cited By ~ 2

Author(s):

K. Schnippel ◽

C. Firnhaber ◽

L. Page-Shipp ◽

E. Sinanovic

Keyword(s):

Cost Effectiveness ◽

Incremental Cost ◽

Adverse Drug Reactions ◽

Drug Resistant ◽

Drug Reactions ◽

Drug Resistant Tuberculosis ◽

Resistant Tuberculosis

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Adverse events among patients of multi drug resistant tuberculosis receiving second line anti TB treatment

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20150955 ◽

2015 ◽

Vol 1 (6) ◽

pp. 253 ◽

Cited By ~ 1

Author(s):

Kishor B. Rathod ◽

Mangala S. Borkar ◽

Avinash R. Lamb ◽

Sanjay L. Suryavanshi ◽

Gajanan A. Surwade ◽

...

Keyword(s):

Adverse Events ◽

Adverse Drug Reactions ◽

High Protein Diet ◽

Drug Resistant ◽

Second Line ◽

Drug Reactions ◽

Drug Resistant Tuberculosis ◽

Resistant Tuberculosis ◽

Poor Treatment ◽

Mdr Tb

Background: As per WHO’s “Global Tuberculosis Report, 2012”, India accounts for an estimated 64000 patients out of 310000 cases of drug resistant TB estimated to have occurred amongst the notified cases of TB across the globe in a year. MDR-TB is a man-made phenomenon– poor treatment; poor drugs, poor adherence lead to the development of MDR-TB. Treatment of MDR-TB is difficult, much costlier, challenging and needs experience and skills. Reserve drugs are frequently associated with high rates of unacceptable adverse drug reactions, needing change of regimen. Therefore, it is imperative to monitor and treat adverse drug reactions. Methods: The present prospective observational study was carried out at Drug Resistant Tuberculosis Centre at Govt. Medical College, Aurangabad, Maharashtra, to monitor patients for early detection of adverse events after starting treatment till the patients were admitted and later followed up personally or telephonically at regular intervals.Results: We observed adverse drug reactions among 90/265 (33.96 %) patients of whom 90/265 (33.96 %) had gastro intestinal ADRs, followed by ototoxicity 15/265 (5.66%), psychiatric manifestations 14/265 (5.28%), injection site pain swelling 13/265 (4.90%), arthralgia 11/265 (4.15%), dermatological ADRs 7/265 (2.64%), peripheral neuropathy 5/265 (1.88%), renal dysfunction 3/265 (1.13%), change of therapy was only required in 13 psychiatric and 12 ototoxic ADRs.Conclusions: ADRs are more common in MDR TB patients on second line anti tubercular treatment. Good counseling, spacing drugs, high protein diet helps patients to tolerate therapy better and default rate to drop.

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A study of adverse drug reactions in patients receiving treatment for multi-drug resistant tuberculosis

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20170329 ◽

2017 ◽

Vol 6 (2) ◽

pp. 354

Author(s):

Mayur P. Shinde ◽

Nimish R. Halasawadekar ◽

Sunita J. Ramanand ◽

Shraddha M. Pore ◽

Jayprakash B. Ramanand ◽

...

Keyword(s):

Early Detection ◽

Adverse Drug Reactions ◽

Tertiary Care ◽

Care Hospital ◽

Drug Resistant ◽

Drug Reactions ◽

Drug Resistant Tuberculosis ◽

Resistant Tuberculosis ◽

Multi Drug Resistant Tuberculosis ◽

Mdr Tb

Background: A high frequency of adverse drug reactions (ADRs) is one of the major challenges in the treatment of Multi-drug resistant tuberculosis (MDR-TB). Patients may refuse to continue treatment if ADRs are not properly addressed, drugs may be stopped unnecessarily and treatment may be terminated prematurely by inexperienced health workers, resulting in a high proportion of failure.Methods: Patients diagnosed for MDR-TB and registered in Drug Resistant TB centre (DR-TB) of tertiary care hospital during period of July 2014 to June 2015 were enrolled in the study. Data of patients hospitalized for the complaints of ADR in DR-TB centre during study period was collected.Results: Out of 468 patients, 60 (12.82%) patients developed at least one adverse reaction and were hospitalised for the same. Among 109 reported ADRs, Gastrointestinal upset was the most common ADR reported (5.98%) followed by psychosis (4.91%) and ototoxicity (2.99%).Conclusions: The health providers, the patients and their relatives should be sensitised about these ADRs for early detection and treatment. It can also be suggested that the setup of DR-TB centre should be integrated with psychiatry and ENT specialities, with all the provisions of early detection of ADR and treatment.

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