scholarly journals Malignant Tumors of the Nose and Paranasal Sinuses: A Retrospective Review of 291 Cases

2001 ◽  
Vol 80 (4) ◽  
pp. 272-277 ◽  
Author(s):  
David Goldenberg ◽  
Avishai Golz ◽  
Milo Fradis ◽  
Dan Martu ◽  
Aviram Netzer ◽  
...  
Keyword(s):  
Retrospective Study ◽  
General Population ◽  
Paranasal Sinuses ◽  
Retrospective Review ◽  
Malignant Tumors ◽  
Malignant Neoplasms ◽  
Nose And Paranasal Sinuses ◽  
Romanian Population

Malignant neoplasms of the nose and paranasal sinuses are not common among the general population. We present a retrospective study of 291 cases of malignant tumors of the nose and paranasal sinuses that were diagnosed in a northern Romanian population over a period of 35 years. We review the etiology, diagnosis, prognosis, and treatment of these tumors.

scholarly journals Rare Cases in ENT

2018 ◽  
Vol 26 (2) ◽  
pp. 150-154
Author(s):  
Kalyan Pal ◽  
Dipanjan Chakraborty ◽  
Sohag Kundu ◽  
Subrata Mukhopadhyay
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Small Proportion ◽  
Neck Region ◽  
Malignant Neoplasms ◽  
Head And Neck Region ◽  
Nose And Paranasal Sinuses

In our day to day ENT practice we commonly come across diseases involving the larynx, the oral cavity and the paranasal sinuses. These range from inflammatory disorders to benign and malignant neoplasms. Carcinomas involving the head and neck region are most commonly squamous cell carcinoma. However, a small proportion of cases present with other variants of carcinoma or infective pathology uncommon for the site. In this study we present three rare cases encountered in the out-patient department, namely, Primary Malignant Melanoma of the larynx, Neuroendocrine Tumor of the nose and paranasal sinuses and Rhinosporidiosis of cheek.

scholarly journals Retrospective Study of Mammary Lesions in Bitches - Uberlândia, MG, Brazil

2017 ◽  
Vol 45 (1) ◽  
pp. 8
Author(s):  
Mariana Batista Andrade ◽  
Ednaldo Carvalho Guimarães ◽  
Arlinda Flores Coleto ◽  
Nicolle Pereira Soares ◽  
Alessandra Aparecida Medeiros-Ronchi
Keyword(s):  
Retrospective Study ◽  
Tumor Size ◽  
Hormone Receptors ◽  
Malignant Tumors ◽  
Histological Grade ◽  
Mammary Tumors ◽  
Mammary Glands ◽  
Malignant Neoplasms ◽  
The Mean ◽  
Inguinal Glands

Background: Mammary tumors are a type of neoplasia that are most commonly found in female dogs and are mostly malignant. The aim of this study, performed in the Laboratory of Veterinary Pathology of the Federal University of Uberlândia (LVP-FUU) from 2004 to 2014, was to determine the prevalence of mammary tumors in bitches and to verify the relationship between the epidemiological factors (age and breed) and clinicopathological aspects (ulceration, tumor size, and malignancy) in the occurrence of tumors.Materials, Methods & Results: A retrospective study was carried out using histopathological information retrieved from the LPV-UFU database. We collected the information on age and breed of female dogs, as well as about the location, macroscopic aspects, and histological diagnosis of mammary lesions. Only female dogs were considered for this study; a total of 911 histopathological protocols (with only one diagnosis) were analyzed along with 36 protocols that presented more than one diagnosis of mammary tumor. The age of animals ranged from one to 20 years, and the mean age was 9.99 years. The most affected breeds of dogs were: Cross breed (39.56% - 288/728) and Poodle (20.19% - 147/728). The inguinal glands were most affected by the malignant tumors (P < 0.05). A prevalence of tumors bigger than 5 cm in diameter (T3) was observed in the elderly animals (P = 0.0154) and in the inguinal mammary glands (P = 0.044). Simple carcinoma was the most frequent histological type.Discussion: Research shows that more than 40% of the tumors in bitches are located in the mammary glands, emphasizing the importance of this type of neoplasia in female dogs. Mammary tumors develop more frequently in the middle-aged and elderly bitches, with the highest occurrence being in the age range of 8 and 10 years, corroborating our observation in the present study that the mean age of bitches was 9.99 years. In this survey, a higher incidence was observed in mongrel bitches compared to that in the Poodle breed. Some authors affirm that there is no racial predisposition for the occurrence of this pathology; however, a compilation of data suggests a predisposition of at least 10 breeds, with the involvement of an as yet unidentified genetic component. Of these, six breeds (Poodle, Cocker Spaniel, Pointer, Maltese, Yorkshire Terrier, and Dachshund) were found to be predisposed to mammary tumors in this study. The percentage (49.23%) of malignant tumors found in the inguinal glands is consistent with the findings reported in literature, and might be associated with a greater amount of parenchyma, abundance of hormone receptors in these glands, and vascularization provided by the caudal superficial epigastric artery and vulvar branches of external pudendal artery. Tumor size is considered to be a prognostic factor and tumors  ≤ 3 cm in diameter  (T1) have a better prognosis. Consequently, the prevalence of tumors  ≥ 5 cm in diameter  (T3) in elderly animals is probably related to malignancy of the lesions, because tumors usually progress to a worse histological grade with time. The higher occurrence of T3 in inguinal glands might be related to the abundance of parenchyma and/or hormonal receptors in them. As in the present study, data from literature refer to the superiority of malignant histological types, with prevalence varying between 68 and 91%. When prolonged, the time between the onset of tumor and clinical evaluation may be a determinant in the progression from benign to malignant tumors. Among the malignant neoplasms, simple carcinoma was observed to be prevalent, followed by mixed tumors with carcinoma, in agreement with the results of several studies. It is concluded that mammary tumors are more prevalent in older mongrel dogs and Poodle. Attention should be paid to inguinal mammary tumors, because these are mainly malignant.

Malignant neoplasms of the nasal cavities and paranasal sinuses: (A retrospective study)

1977 ◽  
Vol 87 (5) ◽  
pp. 726-736 ◽  
Author(s):  
R. T. Jackson ◽  
G. S. Fitz-Hugh ◽  
William C. Constable
Keyword(s):  
Retrospective Study ◽  
Paranasal Sinuses ◽  
Malignant Neoplasms ◽  
Nasal Cavities

scholarly journals Clinical Study of Malignant Tumors of the Nose and Paranasal Sinuses

1981 ◽  
Vol 74 (5special) ◽  
pp. 959-971
Author(s):  
Fumi Hamaguchi ◽  
Yasuro Miyoshi ◽  
Yasuo Sakakura ◽  
Kotaro Ukai ◽  
Mikikazu Yamagiwa ◽  
...  
Keyword(s):  
Clinical Study ◽  
Paranasal Sinuses ◽  
Malignant Tumors ◽  
Nose And Paranasal Sinuses

scholarly journals Сlinical features of malignant tumors against the background of immunosuppressive therapy in heart transplant recipients

2021 ◽  
Vol 23 (2) ◽  
pp. 167-176
Author(s):  
L. B. Krougly ◽  
N. N. Koloskova ◽  
A. V. Nikulin ◽  
I. V. Pashkov ◽  
V. N. Poptsov ◽  
...  
Keyword(s):  
General Population ◽  
Immunosuppressive Therapy ◽  
Malignant Tumors ◽  
Early Stage ◽  
Immunosuppressive Agents ◽  
Malignant Neoplasms ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Successful Transplantation

As the survival rate of cardiac recipients improves, higher incidence of malignancy in the late postoperative period becomes essential for their prognosis. Immunosuppressive therapy is one of the key prerequisites for successful transplantation. However, long-term use of immunosuppressive agents increases the incidence of malignant tumors compared to the general population. The risk of their development after organ transplantation increases by 2–4 times compared to the general population. For patients who have undergone transplantation since 2000, the risk of developing malignant neoplasms 1–5 years after surgery is estimated at 10–12%. Timely comprehensive examination of patients, development of new immunosuppression schemes, treatment of those predisposing to the development of malignant neoplasms and giving up harmful habits will reduce the risk of malignant tumors and help diagnose these serious complications at an early stage, which, in turn, will increase the life expectancy of solid organ (particularly the heart) recipients.

scholarly journals Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience

2021 ◽  
Vol 11 (3) ◽  
pp. 10-17
Author(s):  
L. G. Castelhano ◽  
F. A. Correia ◽  
D. F. Raposo ◽  
A. H. Campos ◽  
M. R. Melo ◽  
...  
Keyword(s):  
Paranasal Sinuses ◽  
Malignant Tumors ◽  
Disease Free Survival ◽  
Primary Treatment ◽  
Population Based ◽  
Cancer Center ◽  
Nose And Paranasal Sinuses ◽  
Considerable Morbidity ◽  
Clinical Records

Introduction. Although uncommon from a population-based perspective, there is considerable morbidity and mortality associated with malignant tumors of the nose and paranasal sinuses.The objective of this study was to characterize the presentation, risk factors, management and survival of patients with these tumors treated at a single institution.Materials and methods. We retrospectively reviewed the clinical records of patients with malignancies of the nose and paranasal sinuses diagnosed between January 2010 and December 2014 at a tertiary cancer center. Univariate and multivariate analysis were performed.Results. Ninety patients were included in the study. Mean age at diagnosis was 62.8 years (range, 2–95 years) and mean follow-up was 44.5 months (range, 2–113 months). The maxillary sinus (33.3 %) and the nasal cavity (32.2 %) were the most frequent sites of origin. Squamous cell carcinoma (36.7 %), mucosal melanoma (15.6 %) and adenoid cystic carcinoma (10 %) were the most common histologic subtypes. Surgery was the primary treatment for 86.7 % of patients. Recurrence occurred in 45 patients (50 %). The overall 5‑year survival was 39.3 % and disease free-survival was 45.9 %. Survival was significantly decreased in non-smokers (p = 0.022), T3–4 tumors (p = 0.007), positive lymph nodes (p <0.001), nonepithelial tumors (p = 0.036) and positive margins (p = 0.032). Survival was not affected by surgical approach between endoscopic, open and combined approaches (p = 0.088).Conclusion. Prognosis is poor, with high recurrences and low survival, but clearly histology, location and stage-dependent. Sound oncologic principles, with complete resections and negative margins, result in a better outcome.

scholarly journals Anterior Craniofacial (Transcranial) Resection for Tumors of Nose and Paranasal Sinuses: Surgical Technique

2011 ◽  
Vol 3 (3) ◽  
pp. 197-201
Author(s):  
Saurabh Varshney ◽  
SS Bist ◽  
Sarita Mishra ◽  
Charitesh Gupta ◽  
Sanjiv Bhagat ◽  
...  
Keyword(s):  
Paranasal Sinus ◽  
Paranasal Sinuses ◽  
Malignant Tumors ◽  
Cribriform Plate ◽  
Anterior Cranial Fossa ◽  
Craniofacial Resection ◽  
Csf Leakage ◽  
Cranial Fossa ◽  
The Mean ◽  
Nose And Paranasal Sinuses

ABSTRACT Background Management of nose and paranasal sinus tumors involving the cribriform plate with or without invasion of anterior cranial fossa is complex due to the anatomic detail of the region and the variety of tumors that occur in this area. Anterior craniofacial resection is recognized as the best treatment for nose and paranasal sinus, tumors involving the cribriform plate with or without invasion of anterior cranial fossa. Craniofacial resection allows wide exposure of the complex anatomical structures at the base of skull permitting monobloc tumor resection. Methods Twenty-one patients underwent anterior craniofacial resection for nose and paranasal sinus tumors involving the cribriform plate with or without invasion of anterior cranial fossa at Himalayan Institute of Medical Sciences, Dehradun between 2000 and 2011 by a team of head-neck surgeons and neurosurgeons. Results The series included 16 malignant tumors of the nose and paranasal sinuses and five extensive benign lesions. The mean age was 47.4 years (range, 12 to 68 years). There were 16 men and five women (M:F- 3.2:1.0). Four patients had a recurrence after previous treatments (surgery and/or radiotherapy). The histological subdivision was as follows: Seven cases of squamous cell carcinoma, four cases of adenocarcinoma, three cases of esthesioneuroblastoma, and two cases of undifferentiated tumors. All tumors were resected by a combined bifrontal craniotomy and rhinotomy. The skull base was closed with a pediculated pericranial flap and a split-thickness free skin graft underneath. There were no postoperative problems of CSF-leakage or meningitis, two patients had wound infection. Recurrent tumor growth or systemic metastasis occurred in three (18.75%) out of 16 patients with malignant tumors, 6 months to 2 years postoperatively. The mean follow-up was 16 months. Conclusion An anterior craniofacial resection should be performed in cases of nose and paranasal sinus tumors involving the cribriform plate with or without invasion of anterior cranial fossa.

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