scholarly journals Retrospective Study of Mammary Lesions in Bitches - Uberlândia, MG, Brazil

2017 ◽  
Vol 45 (1) ◽  
pp. 8
Author(s):  
Mariana Batista Andrade ◽  
Ednaldo Carvalho Guimarães ◽  
Arlinda Flores Coleto ◽  
Nicolle Pereira Soares ◽  
Alessandra Aparecida Medeiros-Ronchi
Keyword(s):  
Retrospective Study ◽  
Tumor Size ◽  
Hormone Receptors ◽  
Malignant Tumors ◽  
Histological Grade ◽  
Mammary Tumors ◽  
Mammary Glands ◽  
Malignant Neoplasms ◽  
The Mean ◽  
Inguinal Glands

Background: Mammary tumors are a type of neoplasia that are most commonly found in female dogs and are mostly malignant. The aim of this study, performed in the Laboratory of Veterinary Pathology of the Federal University of Uberlândia (LVP-FUU) from 2004 to 2014, was to determine the prevalence of mammary tumors in bitches and to verify the relationship between the epidemiological factors (age and breed) and clinicopathological aspects (ulceration, tumor size, and malignancy) in the occurrence of tumors.Materials, Methods & Results: A retrospective study was carried out using histopathological information retrieved from the LPV-UFU database. We collected the information on age and breed of female dogs, as well as about the location, macroscopic aspects, and histological diagnosis of mammary lesions. Only female dogs were considered for this study; a total of 911 histopathological protocols (with only one diagnosis) were analyzed along with 36 protocols that presented more than one diagnosis of mammary tumor. The age of animals ranged from one to 20 years, and the mean age was 9.99 years. The most affected breeds of dogs were: Cross breed (39.56% - 288/728) and Poodle (20.19% - 147/728). The inguinal glands were most affected by the malignant tumors (P < 0.05). A prevalence of tumors bigger than 5 cm in diameter (T3) was observed in the elderly animals (P = 0.0154) and in the inguinal mammary glands (P = 0.044). Simple carcinoma was the most frequent histological type.Discussion: Research shows that more than 40% of the tumors in bitches are located in the mammary glands, emphasizing the importance of this type of neoplasia in female dogs. Mammary tumors develop more frequently in the middle-aged and elderly bitches, with the highest occurrence being in the age range of 8 and 10 years, corroborating our observation in the present study that the mean age of bitches was 9.99 years. In this survey, a higher incidence was observed in mongrel bitches compared to that in the Poodle breed. Some authors affirm that there is no racial predisposition for the occurrence of this pathology; however, a compilation of data suggests a predisposition of at least 10 breeds, with the involvement of an as yet unidentified genetic component. Of these, six breeds (Poodle, Cocker Spaniel, Pointer, Maltese, Yorkshire Terrier, and Dachshund) were found to be predisposed to mammary tumors in this study. The percentage (49.23%) of malignant tumors found in the inguinal glands is consistent with the findings reported in literature, and might be associated with a greater amount of parenchyma, abundance of hormone receptors in these glands, and vascularization provided by the caudal superficial epigastric artery and vulvar branches of external pudendal artery. Tumor size is considered to be a prognostic factor and tumors  ≤ 3 cm in diameter  (T1) have a better prognosis. Consequently, the prevalence of tumors  ≥ 5 cm in diameter  (T3) in elderly animals is probably related to malignancy of the lesions, because tumors usually progress to a worse histological grade with time. The higher occurrence of T3 in inguinal glands might be related to the abundance of parenchyma and/or hormonal receptors in them. As in the present study, data from literature refer to the superiority of malignant histological types, with prevalence varying between 68 and 91%. When prolonged, the time between the onset of tumor and clinical evaluation may be a determinant in the progression from benign to malignant tumors. Among the malignant neoplasms, simple carcinoma was observed to be prevalent, followed by mixed tumors with carcinoma, in agreement with the results of several studies. It is concluded that mammary tumors are more prevalent in older mongrel dogs and Poodle. Attention should be paid to inguinal mammary tumors, because these are mainly malignant.

scholarly journals Canine Mammary Tumors

1970 ◽  
Vol 7 (4) ◽  
pp. 289-320 ◽  
Author(s):  
J. E. Moulton ◽  
D. O. N. Taylor ◽  
C. R. Dorn ◽  
A. C. Andersen
Keyword(s):  
Alveolar Epithelium ◽  
Mammary Tumors ◽  
Malignant Neoplasms ◽  
Intact Female ◽  
Female Population ◽  
Fibrous Stroma ◽  
Different Populations ◽  
The Mean ◽  
Mixed Tumors ◽  
Solid Type

A retrospective study was conducted of 1,366 cases of canine mammary neoplasms derived from 3 different populations of dogs. The mean ages for occurrence of mammary tumors varied between populations studied from the ninth to eleventh years with malignant neoplasms tending to occur later than benign. Irradiation had no effect on incidence. Poodles had the largest numbers of papillary adenomas and benign mixed tumors. Dachshunds, chihuahuas, and cocker spaniels had a large proportion of all other types. Papillary adenomas arose from the ductile or alveolar epithelium and accounted for only 5.1% of the tumors. Benign mixed rumors comprised 45.1% and consisted of an adenomatous epithelial component and proliferative fibrous connective tissue or myoepithelium which frequently had undergone metaplasia to cartilage or bone. Malignant mixed tumors accounted for 8.5%, their malignant component being most frequently epithelial. Carcinomas represented 39.7% of the tumors. More carcinomas were seen among neutered than intact females except in the closed beagle colony where carcinoma was the most frequent neoplasm in the exclusively intact female population. Among the carcinomas, an infiltrating type, usually comprised of ductile cells infiltrating an abundant fibrous stroma, was the most common. A solid type, comprised of masses of epithelial cells with scant or inapparent stroma, was next in frequency. Papillary, lobular, and squamous types of carcinomas occurred in descending order. Malignant myoepitheliomas comprised 1.1% of the tumors; fibrosarcomas, osteosarcomas, and chondrosarcomas were rare, accounting for less than 1%. Approximately 2% of the neoplasms were from males which had no predilection for a particular type of rumor.

scholarly journals The Significance Of Hormone Receptors In Male Breast Cancer

2020 ◽  
Author(s):  
Yevhen Hotko
Keyword(s):  
Breast Cancer ◽  
Survival Rate ◽  
Hormone Therapy ◽  
Hormone Receptors ◽  
Malignant Tumors ◽  
Locally Advanced ◽  
Male Breast ◽  
Steroid Hormone Receptors ◽  
Malignant Neoplasms ◽  
Breast Cancer Patients

Abstract Background Male mammary glands are usually considered a rudimentary organ. However, they may be exposed to similar pathological influences as female breasts. These pathological influences may cause the development of malignant breast tumors. Breast cancer in males is a rare disease, nevertheless, it is a serious problem. According to numerous national cancer registries from around the world, this disease takes 1% on average in the structure of morbidity of malignant neoplasms of this organ in both sexes. Methods In our study (168 patients) estrogen receptors were positive in the tumors of 75% of patients. The positive rate of progesterone receptors was observed in 44% of patients. The detection rate of steroid hormone receptors in malignant tumors of the male breast ranges from 65 to 100%, depending on the criteria for identifying their positivity level. The hormone therapy in the early and late stages of cancer include antiestrogens, steroid and non-steroid aromatase inhibitors, both as monotherapy and in combination with LHRH-agonists, fulvestrant and other hormonal agents. Results There was no dependence found between the receptor status of the tumors and the age of patients with breast cancer. Breast cancer in men has a more aggressive course than the same disease in women. This means lower survival rate of male patients, greater number of locally advanced and metastatic cases, with delayed primary treatment, and resistance to treatment compared to female breast cancer patients. The incidence of receptor positive tumors in men does not increase with age, as observed in women with breast cancer. Despite numerous reports on the effectiveness of hormone therapy in men with breast cancer, many aspects of this type of therapy remain largely unexplained. Conclusions Hormone therapy appears the most effective in patients with the so-called feminization syndrome, which includes signs of hyperestrogenemia, as well as in patients with multiple unfavorable prognostic signs (stage III of cancer, low differentiation of tumor cells, status of regional lymph nodes N2-3, medium, severe and morbid obesity). Orchiectomy does not increase the survival rate, therefore, its application is impractical.

scholarly journals Malignant Tumors of the Nose and Paranasal Sinuses: A Retrospective Review of 291 Cases

2001 ◽  
Vol 80 (4) ◽  
pp. 272-277 ◽  
Author(s):  
David Goldenberg ◽  
Avishai Golz ◽  
Milo Fradis ◽  
Dan Martu ◽  
Aviram Netzer ◽  
...  
Keyword(s):  
Retrospective Study ◽  
General Population ◽  
Paranasal Sinuses ◽  
Retrospective Review ◽  
Malignant Tumors ◽  
Malignant Neoplasms ◽  
Nose And Paranasal Sinuses ◽  
Romanian Population

Malignant neoplasms of the nose and paranasal sinuses are not common among the general population. We present a retrospective study of 291 cases of malignant tumors of the nose and paranasal sinuses that were diagnosed in a northern Romanian population over a period of 35 years. We review the etiology, diagnosis, prognosis, and treatment of these tumors.

scholarly journals Kis méretű vesedaganatok patológiai és biológiai jellemzőinek elemzése a tumorméret alapján

2021 ◽  
Vol 162 (42) ◽  
pp. 1693-1697
Author(s):  
Csaba Berczi ◽  
Zsolt Bacsó ◽  
László Bidiga ◽  
Judit Nagy ◽  
Tibor Flaskó
Keyword(s):  
Tumor Size ◽  
Malignant Tumors ◽  
Benign Lesion ◽  
Renal Tumors ◽  
Biological Behavior ◽  
Invasive Treatment ◽  
Renal Masses ◽  
Significant Difference ◽  
The Mean ◽  
Grade 3

Összefoglaló. Bevezetés: A kis méretű vesedaganatok között lényegesen gyakoribbak a benignus elváltozások, és a kis malignus tumorok biológiai tulajdonságai is kedvezőbbek, mint a nagyobb daganatokéi. Célkitűzés: Szerzők a kis méretű vesetumorok tulajdonságait vizsgáltuk különböző alcsoportokban. Módszer: 2000. január 1. és 2015. január 1. között 1272 beteg esetén végeztünk műtétet vesedaganat miatt. Közülük 496 betegnek volt kis méretű vesetumora. A betegek átlagéletkora 59 ± 12 év volt. A betegeket a tumorméret alapján három csoportba osztottuk. Az 1. csoportban a daganat mérete ≤4 cm, a 2. csoportban ≤3 cm és a 3. csoportban ≤2 cm volt. Eredmények: Az eltávolított daganat nagysága átlagosan 29 ± 8 mm volt. A szövettan 418 esetben (84%) malignus, míg 78 alkalommal (16%) benignus elváltozást mutatott. A 2 cm-nél kisebb daganatoknál malignitás csak az esetek 73,2%-ában fordult elő. A malignus és a benignus tumorok méretében szignifikáns eltérés volt (p = 0,008). Rosszul differenciált daganat – grade 3. és 4. – az esetek 10,8%-ában, 14,4%-ában, illetve 20,7%-ában volt jelen, amikor a tumorméret kisebb mint 2 cm, 2,1–3 cm, illetve 3,1–4,0 cm volt. A vesecarcinomáknál az átlagosan 10 éves utánkövetési idő alatt progresszió az esetek 5,5%-ában fordult elő. Következtetés: A kis méretű vesetumor az összes vesedaganat 39%-át tette ki. Ezek nagy része malignus volt, és benignus elváltozás az esetek 16%-ában fordult elő. A malignitás előfordulása a 2 cm-nél kisebb tumoroknál volt a legalacsonyabb. A tumorméret szoros összefüggést mutatott a malignitás gyakoriságával és a daganat differenciáltságával. A kedvező patológiai és biológiai eredmények alapján a 2 cm alatti daganatoknál felmerül annak lehetősége, hogy esetükben az aktív követés vagy minimálisan invazív kezelés alkalmazása kerüljön előtérbe. Orv Hetil. 2021; 162(42): 1693–1697. Summary. Introduction: The incidence of benign lesions is more common in small renal masses (SRMs) and biological behavior of small malignancies is better compared to larger ones. Objective: The authors measured the characteristics of SRMs in different subgroups. Method: From January 1, 2000 to January 1, 2015, 1272 patients underwent surgery for renal tumors. In 496 of the 1272 cases, the patients had SRMs. The mean age of the patients was 59 ± 12 years. Based on the sizes, the SRMs were divided into three groups. The sizes of the renal tumors were ≤4 cm in Group 1, ≤3 cm in Group 2 and ≤2 cm in Group 3. Results: The mean diameter of the removed SRMs was 29 ± 8 mm. Histology confirmed renal cell carcinoma in 418 cases (84%), while benign tumor was present in 78 patients (16%). However, with the tumor size ≤2 cm, malignancy was detected in 73.2% of the cases. There was a significant difference in the sizes of the malignant and the benign masses (p = 0.008). Grade 3 or 4 tumors were present in 10.8%, 14.4% and 20.7% when the tumor size was ≤2 cm, 2.1 to 3 cm, and 3.1 to 4 cm in diameter, respectively. During the mean 10-year follow-up period, tumor progression was detected only in 5.5% of malignancies. Conclusion: In 39% of all cases, the patients had SRMs. The majority of SRMs were malignant, and benign lesion occurred only in 16% of the cases. The incidence of malignant tumors was the lowest when the size of SRMs was ≤2 cm. The size of the tumor was highly associated with probability of malignancy and tumor grading. Based on the favorable pathological and biological results in tumors below 2 cm, active surveillance or minimally invasive treatment could be the preferred management. Orv Hetil. 2021; 162(42): 1693–1697.

STUDY ON RELATION BETWEEN TRADITIONAL PROGNOSIS FACTORS AND HORMONE RECEPTORS STATUS, KI-67, HER2 IN INVASIVE BREAST CARCINOMA

2017 ◽  
pp. 70-76
Author(s):  
Cong Thuan Dang ◽  
Thi Thu Thuy Phan ◽  
Nam Dong Tran ◽  
Cao Sach Ngo ◽  
Thi Hong Van Vo
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Hormone Receptors ◽  
Histological Grade ◽  
Invasive Breast Carcinoma ◽  
Disease Stage ◽  
Ki 67 ◽  
Node Metastasis

Objectives: To examine histopathologic features and hormone receptors status, Ki-67 and HER2 in invasive breast carcinoma at Hue University Hospital to evaluating the relation between tumor size, histological grade, lymph node metastasis status, disease stage and the expression of steroid hormone receptors status, Ki-67 and HER2 in invasive breast carcinoma. Materials and methods: From May 2015 to April 2016, samples were collected from 96 breast carcinoma patients. Histopathologic samples were stained by Hematoxylin-Eosin and immunohistochemistry staining at Pathology Department, Hue University Hospital. R esults: Most invasive breast carcinoma patients were among the age of 50-59 (39.6%), invasive ductal carcinoma (82.3%), tumor size ≤2cm (54.2%), histological grade II (60.2%), lymph node metastasis (53.1%), disease stage II (51%); ER(+) 46.9%, PR(+) 49.0%, Ki-67(+) 77.1%, HER2(+) 30.2% of cases. Conclusion: There were a positive correlation between histological grade with the HER2 expression (p<0.05) in invasive breast carcinoma. Key words: invasive breast carcinoma, immunohistochemistry, tumor size, histological grade, lymph node metastasis, disease stage

Expression of Connexins 26 and 43 in Canine Hyperplastic and Neoplastic Mammary Glands

2005 ◽  
Vol 42 (5) ◽  
pp. 633-641 ◽  
Author(s):  
L. N. Torres ◽  
J. M. Matera ◽  
C. H. Vasconcellos ◽  
J. L. Avanzo ◽  
F. J. Hernandez-Blazquez ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gap Junctions ◽  
Cell Membranes ◽  
Malignant Tumors ◽  
Mammary Glands ◽  
Nuclear Antigen ◽  
Malignant Neoplasms ◽  
Mammary Neoplasms ◽  
Punctate Pattern ◽  
E Cadherin

Gap junctions are the only communicating junctions found in animal tissues and are composed of proteins known as connexins. Alterations in connexin expression have been associated with oncogenesis; reported studies in rodent and human mammary glands, which normally express connexins 26 and 43, confirm these alterations in malignancies. Mammary neoplasms represent the second most frequent neoplasm in dogs, and since there are no reports on the study of connexins in canine mammary glands, the present study investigated the expression of connexins 26 and 43 in normal, hyperplastic, and neoplastic mammary glands of this species, to verify if altered patterns of connexin staining are related to higher cell proliferation and malignant phenotypes. A total of 4 normal, 8 hyperplastic mammary glands, 9 benign, and 51 malignant mammary gland neoplasms were submitted for the immunostaining of connexins 26 and 43, E-cadherin, and proliferating cell nuclear antigen (PCNA). Normal, hyperplastic, and benign neoplastic mammary glands showed a punctate pattern for connexin 26 and 43 staining and an intercellular E-cadherin staining. Malignant neoplasms, especially the most aggressive cases with high cell proliferation rates, presented either fewer gap junction spots on the cell membranes or increased cytoplasmic immunostaining. Malignant tumors also expressed a less intense immunostaining of E-cadherin; the expression of this adhesion molecule is important for the transportation of connexins to cell membranes and in forming communicating gap junctions. Deficient expression of E-cadherin could be related to the aberrant connexin localization and may contribute to the malignant phenotype. In conclusion, the expression and distribution of connexins and E-cadherin are inversely correlated to cell proliferation in malignant mammary neoplasms of dogs and may well be related to their more aggressive histologic type and biologic behavior.

scholarly journals Cytokines and Prognostic Factors in Epithelial Ovarian Cancer

2016 ◽  
Vol 10 ◽  
pp. CMO.S38333 ◽  
Author(s):  
Millena Prata Jammal ◽  
Agrimaldo Martins-Filho ◽  
Thales Parenti Silveira ◽  
Eddie Fernando Candido Murta ◽  
Rosekeila Simões Nomelini
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factors ◽  
Malignant Tumors ◽  
Histological Grade ◽  
Tumor Development ◽  
Delayed Diagnosis ◽  
Disease Free Survival ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Benign Neoplasms

Introduction Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. Method The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. Results TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 ( P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 ( P = 0.03) more frequently. Conclusion IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies.

scholarly journals Tumors with Pilosebaceous Differentiation: A Five Year Retrospective Study at BPKIHS

2018 ◽  
Vol 11 (1) ◽  
pp. 33-39
Author(s):  
P Paudyal ◽  
A Pradhan ◽  
S Pokharel ◽  
N Sah ◽  
S Karki ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Who Classification ◽  
Malignant Tumors ◽  
Routine Practice ◽  
Diverse Group ◽  
Microsoft Excel ◽  
Common Location ◽  
The Mean ◽  
Follicular Tumors ◽  
Age And Sex

Background: Skin appendageal tumors (SAT) are a large and diverse group of tumors that are commonly classified according to their state of appendageal differentiation: Follicular, sebaceous, eccrine and apocrine. Most adnexal neoplasms are uncommonly encountered in routine practice, and pathologists can easily recognise frequently encountered tumours. In this study, the histological features of important benign and malignant tumors of pilosebaceous origin were reviewed considering its morphologic types, subtypes, age, sex and anatomic site.Methods: This is a hospital based retrospective study which includes all cases of tumors with pilosebaceous differentiation diagnosed histologically during the period of five years (1st January, 2008 to 31st December, 2012). Tumors were analyzed considering the anatomic location and type of the tumor, along with age and sex of the patient. The Histological characterization was done according to the WHO classification system for SAT. Collected data were entered in Microsoft Excel 2000 and converted it into SPSS PC+ 11.5 Version for statistical analysis.Results: A total of 53 neoplasms of pilosebaceous differentiation included, 52 (98.1%) were benign and one (1.8%) was malignant. The mean age was 39.23 years. Females comprised of 35 (66%) and 18 (34%) were males. Most common location was in head and neck area. Of all, 51 (96.2%) tumors were follicular, and two (3.7%) were with sebaceous differentiation. Among all follicular tumors, Pilomatricoma (33.9%), Keratoacanthoma (26.4%) and Trichoepithelioma (22.6%) were the commonest tumors observed.Conclusion: The study findings reveal majority of the tumors origin were of follicular differentiation and all were benign. J-GMC-N | Volume 11 | Issue 01 | January-June 2018, Page: 33-39

scholarly journals Annexin A3 as a Prognostic Biomarker for Breast Cancer: A Retrospective Study

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Tao Zhou ◽  
Yong Li ◽  
Li Yang ◽  
Tiantian Tang ◽  
Lina Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Tumor Size ◽  
Histological Grade ◽  
Clinical Stage ◽  
Menopausal Status ◽  
Disease Free Survival ◽  
Breast Cancer Patients ◽  
Lymphatic Metastases ◽  
Tumor Node Metastasis Stage

To validate the correlation between ANXA3 expression and prognosis in breast cancer, a retrospective study encompassing 309 breast cancer patients was performed. The expression of ANXA3 was determined by the immunohistochemical examination of tissue sections by the Max Vision™ method. The ANXA3 levels in the patient samples were validated for the prognosis based on age, menopause status, tumor size, tumor node, metastasis stage, the number of lymphatic metastases, oncology grade, and molecular subtyping. An elevated expression of ANXA3 was detected in breast cancer samples, compared to adjacent tissue samples, and significant correlation depending on the number of lymphatic metastases (P=0.001) and histological grade (P=0.004) was observed. The number of lymphatic metastases and ANXA3 expression were identified as independent risk factors affecting the disease-free survival and overall survival. Significantly (P<0.002) higher level of ANXA3 was detected in triple-negative breast cancer compared to other subtypes. There was no significant (P>0.05) change in the expression of ANXA3 with respect to age, menopausal status, tumor size, and clinical stage. The findings implicate the expression of ANXA3 with the natural progression of breast cancer and associate it with increased lymphatic metastasis. The study validates the use of ANXA3 as a potential prognosis biomarker for breast cancer.

scholarly journals Prognostic factors and overall survival of breast cancer in the city of Goiania, Brazil: a population-based study

2017 ◽  
Vol 44 (5) ◽  
pp. 435-443 ◽  
Author(s):  
Ruffo de Freitas Júnior ◽  
Rodrigo Disconzi Nunes ◽  
Edesio Martins ◽  
Maria Paula Curado ◽  
Nilceana Maya Aires Freitas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Tumor Size ◽  
Hormone Receptors ◽  
Population Based ◽  
Axillary Lymph Nodes ◽  
Malignant Neoplasms ◽  
Axillary Lymph ◽  
The City

ABSTRACT Objective: to analyze the overall survival and prognostic factors of women with breast cancer in the city of Goiânia. Methods: this is a retrospective, cross-sectional, observational study that included women with malignant neoplasms of the breast identified by the Goiânia Population-based Cancer Registry. The variables studied were age at diagnosis, tumor size, staging, axillary lymph node involvement, tumor grade, disease extent, hormone receptors, and c-erb-B2 oncoprotein. We performed overall survival analyzes of five and ten years. Results: we included 2,273 patients in the study, with an overall survival of 72.1% in five years and 57.8% in ten years. In the multivariate analysis adjusted for tumor size, the factors that influenced the prognosis were axillary lymph nodes, histological grade, progesterone receptor, c erb B2, T staging and disease extension. Conclusion: overall survival in ten years is below that observed in other countries, and possibly reflects what happens with the majority of the Brazilian population. The prognostic factors found in this population follow the same international patterns.

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